About   Help   FAQ
Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Gcn1
GCN1 activator of EIF2AK4
MGI:2444248
37 phenotypes from 3 alleles in 3 genetic backgrounds
Export: Excel File
Allelic Composition
Genetic Background		 Annotated Term Reference
Gcn1em1(IMPC)J/Gcn1+
C57BL/6NJ-Gcn1em1(IMPC)J/Mmjax 		decreased circulating bilirubin level J:211773
increased circulating glucose level J:211773
Gcn1em1(IMPC)J/Gcn1em1(IMPC)J
C57BL/6NJ-Gcn1em1(IMPC)J/Mmjax 		abnormal chorioallantoic fusion J:374598
abnormal embryo morphology J:374598
abnormal embryo turning J:374598
abnormal head shape J:374598
abnormal heart morphology J:374598
abnormal placenta development J:374598
abnormal placenta labyrinth morphology J:374598
abnormal trophoblast layer morphology J:374598
abnormal vitelline vasculature morphology J:374598
decreased embryo size J:374598
embryonic growth retardation J:374598
embryonic lethality during organogenesis, complete penetrance J:374598
failure of chorioallantoic fusion J:374598
failure of initiation of embryo turning J:374598
incomplete embryo turning J:374598
incomplete rostral neuropore closure J:374598
preweaning lethality, complete penetrance J:211773
Gcn1em1Itohk/Gcn1em1Itohk
involves: C57BL/6 		decreased embryo size J:287528
embryonic growth retardation J:287528
embryonic lethality, complete penetrance J:287528
Gcn1em2Itohk/Gcn1em2Itohk
C57BL/6-Gcn1em2Itohk 		abnormal cell cycle checkpoint function J:287528
abnormal cell morphology J:287528
abnormal fibroblast physiology J:287528
abnormal head morphology J:287528
anencephaly J:287528
atelectasis J:287528
decreased embryo size J:287528
decreased fetal size J:287528
decreased fetal weight J:287528
decreased fibroblast proliferation J:287528
delayed limb development J:287528
embryonic growth retardation J:287528
exophthalmos J:287528
eyelid hypoplasia J:287528
fetal growth retardation J:287528
increased mitotic index J:287528
mandible hypoplasia J:287528
perinatal lethality, complete penetrance J:287528
respiratory failure J:287528
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory