Gcn1 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Gcn1
GCN1 activator of EIF2AK4
MGI:2444248

24 phenotypes from 3 alleles in 3 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Gcn1^em1(IMPC)J/Gcn1⁺ C57BL/6NJ-Gcn1^em1(IMPC)J/Mmjax	decreased circulating bilirubin level	J:211773
	increased circulating glucose level	J:211773
	increased leukocyte cell number	J:211773
Gcn1^em1(IMPC)J/Gcn1^em1(IMPC)J C57BL/6NJ-Gcn1^em1(IMPC)J/Mmjax	preweaning lethality, complete penetrance	J:211773
Gcn1^em1Itohk/Gcn1^em1Itohk involves: C57BL/6	decreased embryo size	J:287528
	embryonic growth retardation	J:287528
	embryonic lethality, complete penetrance	J:287528
Gcn1^em2Itohk/Gcn1^em2Itohk C57BL/6-Gcn1^em2Itohk	abnormal cell cycle checkpoint function	J:287528
	abnormal cell morphology	J:287528
	abnormal fibroblast physiology	J:287528
	abnormal head morphology	J:287528
	anencephaly	J:287528
	atelectasis	J:287528
	decreased embryo size	J:287528
	decreased fetal size	J:287528
	decreased fetal weight	J:287528
	decreased fibroblast proliferation	J:287528
	delayed limb development	J:287528
	embryonic growth retardation	J:287528
	exophthalmos	J:287528
	eyelid hypoplasia	J:287528
	fetal growth retardation	J:287528
	increased mitotic index	J:287528
	mandible hypoplasia	J:287528
	perinatal lethality, complete penetrance	J:287528
	respiratory failure	J:287528

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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