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Nr1d1 Gene Detail
Summary
  • Symbol
    Nr1d1
  • Name
    nuclear receptor subfamily 1, group D, member 1
  • Synonyms
    A530070C09Rik, rev-erbA(alpha), REV-ERBalpha
  • Feature Type
    protein coding gene
  • IDs
    MGI:2444210
    NCBI Gene: 217166
  • Gene Overview
    MyGene.info: NR1D1
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr11:98767932-98775333 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      7402 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 62.66 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    NR1D1, nuclear receptor subfamily 1 group D member 1
  • Vertebrate Orthologs
    8
  • Human Ortholog
    NR1D1, nuclear receptor subfamily 1 group D member 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    ear-1, EAR1, hRev, REVERBA, REVERBalpha, THRA1, THRAL
  • Links
    NCBI Gene ID: 9572
    neXtProt AC: NX_P20393
    UniProt: P20393

  • Chr Location
    17q21.1; chr17:40092784-40100725 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    40 phenotypes from 5 alleles in 7 genetic backgrounds
    7 phenotypes from multigenic genotypes
    49 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for targeted null mutations exhibit altered circadian behavior and temperature regulation with mild alterations in cytoarchitecture of the cerebellum. Litter size is reduced by half in mutant females.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000006407 VEGA Gene Model | MGI Sequence Detail 7402 C57BL/6J ±  kb
    transcript OTTMUST00000014594 VEGA | MGI Sequence Detail 2721 Not Applicable  
    polypeptide OTTMUSP00000006786 VEGA | MGI Sequence Detail 615 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      34 from dbSNP Build 142
    Protein
    Information
    less
    • UniProt
      1 Sequence
    • Protein Ontology
      PR:000011392 nuclear receptor subfamily 1 group D member 1
    • InterPro Domains
      IPR001723 Nuclear hormone receptor
      IPR000536 Nuclear hormone receptor, ligand-binding domain
      IPR035500 Nuclear hormone receptor-like domain superfamily
      IPR013088 Zinc finger, NHR/GATA-type
      IPR001628 Zinc finger, nuclear hormone receptor-type
    Molecular
    Reagents
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    • All nucleic 18
      cDNA 16
      Primer pair 2

      Microarray probesets 2
    Other
    Accession IDs
    less
    MGI:2144703
    References
    more
    • Summaries
      All 107
      Developmental Gene Expression 12
      Gene Ontology 16
      Phenotypes 49
    • Earliest
      J:23754 Forman BM, et al., Cross-talk among ROR alpha 1 and the Rev-erb family of orphan nuclear receptors. Mol Endocrinol. 1994 Sep;8(9):1253-61
    • Latest
      J:256095 Huang WC, et al., Diverse Non-genetic, Allele-Specific Expression Effects Shape Genetic Architecture at the Cellular Level in the Mammalian Brain. Neuron. 2017 Mar 8;93(5):1094-1109.e7

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    07/10/2018
    MGI 6.12
    The Jackson Laboratory