About   Help   FAQ
Nr1d1
Gene Detail
 Symbol
Name
ID
Nr1d1
nuclear receptor subfamily 1, group D, member 1
MGI:2444210
Synonyms A530070C09Rik, rev-erbA(alpha), REV-ERBalpha
Feature Type protein coding gene
Genetic Map
Chromosome 11
62.66 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr11:98767932-98775333 bp, - strand
From VEGA annotation of GRCm38

  7402 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:23324  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 western clawed frog; 1 zebrafish

Gene Tree: Nr1d1

Human
homologs
Human Homolog NR1D1, nuclear receptor subfamily 1, group D, member 1
NCBI Gene ID 9572
neXtProt AC  NX_P20393
Human Synonyms  ear-1, EAR1, hRev, THRA1, THRAL
Human Chr (Location)  17q11.2; chr17:40092784-40100725 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(12) : Gene trapped(4) Targeted(8)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes for targeted null mutations exhibit altered circadian behavior and mild alterations in cytoarchitecture of the cerebellum. Litter size is reduced by half in mutant females.
 
Interactions
Nr1d1 interacts with 135 markers (Mir7-1, Mir10b, Mir24-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (52 annotations)
Process cell differentiation, cellular response to lipopolysaccharide, ...
Component cell projection, cytoplasm, ...
Function core promoter sequence-specific DNA binding, DNA binding, ...
External Resources: FuncBase
Expression
Literature Summary: (9 records)
Data Summary: Results (124)    Tissues (101)    Images (13)
Theiler Stages: 2, 3, 4, 5, 17, 19, 20, 21, 22, 23, 24, 27, 28
Assay TypeResults
RNA in situ 116
RT-PCR 8
cDNA source data(14)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(16) cDNA(15) Primer pair(1)
Microarray probesets(2)
Other database
links
VEGA Gene ModelOTTMUSG00000006407 (Evidence)
Ensembl Gene ModelENSMUSG00000020889 (Evidence)
Entrez Gene217166 (Evidence)
NIA Mouse Gene IndexU033373
Consensus CDS ProjectCCDS25363.1
International Mouse Knockout Project StatusNr1d1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000006407 VEGA Gene Model | MGI Sequence Detail 7402 C57BL/6J ±  kb
transcript OTTMUST00000014594 VEGA | MGI Sequence Detail 2721 Not Applicable 
polypeptide OTTMUSP00000006786 VEGA | MGI Sequence Detail 615 Not Applicable 

For the selected sequences
All sequences(27) RefSeq(2) UniProt(1)
Polymorphisms SNPs within 2kb(34 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR008946 Nuclear hormone receptor, ligand-binding
InterPro IPR000536 Nuclear hormone receptor, ligand-binding, core
InterPro IPR001723 Steroid hormone receptor
InterPro IPR013088 Zinc finger, NHR/GATA-type
InterPro IPR001628 Zinc finger, nuclear hormone receptor-type
Protein Ontology PR:000011392 nuclear receptor subfamily 1 group D member 1
References (Earliest) J:23754 Forman BM, et al., Cross-talk among ROR alpha 1 and the Rev-erb family of orphan nuclear receptors. Mol Endocrinol. 1994 Sep;8(9):1253-61
(Latest) J:213068 Jager J, et al., Behavioral changes and dopaminergic dysregulation in mice lacking the nuclear receptor Rev-erbalpha. Mol Endocrinol. 2014 Apr;28(4):490-8
All references(72)
Other
accession IDs
MGI:2144703

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
09/23/2014
MGI 5.19
The Jackson Laboratory