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Dna2 Gene Detail
Summary
  • Symbol
    Dna2
  • Name
    DNA replication helicase/nuclease 2
  • Synonyms
    Dna2l, E130315B21Rik, mKIAA0083
  • Feature Type
    protein coding gene
  • IDs
    MGI:2443732
    NCBI Gene: 327762
  • Gene Overview
    MyGene.info: DNA2
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:62947026-62974185 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 10, 32.51 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    249 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2443732
protein coding gene Chr10:62946978-62974188 (.)
129S1/SvImJ MGP_129S1SvImJ_G0017308
protein coding gene Chr10:62431488-62461811 (+)
A/J MGP_AJ_G0017286
protein coding gene Chr10:60498668-60525666 (+)
AKR/J MGP_AKRJ_G0017246
protein coding gene Chr10:62086963-62120319 (+)
BALB/cJ MGP_BALBcJ_G0017246
protein coding gene Chr10:60607043-60634131 (+)
C3H/HeJ MGP_C3HHeJ_G0017069
protein coding gene Chr10:62008996-62037363 (+)
C57BL/6NJ MGP_C57BL6NJ_G0017704
protein coding gene Chr10:64669346-64699079 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0015394
protein coding gene Chr10:57442167-57467067 (+)
CAST/EiJ MGP_CASTEiJ_G0016640
protein coding gene Chr10:62059307-62088984 (+)
CBA/J MGP_CBAJ_G0017041
protein coding gene Chr10:67125388-67156927 (+)
DBA/2J MGP_DBA2J_G0017146
protein coding gene Chr10:59770777-59798384 (+)
FVB/NJ MGP_FVBNJ_G0017140
protein coding gene Chr10:59039438-59066985 (+)
LP/J MGP_LPJ_G0017220
protein coding gene Chr10:62801020-62831966 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0017168
protein coding gene Chr10:69292604-69323495 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0017742
protein coding gene Chr10:61931975-61961192 (+)
PWK/PhJ MGP_PWKPhJ_G0016423
protein coding gene Chr10:59649766-59678894 (+)
SPRET/EiJ MGP_SPRETEiJ_G0016205
protein coding gene Chr10:61283584-61313035 (+)
WSB/EiJ MGP_WSBEiJ_G0016704
protein coding gene Chr10:61881837-61913435 (+)



Homology
more
  • Human Ortholog
    DNA2, DNA replication helicase/nuclease 2
  • Vertebrate Orthologs
    10
  • Human Ortholog
    DNA2, DNA replication helicase/nuclease 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    DNA2L, hDNA2
  • Links
    NCBI Gene ID: 1763
    neXtProt AC: NX_P51530
    UniProt: P51530

  • Chr Location
    10q21.3; chr10:68414064-68472521 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 6124
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: DNA2
  • Gene Tree
Human Diseases
more
  • Diseases
    1 with human DNA2 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    10 phenotypes from 1 allele in 1 genetic background
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit embryonic lethality before E7.5. Mice heterozygous for the allele exhibit shortened telomeres, chromosome segregation errors and increased tumor incidence associated with aneuploidy.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000036875 Ensembl Gene Model | MGI Sequence Detail 27160 C57BL/6J ±  kb
transcript ENSMUST00000131422 Ensembl | MGI Sequence Detail 4122 Not Applicable  
polypeptide ENSMUSP00000115750 Ensembl | MGI Sequence Detail 1062 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 14
    cDNA 14

    Microarray probesets 3
References
more
  • Summaries
    All 35
    Gene Ontology 5
    Phenotypes 12
  • Earliest
    J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
  • Latest
    J:198831 Lin W, et al., Mammalian DNA2 helicase/nuclease cleaves G-quadruplex DNA and is required for telomere integrity. EMBO J. 2013 May 15;32(10):1425-39

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/13/2018
MGI 6.13
The Jackson Laboratory