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Dna2 Gene Detail
Summary
  • Symbol
    Dna2
  • Name
    DNA replication helicase/nuclease 2
  • Synonyms
    Dna2l, E130315B21Rik, mKIAA0083
  • Feature Type
    protein coding gene
  • IDs
    MGI:2443732
    NCBI Gene: 327762
  • Gene Overview
    MyGene.info: DNA2
Location & Maps
more
  • Sequence Map
    Chr10:62947026-62974185 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      27160 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 10, 32.51 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    DNA2, DNA replication helicase/nuclease 2
  • Vertebrate Orthologs
    10
  • Human Ortholog
    DNA2, DNA replication helicase/nuclease 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    DNA2L, hDNA2
  • Links
    NCBI Gene ID: 1763
    neXtProt AC: NX_P51530

  • Chr Location
    10q21.3-q22.1; chr10:68414064-68472516 (-)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 6124
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed
  • HCOP
    human homology predictions: DNA2
  • Gene Tree
Human Diseases
more
  • Diseases
    2 with human DNA2 associations

Human Disease Mouse Models
       Progressive External Ophthalmoplegia with Mitochondrial DNA Deletions, Autosomal Dominant 6; PEOA6   OMIM: 615156
Seckel Syndrome 8; SCKL8   OMIM: 615807
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    10 phenotypes from 1 allele in 1 genetic background
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    16
  • Chemically induced (other)
    1
  • Gene trapped
    11
  • Radiation induced
    1
  • Targeted
    3
  • Genomic Mutations
    2 involving Dna2
  • Incidental Mutations
Mice homozygous for a knock-out allele exhibit embryonic lethality before E7.5. Mice heterozygous for the allele exhibit shortened telomeres, chromosome segregation errors and increased tumor incidence associated with aneuploidy.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000030825 VEGA Gene Model | MGI Sequence Detail 27160 C57BL/6J ±  kb
transcript OTTMUST00000076285 VEGA | MGI Sequence Detail 4122 Not Applicable  
polypeptide OTTMUSP00000040133 VEGA | MGI Sequence Detail 1062 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    249 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 12
    cDNA 12

    Microarray probesets 3
References
more
  • Summaries
    All 28
    Gene Ontology 4
    Phenotypes 12
  • Earliest
    J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
  • Latest
    J:198831 Lin W, et al., Mammalian DNA2 helicase/nuclease cleaves G-quadruplex DNA and is required for telomere integrity. EMBO J. 2013 May 15;32(10):1425-39

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/27/2016
MGI 6.05
The Jackson Laboratory