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Dna2
Gene Detail
Symbol

Name
ID
Dna2
DNA replication helicase 2 homolog (yeast)
MGI:2443732
Synonyms
Dna2l, E130315B21Rik, mKIAA0083
Feature Type
protein coding gene
Genetic Map
Chromosome 10
32.51 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr10:62947026-62974185 bp, + strand
From VEGA annotation of GRCm38

  27160 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:6124  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Dna2

Human
homologs
Human Homolog DNA2, DNA replication helicase/nuclease 2
NCBI Gene ID 1763
neXtProt AC  NX_P51530
Human Synonyms  DNA2L, hDNA2
Human Chr (Location)  10q21.3-q22.1; chr10:68414064-68472409 (-)  GRCh38
Disease Associations  (2) Diseases Associated with Human DNA2
Mutations,
alleles, and
phenotypes
All mutations/alleles(14) : Gene trapped(11) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele exhibit embryonic lethality before E7.5. Mice heterozygous for the allele exhibit shortened telomeres, chromosome segregation errors and increased tumor incidence associated with aneuploidy.
 
Interactions
Dna2 interacts with 150 markers (Mir1b, Mir19a, Mir20a, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (38 annotations)
Process ATP catabolic process, base-excision repair, ...
Component gamma DNA polymerase complex, mitochondrial nucleoid, ...
Function 4 iron, 4 sulfur cluster binding, 5'-3' DNA helicase activity, ...
External Resources: FuncBase
Expression
cDNA source data(12)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(12) cDNA(12)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000030825 (Evidence)
Ensembl Gene ModelENSMUSG00000036875 (Evidence)
Entrez Gene327762 (Evidence)
DFCITC1709261, TC1610069, TC1577578, TC1608698
DoTSDT.101382169, DT.91406393, DT.101714724
NIA Mouse Gene IndexU011588
EC3.1.-.-, 3.6.4.12
Consensus CDS ProjectCCDS35923.1
International Mouse Knockout Project StatusDna2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000030825 VEGA Gene Model | MGI Sequence Detail 27160 C57BL/6J ±  kb
transcript OTTMUST00000076285 VEGA | MGI Sequence Detail 4122 Not Applicable 
polypeptide OTTMUSP00000040133 VEGA | MGI Sequence Detail 1062 Not Applicable 

For the selected sequences
All sequences(50) RefSeq(4) UniProt(3)
Polymorphisms
SNPs within 2kb(250 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR014808 DNA replication factor Dna2, N-terminal
InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
Protein Ontology PR:000006554 DNA replication ATP-dependent helicase/nuclease DNA2
References
(Earliest) J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
(Latest) J:198831 Lin W, et al., Mammalian DNA2 helicase/nuclease cleaves G-quadruplex DNA and is required for telomere integrity. EMBO J. 2013 May 15;32(10):1425-39
All references(32)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/09/2014
MGI 5.20
The Jackson Laboratory