Lefty2
Gene Detail

Symbol Name ID

Lefty2 left-right determination factor 2 MGI:2443573

Synonyms

6030463A22Rik, Ebaf, Leftb

Feature Type

protein coding gene

Genetic Map

Chromosome 1

84.46 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr1:180893108-180899103 bp, + strand From VEGA annotation of GRCm38   5996 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:2434  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 2 cattle; 1 dog

Protein SuperFamily: lefty protein
Gene Tree: Lefty2

Human homologs

Human Homolog		LEFTY2, left-right determination factor 2
NCBI Gene ID		7044
neXtProt AC		NX_O00292
Human Synonyms		EBAF, LEFTA, LEFTYA, TGFB4
Human Chr (Location)		1q42.1; chr1:226124298-226129083 (-)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human LEFTY2

Alleles and phenotypes

All alleles(16) : Targeted(2) Gene trapped(14)
 

Mice homozygous for one null allele exhibit embryonic lethality, defects in axial patterning, absent notochord, somites, head folds and heart, and defects yolk sac development. Mice homozygous for another allele exhibit postnatal lethality and left isomerism.

 

Gene Ontology (GO) classifications

All GO classifications: (9 annotations)

Process	cell growth, growth, ...
Component	extracellular region, extracellular space
Function	cytokine activity, growth factor activity, ...

External Resources: FuncBase

Expression

Literature Summary: (106 records)
Data Summary: Results (152)    Tissues (27)    Images (52)
Theiler Stages: 2, 3, 4, 5, 9, 10, 11, 12, 13

Assay Type	Results
RNA in situ	114
RT-PCR	38

cDNA source data(21)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(42) Genomic(5) cDNA(26) Primer pair(2) Other(9)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000021474 (Evidence)
Ensembl Gene Model	ENSMUSG00000066652 (Evidence)
Entrez Gene	320202 (Evidence)
UniGene	87078
DFCI	TC1586882, TC1608759
DoTS	DT.55126805, DT.91558190, DT.97385821
NIA Mouse Gene Index	U001201, U022146
Consensus CDS Project	CCDS15575.1
International Mouse Knockout Project Status	Lefty2

Sequences

Length	Strain/Species
genomic	OTTMUSG00000021474	VEGA Gene Model | MGI Sequence Detail	5996	C57BL/6J
transcript	OTTMUST00000050909	VEGA | MGI Sequence Detail	2473	Not Applicable
polypeptide	OTTMUSP00000023877	VEGA | MGI Sequence Detail	368	Not Applicable

All sequences(25) RefSeq(2) UniProt(1)

Polymorphisms

SNPs(76 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR003942	Left- Right determination factor
InterPro	IPR017948	Transforming growth factor beta, conserved site
InterPro	IPR001839	Transforming growth factor-beta, C-terminal
InterPro	IPR001111	Transforming growth factor-beta, N-terminal
InterPro	IPR015615	Transforming growth factor-beta-related
Protein Ontology	PR:000000288	lefty 2

References

(Earliest) J:49270 Meno C, et al., Two closely-related left-right asymmetrically expressed genes, lefty-1 and lefty-2: their distinct expression domains, chromosomal linkage and direct neuralizing activity in Xenopus embryos. Genes Cells. 1997 Aug;2(8):513-24
(Latest) J:191052 Wu Q, et al., Nodal/activin signaling promotes male germ cell fate and suppresses female programming in somatic cells. Development. 2013 Jan;140(2):291-300
All references(136)

Other accession IDs

MGI:2138525