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Lefty2
Gene Detail
Symbol

Name
ID
Lefty2
left-right determination factor 2
MGI:2443573
Synonyms
6030463A22Rik, Ebaf, Leftb
Feature Type
protein coding gene
Genetic Map
Chromosome 1
84.46 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr1:180893108-180899103 bp, + strand
From VEGA annotation of GRCm38

  5996 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:2434  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 2 cattle; 1 dog

HCOP human homology predictions: LEFTY2
Protein SuperFamily: lefty protein
Gene Tree: Lefty2

Human
homologs
LEFTY2, left-right determination factor 2
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 7044
neXtProt AC: NX_O00292

Human Synonyms: EBAF, LEFTA, LEFTYA, TGFB4

Human Chr (Location): 1q42.1; chr1:225936598-225941383 (-)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human LEFTY2

Mutations,
alleles, and
phenotypes
All mutations/alleles(16) : Gene trapped(14) Targeted(2)
 
Mice homozygous for one null allele exhibit embryonic lethality, defects in axial patterning, absent notochord, somites, head folds and heart, and defects yolk sac development. Mice homozygous for another allele exhibit postnatal lethality and left isomerism.
 
Interactions
Lefty2 interacts with 150 markers (Mir10a, Mir15b, Mir19a, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (15 annotations)
Process cell development, cell growth, ...
Component extracellular matrix, extracellular region, ...
Function cytokine activity, growth factor activity, ...
External Resources: FuncBase
Expression
Literature Summary: (113 records)
Data Summary: Results (180)    Tissues (27)    Images (65)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 142
RT-PCR 38
cDNA source data(21)
Other mouse links: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(44) Genomic(5) cDNA(26) Primer pair(2) Other(11)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000021474 (Evidence)
Ensembl Gene Model ENSMUSG00000066652 (Evidence)
Entrez Gene 320202 (Evidence)
UniGene 87078
DFCI TC1608759, TC1586882
DoTS DT.91558190, DT.97385821, DT.55126805
NIA Mouse Gene Index U001201, U022146
Consensus CDS Project CCDS15575.1
International Mouse Phenotyping Consortium Status Lefty2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000021474 VEGA Gene Model | MGI Sequence Detail 5996 C57BL/6J ±  kb
transcript OTTMUST00000050909 VEGA | MGI Sequence Detail 2473 Not Applicable 
polypeptide OTTMUSP00000023877 VEGA | MGI Sequence Detail 368 Not Applicable 

For the selected sequences
All sequences(25) RefSeq(2) UniProt(1)
Polymorphisms
SNPs within 2kb(139 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR003942 Left- Right determination factor
InterPro IPR017948 Transforming growth factor beta, conserved site
InterPro IPR001839 Transforming growth factor-beta, C-terminal
InterPro IPR001111 Transforming growth factor-beta, N-terminal
InterPro IPR015615 Transforming growth factor-beta-related
Protein Ontology PR:000000288 lefty 2
References
(Earliest) J:49270 Meno C, et al., Two closely-related left-right asymmetrically expressed genes, lefty-1 and lefty-2: their distinct expression domains, chromosomal linkage and direct neuralizing activity in Xenopus embryos. Genes Cells. 1997 Aug;2(8):513-24
(Latest) J:219394 Boroviak T, et al., The ability of inner-cell-mass cells to self-renew as embryonic stem cells is acquired following epiblast specification. Nat Cell Biol. 2014 Jun;16(6):516-28
All references(143)
Other
accession IDs
MGI:2138525

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/28/2015
MGI 5.22
The Jackson Laboratory