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Lefty2 Gene Detail
Summary
  • Symbol
    Lefty2
  • Name
    left-right determination factor 2
  • Synonyms
    6030463A22Rik, Ebaf, Leftb
  • Feature Type
    protein coding gene
  • IDs
    MGI:2443573
    NCBI Gene: 320202
Location & Maps
more
  • Sequence Map
    Chr1:180893108-180899103 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      5996 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 1, 84.46 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    LEFTY2, left-right determination factor 2
  • Vertebrate Orthologs
    8
  • Human Ortholog
    LEFTY2, left-right determination factor 2
    Orthology source: HGNC, HomoloGene
  • Synonyms
    EBAF, LEFTA, LEFTYA, TGFB4
  • Links
    NCBI Gene ID: 7044
    neXtProt AC: NX_O00292

  • Chr Location
    1q42.1; chr1:225936598-225941383 (-)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with human LEFTY2 associations

Human Disease Mouse Models
       Left-Right Determination Factor 2; LEFTY2   OMIM: 601877
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    31 phenotypes from 2 alleles in 2 genetic backgrounds
    3 phenotypes from multigenic genotypes
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    18
  • Chemically induced (other)
    2
  • Gene trapped
    14
  • Targeted
    2
  • Genomic Mutations
    2 involving Lefty2
Mice homozygous for one null allele exhibit embryonic lethality, defects in axial patterning, absent notochord, somites, head folds and heart, and defects yolk sac development. Mice homozygous for another allele exhibit postnatal lethality and left isomerism.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000021474 VEGA Gene Model | MGI Sequence Detail 5996 C57BL/6J ±  kb
transcript OTTMUST00000050909 VEGA | MGI Sequence Detail 2473 Not Applicable  
polypeptide OTTMUSP00000023877 VEGA | MGI Sequence Detail 368 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    139 from dbSNP Build 142
Protein
Information
less
  • UniProt
    1 Sequence
  • InterPro Domains
    IPR029034 Cystine-knot cytokine
    IPR003942 Left- Right determination factor
    IPR017948 Transforming growth factor beta, conserved site
    IPR001839 Transforming growth factor-beta, C-terminal
    IPR001111 Transforming growth factor-beta, N-terminal
    IPR015615 Transforming growth factor-beta-related
Molecular
Reagents
less
  • All nucleic 44
    Genomic 5
    cDNA 26
    Primer pair 2
    Other 11

    Microarray probesets 3
Other
Accession IDs
less
MGI:2138525
References
more
  • Summaries
    All 140
    Developmental Gene Expression 114
    Gene Ontology 4
    Phenotypes 10
  • Earliest
    J:49270 Meno C, et al., Two closely-related left-right asymmetrically expressed genes, lefty-1 and lefty-2: their distinct expression domains, chromosomal linkage and direct neuralizing activity in Xenopus embryos. Genes Cells. 1997 Aug;2(8):513-24
  • Latest
    J:219394 Boroviak T, et al., The ability of inner-cell-mass cells to self-renew as embryonic stem cells is acquired following epiblast specification. Nat Cell Biol. 2014 Jun;16(6):516-28

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/15/2016
MGI 6.04
The Jackson Laboratory