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Themis Gene Detail
Summary
  • Symbol
    Themis
  • Name
    thymocyte selection associated
  • Synonyms
    E430004N04Rik, Gasp, Tsepa
  • Feature Type
    protein coding gene
  • IDs
    MGI:2443552
    NCBI Gene: 210757
  • Alliance
    genome feature page
  • Transcription Start Sites
    33 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:28544356-28759814 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 10, 16.06 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    6618 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2443552
 protein coding gene Chr10:28544356-28759816 (+)
129S1/SvImJ ENSMUSG00200009311
 protein coding gene Chr10:25385294-25600752 (+)
A/J ENSMUSG00195013662
 protein coding gene Chr10:25668940-25884413 (+)
AKR/J ENSMUSG00220010874
 protein coding gene Chr10:25342038-25566957 (+)
BALB/cJ ENSMUSG00180016463
 protein coding gene Chr10:25794059-26009529 (+)
C3H/HeJ ENSMUSG00175025064
 protein coding gene Chr10:25505368-25728375 (+)
C57BL/6NJ ENSMUSG00215008157
 protein coding gene Chr10:25342241-25557712 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0015203
 protein coding gene Chr10:24529601-24742604 (+)
CAST/EiJ ENSTCUG00005013793
 protein coding gene Chr10:25158961-25375625 (+)
CBA/J ENSMUSG00210023253
 protein coding gene Chr10:25433284-25656285 (+)
DBA/2J ENSMUSG00185007040
 protein coding gene Chr10:25605430-25828433 (+)
FVB/NJ ENSMUSG00205009856
 protein coding gene Chr10:25607878-25831580 (+)
JF1/MsJ ENSUMUG00000012807
 protein coding gene Chr10:25423599-25637124 (+)
LP/J ENSMUSG00230009276
 protein coding gene Chr10:27397582-27613031 (+)
NOD/ShiLtJ ENSMUSG00190014721
 protein coding gene Chr10:25734689-25950135 (+)
NZO/HlLtJ ENSMUSG00225033041
 protein coding gene Chr10:31656457-31871934 (+)
PWK/PhJ ENSLUMG00010009756
 protein coding gene Chr10:25286369-25507704 (+)
SPRET/EiJ ENSMSPG00010014003
 protein coding gene Chr10:26126115-26362008 (+)
WSB/EiJ ENSIUOG00005030430
 protein coding gene Chr10:25061413-25290970 (+)



Homology
more
  • Human Ortholog
    THEMIS, thymocyte selection associated
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    THEMIS, thymocyte selection associated
  • Synonyms
    C6orf190, C6orf207, GASP, SPOT, THEMIS1, TSEPA
  • Links
    NCBI Gene ID: 387357
    UniProt: Q8N1K5

  • Chr Location
    6q22.33; chr6:127696628-127918631 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    38 phenotypes from 11 alleles in 11 genetic backgrounds
    9 phenotypes from multigenic genotypes
    44 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice have defects in T cell positive selection that leads to very few alpha-beta T cells being found in the periphery.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    22
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    606
  • Tissues
    9
  • cDNA Data
    31
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000049109 Ensembl Gene Model | MGI Sequence Detail 215459 C57BL/6J ±  kb
    transcript ENSMUST00000056097 Ensembl | MGI Sequence Detail 5082 Not Applicable  
    polypeptide ENSMUSP00000060129 Ensembl | MGI Sequence Detail 636 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 31
      cDNA 31

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:2143898
    References
    more
    • Summaries
      All 69
      Developmental Gene Expression 1
      Gene Ontology 10
      Phenotypes 44
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:387089 Qiu X, et al., THEMIS attenuates MASH by suppressing disease-associated hepatocyte induction and hepatocyte senescence in mice. J Clin Invest. 2026 May 1;136(9)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory