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Themis
Gene Detail
Symbol

Name
ID
Themis
thymocyte selection associated
MGI:2443552
Synonyms
E430004N04Rik, Gasp, Tsepa
Feature Type
protein coding gene
Genetic Map
Chromosome 10
16.06 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr10:28668360-28883818 bp, + strand
From VEGA annotation of GRCm38

  215459 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:72287  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Themis

Human
homologs
Human Homolog THEMIS, thymocyte selection associated
NCBI Gene ID 387357
neXtProt AC  NX_Q8N1K5
Human Synonyms  bA325O24.3, bA325O24.4, C6orf190, C6orf207, GASP, SPOT, TSEPA
Human Chr (Location)  6q22.33; chr6:127708194-127918631 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(11) : Chemically induced (ENU)(3) Gene trapped(2) Targeted(6)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null mice have defects in T cell positive selection that leads to very few alpha-beta T cells being found in the periphery.
 
Interactions
Themis interacts with 370 markers (Mir1a-1, Mir1a-2, Mir7-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (12 annotations)
Process immune system process, multicellular organismal development, ...
Component cell-cell junction, COP9 signalosome, ...
Function protein binding
External Resources: FuncBase
Expression
Literature Summary: (1 records)
Data Summary: Results (9)    Tissues (9)    Images (1)    Tissue x Stage Matrix (view)
Assay TypeResults
Northern blot 9
cDNA source data(30)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(30) cDNA(30)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000034168 (Evidence)
Ensembl Gene ModelENSMUSG00000049109 (Evidence)
Entrez Gene210757 (Evidence)
UniGene123021
DFCITC1583774, TC1593091, TC1596190
DoTSDT.99847972, DT.91337255, DT.91316196, DT.91298960, DT.489134, DT.110586318
NIA Mouse Gene IndexU011370
Consensus CDS ProjectCCDS23758.1
International Mouse Knockout Project StatusThemis
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000034168 VEGA Gene Model | MGI Sequence Detail 215459 C57BL/6J ±  kb
transcript OTTMUST00000086621 VEGA | MGI Sequence Detail 5082 Not Applicable 
polypeptide OTTMUSP00000046903 VEGA | MGI Sequence Detail 636 Not Applicable 

For the selected sequences
All sequences(64) RefSeq(6) UniProt(5)
Polymorphisms
SNPs within 2kb(1484 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR025946 CABIT domain
Protein Ontology PR:000031234 protein THEMIS
References
(Earliest) J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
(Latest) J:213434 Okada T, et al., Differential function of Themis CABIT domains during T cell development. PLoS One. 2014;9(2):e89115
All references(38)
Other
accession IDs
MGI:2143898

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/18/2014
MGI 5.20
The Jackson Laboratory