Themis Phenotype Annotations - Multigenic Genotypes

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Themis
thymocyte selection associated
MGI:2443552

9 phenotypes from multigenic genotypes

Allelic Composition Genetic Background	Annotated Term	Reference
B2m^tm1Jae/B2m^tm1Jae Themis^tm1Lov/Themis^tm1Lov involves: 129	abnormal CD8-positive, alpha-beta T cell differentiation	J:151075
H2-Ab1^b-tm1Gru/H2-Ab1^b-tm1Gru Themis^tm1Lov/Themis^tm1Lov involves: 129	abnormal negative T cell selection	J:151075
H2^b/H2^d Themis^tm1Gasc/Themis^tm1Gasc involves: 129S6/SvEvTac * C57BL/6 * C57BL/10 * DBA/2	abnormal negative T cell selection	J:151074
Rag2^tm1Fwa/Rag2^tm1Fwa Tg(Tcra5CC7,Tcrb5CC7)IWep/? Themis^5AT161/Themis^5AT161 involves: 129S/SvEv * C57BL/6	arrested T cell differentiation	J:151076
	increased double-positive T cell number	J:151076
Rag2^tm1Fwa/Rag2^tm1Fwa Tg(TcraH-Y,TcrbH-Y)71Vbo/? Themis^5AT161/Themis^5AT161 involves: 129S/SvEv * C57BL/6 * DBA/2	decreased single-positive T cell number	J:151076
Tg(CD2-Zbtb7b)C8Rbo/? Themis^tm1Lov/Themis^tm1Lov involves: 129	abnormal T cell differentiation	J:151075
Tg(TcraH-Y,TcrbH-Y)71Vbo/? Themis^tm1Gasc/Themis^tm1Gasc involves: 129S6/SvEvTac * C57BL/6 * DBA/2	abnormal negative T cell selection	J:151074
	abnormal positive T cell selection	J:151074
Tg(TcraH-Y,TcrbH-Y)71Vbo/? Themis^tm1Lov/Themis^tm1Lov involves: 129 * C57BL/6 * DBA/2	abnormal negative T cell selection	J:151075
	abnormal positive T cell selection	J:151075
	decreased single-positive T cell number	J:151075
	increased double-positive T cell number	J:151075
Tg(TcrAND)53Hed/? Themis^tm1Gasc/Themis^tm1Gasc involves: 129S6/SvEvTac * C57BL/6 * SJL	abnormal positive T cell selection	J:151074
	decreased CD4-positive, alpha-beta T cell number	J:151074
	decreased CD8-positive, alpha-beta T cell number	J:151074
	increased double-positive T cell number	J:151074
Tg(TcrAND)53Hed/? Themis^tm1Lov/Themis^tm1Lov involves: 129 * C57BL/6 * SJL	abnormal positive T cell selection	J:151075
	decreased single-positive T cell number	J:151075
	increased double-positive T cell number	J:151075
Tg(TcraTcrb)1100Mjb/? Themis^tm1Gasc/Themis^tm1Gasc involves: 129S6/SvEvTac * C57BL/6	abnormal positive T cell selection	J:151074
	decreased CD8-positive, alpha-beta T cell number	J:151074
	increased double-positive T cell number	J:151074

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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