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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Themis
thymocyte selection associated
MGI:2443552
38 phenotypes from 11 alleles in 11 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Themis5AT161/Themis5AT161
involves: C57BL/6 		decreased CD4-positive, alpha-beta T cell number J:151076
decreased CD8-positive, alpha-beta T cell number J:151076
decreased regulatory T cell number J:151076
decreased single-positive T cell number J:151076
Themism1Btlr/Themism1Btlr
C57BL/6J-Themism1Btlr 		abnormal lymphocyte morphology J:211400
decreased B-1a cell number J:211400
decreased CD4-positive, alpha-beta T cell number J:211400
decreased CD8-positive, alpha-beta T cell number J:211400
normal immune system phenotype J:211400
impaired humoral immune response J:211400
Themism2Btlr/Themism2Btlr
C57BL/6J-Themism2Btlr 		decreased CD4-positive, alpha-beta T cell number J:236691
decreased T cell number J:236691
impaired hematopoiesis J:236691
increased CD8-positive, alpha-beta T cell number J:236691
increased effector memory CD4-positive, alpha-beta T cell number J:236691
Themism3Btlr/Themism3Btlr
C57BL/6J-Themism3Btlr 		abnormal CD8-positive, alpha-beta cytotoxic T cell morphology J:254834
decreased CD4-positive, CD25-positive, alpha-beta regulatory T cell number J:254834
decreased CD8-positive, alpha-beta memory T cell number J:254834
decreased CD8-positive, naive alpha-beta T cell number J:254834
increased CD4-positive, CD25-positive, alpha-beta regulatory T cell number J:254834
increased CD8-positive, alpha-beta memory T cell number J:254834
increased central memory CD4-positive, alpha-beta T cell number J:254834
increased central memory CD8 positive, alpha-beta T cell number J:254834
increased effector memory CD4-positive, alpha-beta T cell number J:254834
ThemisM4Btlr/ThemisM4Btlr
C57BL/6J-ThemisM4Btlr 		decreased CD4-positive, alpha-beta T cell number J:272849
Themism5Btlr/Themism5Btlr
C57BL/6J-Themism5Btlr 		abnormal CD4-positive T cell differentiation J:274716
abnormal CD8-positive, alpha-beta T cell differentiation J:274716
abnormal T cell differentiation J:274716
decreased alpha-beta T cell number J:274716
decreased CD4-positive, alpha-beta T cell number J:274716
decreased CD8-positive, alpha-beta T cell number J:274716
decreased CD8-positive, naive alpha-beta T cell number J:274716
increased CD8-positive, alpha-beta memory T cell number J:274716
increased central memory CD4-positive, alpha-beta T cell number J:274716
increased central memory CD8 positive, alpha-beta T cell number J:274716
increased effector memory CD4-positive, alpha-beta T cell number J:274716
increased effector memory CD8-positive, alpha-beta T cell number J:274716
increased NK T cell number J:274716
ThemisSpotr/Themis+
C57BL/6-ThemisSpotr 		decreased CD4-positive, alpha-beta T cell number J:152601
decreased CD8-positive, alpha-beta T cell number J:152601
ThemisSpotr/ThemisSpotr
C57BL/6-ThemisSpotr 		abnormal T cell differentiation J:152601
decreased CD4-positive, alpha-beta T cell number J:152601
decreased CD8-positive, alpha-beta T cell number J:152601
small thymus medulla J:152601
Themistm1.1Hko/Themis+
Not Specified 		decreased CD4-positive, alpha-beta T cell number J:152601
decreased CD8-positive, alpha-beta T cell number J:152601
Themistm1.1Hko/Themistm1.1Hko
Not Specified 		decreased CD4-positive, alpha-beta T cell number J:152601
decreased CD8-positive, alpha-beta T cell number J:152601
decreased single-positive T cell number J:152601
Themistm1Gasc/Themistm1Gasc
B6.129S-Themistm1Gasc 		abnormal memory T cell morphology J:151074
abnormal positive T cell selection J:151074
abnormal regulatory T cell morphology J:151074
abnormal thymus medulla morphology J:151074
decreased CD4-positive, alpha-beta T cell number J:151074
decreased CD8-positive, alpha-beta T cell number J:151074
decreased T cell proliferation J:151074
decreased thymocyte number J:151074
increased double-positive T cell number J:151074
Themistm1Hasu/Themis+
involves: C57BL/6 * CBA 		decreased CD4-positive, alpha-beta T cell number J:153235
decreased CD8-positive, alpha-beta T cell number J:153235
Themistm1Hasu/Themistm1Hasu
involves: C57BL/6 * CBA 		abnormal T cell differentiation J:153235
decreased CD4-positive, alpha-beta T cell number J:153235
decreased CD8-positive, alpha-beta T cell number J:153235
decreased splenocyte number J:153235
decreased thymocyte number J:153235
increased memory T cell number J:153235
increased T cell proliferation J:153235
Themistm1Lov/Themistm1Lov
involves: 129 		abnormal negative T cell selection J:151075
abnormal T cell differentiation J:151075
decreased CD4-positive, alpha-beta T cell number J:151075
decreased CD8-positive, alpha-beta T cell number J:151075
decreased regulatory T cell number J:151075
decreased single-positive T cell number J:151075
increased memory T cell number J:151075
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/30/2024
MGI 6.23 		The Jackson Laboratory