About   Help   FAQ
Map3k20 Gene Detail
Summary
  • Symbol
    Map3k20
  • Name
    mitogen-activated protein kinase kinase kinase 20
  • Synonyms
    B230120H23Rik, MLTKalpha, MLTKbeta, Zak
  • Feature Type
    protein coding gene
  • IDs
    MGI:2443258
    NCBI Gene: 65964
  • Gene Overview
    MyGene.info: MAP3K20
Location & Maps
more
  • Sequence Map
    Chr2:72285637-72442610 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      156974 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 2, 43.11 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    MAP3K20, mitogen-activated protein kinase kinase kinase 20
  • Vertebrate Orthologs
    10
  • Human Ortholog
    MAP3K20, mitogen-activated protein kinase kinase kinase 20
    Orthology source: HomoloGene, HGNC
  • Synonyms
    AZK, MLK7, mlklak, MLT, MLTK, MLTKalpha, MLTKbeta, MRK, pk, SFMMP, ZAK
  • Links
    NCBI Gene ID: 51776
    neXtProt AC: NX_Q9NYL2
    UniProt: Q9NYL2

  • Chr Location
    2q31.1; chr2:173075435-173268009 (+)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with Map3k20 mouse models

Human Disease Mouse Models
      
IDs
View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    8 phenotypes from 2 alleles in 1 genetic background
    18 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit complete lethality at E9.5 with growth retardation. Mice homozygous for an allele lacking the SAM domain exhibit low penetrant unilateral complex hindlimb duplication phenotype.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000013165 VEGA Gene Model | MGI Sequence Detail 156974 C57BL/6J ±  kb
transcript OTTMUST00000031795 VEGA | MGI Sequence Detail 3334 Not Applicable  
polypeptide OTTMUSP00000014168 VEGA | MGI Sequence Detail 802 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    1194 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 16
    cDNA 10
    Primer pair 5
    Other 1

    Microarray probesets 7
Other
Accession IDs
less
MGI:1931274, MGI:2139236
References
more
  • Summaries
    All 42
    Developmental Gene Expression 3
    Diseases 1
    Gene Ontology 6
    Phenotypes 18
  • Earliest
    J:67266 Gotoh I, et al., Identification and characterization of a novel MAP kinase kinase kinase, MLTK. J Biol Chem. 2001 Feb 9;276(6):4276-86
  • Latest
    J:231885 Beccari L, et al., A role for HOX13 proteins in the regulatory switch between TADs at the HoxD locus. Genes Dev. 2016 May 15;30(10):1172-86

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
09/12/2017
MGI 6.10
The Jackson Laboratory