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Zak Gene Detail
Summary
  • Symbol
    Zak
  • Name
    sterile alpha motif and leucine zipper containing kinase AZK
  • Synonyms
    B230120H23Rik, MLTKalpha, MLTKbeta
  • Feature Type
    protein coding gene
  • IDs
    MGI:2443258
    NCBI Gene: 65964
  • Gene Overview
    MyGene.info: ZAK
Location & Maps
more
  • Sequence Map
    Chr2:72285637-72442610 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      156974 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 2, 43.11 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    ZAK, sterile alpha motif and leucine zipper containing kinase AZK
  • Vertebrate Orthologs
    10
  • Human Ortholog
    ZAK, sterile alpha motif and leucine zipper containing kinase AZK
    Orthology source: HomoloGene
  • Synonyms
    AZK, MLK7, mlklak, MLT, MLTK, MRK, pk, SFMMP
  • Links
    NCBI Gene ID: 51776
    neXtProt AC: NX_Q9NYL2

  • Chr Location
    2q24.2; chr2:173075837-173268009 (+)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 32331
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 western clawed frog;1 zebrafish
  • HCOP
    human homology predictions: ZAK
  • Gene Tree
    Zak
Human Diseases
more
  • Diseases
    1 with human ZAK associations

Human Disease Mouse Models
       Split-Foot Malformation with Mesoaxial Polydactyly; SFMMP   OMIM: 616890
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    16 phenotype references
  • All Mutations and Alleles
    14
  • Chemically induced (other)
    1
  • Gene trapped
    4
  • Targeted
    9
  • Genomic Mutations
    7 involving Zak
  • Incidental Mutations
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000013165 VEGA Gene Model | MGI Sequence Detail 156974 C57BL/6J ±  kb
transcript OTTMUST00000031795 VEGA | MGI Sequence Detail 3334 Not Applicable  
polypeptide OTTMUSP00000014168 VEGA | MGI Sequence Detail 802 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    1194 from dbSNP Build 142
Protein
Information
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  • UniProt
    4 Sequences
  • Protein Ontology
    PR:000010457 mitogen-activated protein kinase kinase kinase MLT
  • EC
  • InterPro Domains
    IPR032938 Mitogen-activated protein kinase kinase kinase MLT
    IPR000719 Protein kinase domain
    IPR011009 Protein kinase-like domain
    IPR008271 Serine/threonine-protein kinase, active site
    IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
    IPR001660 Sterile alpha motif domain
    IPR013761 Sterile alpha motif/pointed domain
Molecular
Reagents
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  • All nucleic 10
    cDNA 10

    Microarray probesets 7
Other
Accession IDs
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MGI:1931274, MGI:2139236
References
more
  • Summaries
    All 28
    Developmental Gene Expression 3
    Gene Ontology 5
    Phenotypes 16
  • Earliest
    J:67266 Gotoh I, et al., Identification and characterization of a novel MAP kinase kinase kinase, MLTK. J Biol Chem. 2001 Feb 9;276(6):4276-86
  • Latest
    J:231477 Spielmann M, et al., Exome sequencing and CRISPR/Cas genome editing identify mutations of ZAK as a cause of limb defects in humans and mice. Genome Res. 2016 Feb;26(2):183-91

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/17/2016
MGI 6.05
The Jackson Laboratory