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Map3k20 Gene Detail
Summary
  • Symbol
    Map3k20
  • Name
    mitogen-activated protein kinase kinase kinase 20
  • Synonyms
    B230120H23Rik, MLTKalpha, MLTKbeta, Zak
  • Feature Type
    protein coding gene
  • IDs
    MGI:2443258
    NCBI Gene: 65964
  • Gene Overview
    MyGene.info: MAP3K20
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr2:72285637-72442610 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      156974 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 2, 43.11 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    MAP3K20, mitogen-activated protein kinase kinase kinase 20
  • Vertebrate Orthologs
    10
  • Human Ortholog
    MAP3K20, mitogen-activated protein kinase kinase kinase 20
    Orthology source: HGNC, HomoloGene
  • Synonyms
    AZK, CNM6, MLK7, mlklak, MLT, MLTK, MLTKalpha, MLTKbeta, MRK, pk, SFMMP, ZAK
  • Links
    NCBI Gene ID: 51776
    neXtProt AC: NX_Q9NYL2
    UniProt: Q9NYL2

  • Chr Location
    2q31.1; chr2:173075435-173268009 (+)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with Map3k20 mouse models

Human Disease Mouse Models
      
IDs
View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    8 phenotypes from 2 alleles in 1 genetic background
    19 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit complete lethality at E9.5 with growth retardation. Mice homozygous for an allele lacking the SAM domain exhibit low penetrant unilateral complex hindlimb duplication phenotype.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000013165 VEGA Gene Model | MGI Sequence Detail 156974 C57BL/6J ±  kb
    transcript OTTMUST00000031795 VEGA | MGI Sequence Detail 3334 Not Applicable  
    polypeptide OTTMUSP00000014168 VEGA | MGI Sequence Detail 802 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      1194 from dbSNP Build 142
    Protein
    Information
    less
    • UniProt
      4 Sequences
    • Protein Ontology
      PR:000010457 mitogen-activated protein kinase kinase kinase 20
    • EC
    • InterPro Domains
      IPR032938 Mitogen-activated protein kinase kinase kinase MLT
      IPR000719 Protein kinase domain
      IPR011009 Protein kinase-like domain superfamily
      IPR008271 Serine/threonine-protein kinase, active site
      IPR001245 Serine-threonine/tyrosine-protein kinase, catalytic domain
      IPR001660 Sterile alpha motif domain
      IPR013761 Sterile alpha motif/pointed domain superfamily
    Molecular
    Reagents
    less
    • All nucleic 17
      cDNA 11
      Primer pair 5
      Other 1

      Microarray probesets 7
    Other
    Accession IDs
    less
    MGI:1931274, MGI:2139236
    References
    more
    • Summaries
      All 47
      Developmental Gene Expression 3
      Diseases 1
      Gene Ontology 7
      Phenotypes 19
    • Earliest
      J:21477 Zwacka RM, et al., The glomerulosclerosis gene Mpv17 encodes a peroxisomal protein producing reactive oxygen species. EMBO J. 1994 Nov 1;13(21):5129-34
    • Latest
      J:241322 Jandhyala DM, et al., A Novel Zak Knockout Mouse with a Defective Ribotoxic Stress Response. Toxins (Basel). 2016 Sep 02;8(9)

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    09/11/2018
    MGI 6.12
    The Jackson Laboratory