Automated description from the Alliance of Genome Resources (Release 7.1.0)
Enables ATP binding activity; MAP kinase kinase kinase activity; and magnesium ion binding activity. Involved in MAPK cascade and limb development. Acts upstream of or within cytoskeleton organization. Located in cytoplasm and nucleus. Is expressed in heart; limb; limb bud; and urinary system. Used to study split hand-foot malformation. Human ortholog(s) of this gene implicated in centronuclear myopathy 6 with fiber-type disproportion. Orthologous to human MAP3K20 (mitogen-activated protein kinase kinase kinase 20).