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Gprasp2 Gene Detail
Summary
  • Symbol
    Gprasp2
  • Name
    G protein-coupled receptor associated sorting protein 2
  • Synonyms
    5330440H13Rik, GASP2, Prpl5
  • Feature Type
    protein coding gene
  • IDs
    MGI:2442071
    NCBI Gene: 245607
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    ChrX:134739783-134745479 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome X, 57.30 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    26 from dbSNP Build 142
  • Strain Annotations
    12
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2442071
protein coding gene ChrX:134739783-134745479 (+)
129S1/SvImJ no annotation
A/J MGP_AJ_G0036069
protein coding gene ChrX:132532188-132583976 (+)
AKR/J MGP_AKRJ_G0035995
protein coding gene ChrX:136789479-136843638 (+)
BALB/cJ no annotation
C3H/HeJ MGP_C3HHeJ_G0035769
protein coding gene ChrX:133165840-133175995 (+)
C57BL/6NJ no annotation
CAROLI/EiJ MGP_CAROLIEiJ_G0033410
protein coding gene ChrX:124614307-124619218 (+)
CAST/EiJ MGP_CASTEiJ_G0035056
protein coding gene ChrX:114049385-114099619 (+)
CBA/J MGP_CBAJ_G0035743
protein coding gene ChrX:141213474-141223484 (+)
DBA/2J MGP_DBA2J_G0035899
protein coding gene ChrX:131875941-131933143 (+)
FVB/NJ no annotation
LP/J MGP_LPJ_G0035992
protein coding gene ChrX:134108520-134113276 (+)
NOD/ShiLtJ no annotation
NZO/HlLtJ MGP_NZOHlLtJ_G0036617
protein coding gene ChrX:132534660-132540356 (+)
PWK/PhJ no annotation
SPRET/EiJ MGP_SPRETEiJ_G0034579
protein coding gene ChrX:114725899-114733753 (+)
WSB/EiJ MGP_WSBEiJ_G0035189
protein coding gene ChrX:130873026-130878430 (+)



Homology
more
  • Human Ortholog
    ARMCX5-GPRASP2, ARMCX5-GPRASP2 readthrough
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources

  • Human Ortholog
    GPRASP2, G protein-coupled receptor associated sorting protein 2
  • Synonyms
    DFNX7, GASP2
  • Links
    NCBI Gene ID: 114928
    neXtProt AC: NX_Q96D09
    UniProt: Q96D09

  • Chr Location
    Xq22.1; chrX:102712176-102717733 (+)  GRCh38.p7

Human Diseases
more
  • Diseases
    2 with Gprasp2 mouse models; 1 with human GPRASP2 associations

Human Disease Mouse Models
      
IDs
View 1 model
IDs
View 1 model
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    18 phenotypes from 2 alleles in 2 genetic backgrounds
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Male mice hemizygous for a knock-out allele exhibit increased body weight, autism-like behaviors, alterations in hippocampal pyramidal neuron dendrite complexity, spine density and synaptic maturation, impaired glutamatergic transmission, and enhanced hippocampal long-term depression.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 245607 NCBI Gene Model | MGI Sequence Detail 5697 C57BL/6J ±  kb
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 47
      cDNA 47

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:892978
    References
    more
    • Summaries
      All 35
      Developmental Gene Expression 3
      Diseases 2
      Gene Ontology 5
      Phenotypes 9
    • Earliest
      J:39869 Yehiely F, et al., Identification of candidate proteins binding to prion protein. Neurobiol Dis. 1997;3(4):339-55
    • Latest
      J:289544 Morales-Hernandez A, et al., GPRASP proteins are critical negative regulators of hematopoietic stem cell transplantation. Blood. 2020 Apr 2;135(14):1111-1123

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    last database update
    05/17/2022
    MGI 6.19
    The Jackson Laboratory