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Phenotypes Associated with This Genotype
Genotype
MGI:6287871
Allelic
Composition
Gprasp2tm1.1Jpe/Y
Genetic
Background
B6.129(FVB)-Gprasp2tm1.1Jpe
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gprasp2tm1.1Jpe mutation (0 available); any Gprasp2 mutation (7 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
growth/size/body
• mice show an increase in body weight starting at 12 weeks of age

behavior/neurological
• in the Barnes maze test, mice show an increased latency to find the target during training trails and an increased latency to reach the target region during the probe trial
• mice show altered spontaneous alternation in the T-maze test for working memory
• in the tube test for social dominance, mice show a greater probability of winning by forcing a retreat of the wild-type mice out of the tube
• in a novel object recognition test, mice show decreased time exploring and number of visits to the non-familiar object
• mice spend more time grooming
• total distance traveled in the 3-chamber social arena is greater than for controls
• mice spend more time in the homecage and scrabbling in the open field test
• innate social behavior is perturbed in the nest building test
• in the 3-chamber social arena, mice do show a preference for a social partner compared with an empty cage but their preference index for social interaction is reduced and mice spend less time overall engaging in social interaction with a novel social partner in a subsequent trial and show a lower index of preference for the novel stimulus
• in a social dyadic test, mice engage in more events of non-reciprocal social interaction

nervous system
• CA1 pyramidal neurons show a decrease in density of mature spines in apical regions, indicating impaired neuronal spine maturation
• CA1 pyramidal neurons show a reduction in dendritic arborization and a decrease in total dendritic length
• decrease in the thickness of postsynaptic densities in the CA1 region
• the amplitude of AMPA receptor-mediated miniature excitatory postsynaptic currents (mEPSCs) is reduced
• however, no differences are seen in frequency of mEPSCs or in the kinetics of the miniature events
• field excitatory postsynaptic potential (fEPSP) amplitudes in the CA1 area are reduced while stimulating Shaffer collateral fibers
• stimulation with 3,5-Dihydroxyphenylglycine (DHPG), an mGluR5 receptor agonist, promotes a long-lasting and exacerbated induction of long term depression (LTD) in the CA3-CA1 circuit compared to controls

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
autism spectrum disorder DOID:0060041 J:273373
intellectual disability DOID:1059 J:273373


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
06/12/2024
MGI 6.13
The Jackson Laboratory