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Dock1
Gene Detail
 Symbol
Name
ID
Dock1
dedicator of cytokinesis 1
MGI:2429765
Synonyms 9130006G06Rik, D630004B07Rik, Dock180
Feature Type protein coding gene
Genetic Map
Chromosome 7
79.14 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr7:134670687-135173639 bp, + strand
From Ensembl annotation of GRCm38

  502953 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:55575  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Dock1

Human
homologs
Human Homolog DOCK1, dedicator of cytokinesis 1
NCBI Gene ID 1793
neXtProt AC  NX_Q14185
Human Synonyms  ced5, DOCK180
Human Chr (Location)  10q26.13-q26.3; chr10:126905414-127452516 (+)  GRCh38
Alleles
and
phenotypes
All alleles(72) : Gene trapped(68) Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a null allele exhibit postnatal lethality associated with abnormal muscle development and failure of lungs to inflate.
 
Gene Ontology
(GO)
classifications
All GO classifications: (12 annotations)
Process apoptotic process, cell migration, ...
Component cytoplasm, membrane, ...
Function guanyl-nucleotide exchange factor activity, protein binding, ...
External Resources: FuncBase
Expression
Literature Summary: (2 records)
cDNA source data(21)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(21) cDNA(21)
Microarray probesets(8)
Other database
links
Ensembl Gene ModelENSMUSG00000058325 (Evidence)
Entrez Gene330662 (Evidence)
DFCITC1597139, TC1599655, TC1600546, TC1604795, TC1613837
PDB2M0Y
Consensus CDS ProjectCCDS40166.1
International Mouse Knockout Project StatusDock1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000058325 Ensembl Gene Model | MGI Sequence Detail 502953 C57BL/6J ±  kb
transcript ENSMUST00000084488 Ensembl | MGI Sequence Detail 6807 Not Applicable 
polypeptide ENSMUSP00000081531 Ensembl | MGI Sequence Detail 1865 Not Applicable 

For the selected sequences
All sequences(41) RefSeq(4) UniProt(1)
Polymorphisms SNPs within 2kb(4710 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR016024 Armadillo-type fold
InterPro IPR026791 Dedicator of cytokinesis
InterPro IPR010703 Dedicator of cytokinesis C-terminal
InterPro IPR027007 DHR-1 domain
InterPro IPR027357 DHR-2 domain
InterPro IPR001452 Src homology-3 domain
Protein Ontology PR:000006616 dedicator of cytokinesis protein 1
References (Earliest) J:93290 Araki K, et al., Exchangeable gene trap using the Cre/mutated lox system. Cell Mol Biol (Noisy-le-grand). 1999 Jul;45(5):737-50
(Latest) J:202604 Nagamachi A, et al., Haploinsufficiency of SAMD9L, an endosome fusion facilitator, causes myeloid malignancies in mice mimicking human diseases with monosomy 7. Cancer Cell. 2013 Sep 9;24(3):305-17
All references(43)
Other
accession IDs
MGI:1918821, MGI:2142074, MGI:2442765

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory