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Dock1
Gene Detail
Symbol

Name
ID
Dock1
dedicator of cytokinesis 1
MGI:2429765
Synonyms
9130006G06Rik, D630004B07Rik, Dock180
Feature Type
protein coding gene
Genetic Map
Chromosome 7
79.14 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr7:134670687-135173639 bp, + strand
From Ensembl annotation of GRCm38

  502953 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:55575  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: DOCK1
Gene Tree: Dock1

Human
homologs
DOCK1, dedicator of cytokinesis 1
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 1793
neXtProt AC: NX_Q14185

Human Synonyms: ced5, DOCK180

Human Chr (Location): 10q26.13-q26.3; chr10:126905409-127452517 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(72) : Gene trapped(68) Targeted(4)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Mice homozygous for a null allele exhibit postnatal lethality associated with abnormal muscle development and failure of lungs to inflate.
 
Interactions
Dock1 interacts with 240 markers (Mir7-1, Mir10a, Mir10b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (15 annotations)
Process apoptotic process, cell migration, ...
Component cytoplasm, membrane, ...
Function GTPase activator activity, guanyl-nucleotide exchange factor activity, ...
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (2)    Tissues (2)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 2
cDNA source data(21)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase dock1 ; ZFIN dock1    NEW 
Molecular
reagents
All nucleic(21) cDNA(21)
Microarray probesets(8)
Other database
links
Ensembl Gene Model ENSMUSG00000058325 (Evidence)
Entrez Gene 330662 (Evidence)
DFCI TC1613837, TC1599655, TC1597139, TC1604795, TC1600546
PDB 2M0Y
Consensus CDS Project CCDS40166.1
International Mouse Phenotyping Consortium Status Dock1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000058325 Ensembl Gene Model | MGI Sequence Detail 502953 C57BL/6J ±  kb
transcript ENSMUST00000084488 Ensembl | MGI Sequence Detail 6807 Not Applicable 
polypeptide ENSMUSP00000081531 Ensembl | MGI Sequence Detail 1865 Not Applicable 

For the selected sequences
All sequences(41) RefSeq(4) UniProt(1)
Polymorphisms
SNPs within 2kb(4710 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR016024 Armadillo-type fold
InterPro IPR026791 Dedicator of cytokinesis
InterPro IPR010703 Dedicator of cytokinesis C-terminal
InterPro IPR027007 DHR-1 domain
InterPro IPR027357 DHR-2 domain
InterPro IPR001452 Src homology-3 domain
Protein Ontology PR:000006616 dedicator of cytokinesis protein 1
References
(Earliest) J:93290 Araki K, et al., Exchangeable gene trap using the Cre/mutated lox system. Cell Mol Biol (Noisy-le-grand). 1999 Jul;45(5):737-50
(Latest) J:202604 Nagamachi A, et al., Haploinsufficiency of SAMD9L, an endosome fusion facilitator, causes myeloid malignancies in mice mimicking human diseases with monosomy 7. Cancer Cell. 2013 Sep 9;24(3):305-17
All references(41)
Other
accession IDs
MGI:1918821, MGI:2142074, MGI:2442765

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory