Dock1 Phenotype Annotations - Multigenic Genotypes

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Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Dock1
dedicator of cytokinesis 1
MGI:2429765

11 phenotypes from multigenic genotypes

Allelic Composition Genetic Background	Annotated Term	Reference
Dock1^tm1Jfco/Dock1⁺ Dock5^{Gt(AN0268)Wtsi}/Dock5⁺ involves: 129/Sv * 129P2/OlaHsd * C57BL/6	normal muscle phenotype	J:143342
Dock1^tm1Jfco/Dock1⁺ Dock5^{Gt(AN0268)Wtsi}/Dock5^{Gt(AN0268)Wtsi} involves: 129/Sv * 129P2/OlaHsd * C57BL/6	decreased skeletal muscle fiber diameter	J:143342
Dock1^tm1Jfco/Dock1^tm1Jfco Dock5^{Gt(AN0268)Wtsi}/Dock5^{Gt(AN0268)Wtsi} involves: 129/Sv * 129P2/OlaHsd * C57BL/6	abnormal embryo development	J:143342
	lethality throughout fetal growth and development, complete penetrance	J:143342
Dock1^tm2.1Jfco/Dock1⁺ Tg(MMTV-Erbb2,-cre)1Mul/0 involves: C57BL/6 FVB/NJ	increased mammary adenocarcinoma incidence	J:196659
	increased mammary gland tumor incidence	J:196659
	increased tumor latency	J:196659
Dock1^tm2.1Jfco/Dock1^tm2.1Jfco Tg(MMTV-Erbb2,-cre)1Mul/0 involves: C57BL/6 FVB/NJ	decreased cell proliferation	J:196659
	decreased metastatic potential	J:196659
	decreased tumor growth/size	J:196659
	increased apoptosis	J:196659
	increased mammary adenocarcinoma incidence	J:196659
	increased mammary gland tumor incidence	J:196659
	increased tumor latency	J:196659

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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