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Tbx22
Gene Detail
 Symbol
Name
ID
Tbx22
T-box 22
MGI:2389465
Synonyms D230020M15Rik
Feature Type protein coding gene
Genetic Map
Chromosome X
47.59 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
ChrX:107667964-107688978 bp, + strand
From VEGA annotation of GRCm38

  21015 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:9666  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 chicken

Gene Tree: Tbx22

Human
homologs
Human Homolog TBX22, T-box 22
NCBI Gene ID 50945
neXtProt AC  NX_Q9Y458
Human Synonyms  ABERS, CLPA, CPX, dJ795G23.1, TBXX
Human Chr (Location)  Xq21.1; chrX:80014756-80035752 (+)  GRCh38
Disease Associations  (2) Diseases Associated with Human TBX22
Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Targeted(4)
Incidental mutations (data from Mutagenetix )
 
Half of homozygous female and hemizygous male null mice die neonatally due to breathing or feeding deficits, and show reduced bone formation in the posterior hard palate leading to submucous cleft palate, ankyloglossia, persistent oro-nasal membranes andoccasional overt clefts and choanal atresia.
 
Human Diseases Modeled Using Mouse Tbx22 (1)    Alleles Annotated to Human Diseases(1)   
Interactions
Tbx22 interacts with 381 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (8 annotations)
Process negative regulation of transcription, DNA-templated, negative regulation of transcription from RNA polymerase II promoter, ...
Component nucleus
Function DNA binding, sequence-specific DNA binding transcription factor activity
External Resources: FuncBase
Expression
Literature Summary: (21 records)
Data Summary: Results (169)    Tissues (129)    Images (42)
Theiler Stages: 13, 15, 17, 19, 20, 21, 22, 23, 28
Assay TypeResults
RNA in situ 154
Northern blot 1
RT-PCR 14
cDNA source data(9)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(14) cDNA(9) Primer pair(4) Other(1)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000018237 (Evidence)
Ensembl Gene ModelENSMUSG00000031241 (Evidence)
Entrez Gene245572 (Evidence)
UniGene137011
DFCITC1587284, TC1596468
DoTSDT.60104592, DT.94131691, DT.97348008
NIA Mouse Gene IndexU020134
Consensus CDS ProjectCCDS30350.1, CCDS30351.2, CCDS72420.1
International Mouse Knockout Project StatusTbx22
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000018237 VEGA Gene Model | MGI Sequence Detail 21015 C57BL/6J ±  kb
transcript OTTMUST00000044073 VEGA | MGI Sequence Detail 5217 Not Applicable 
polypeptide OTTMUSP00000019812 VEGA | MGI Sequence Detail 531 Not Applicable 

For the selected sequences
All sequences(67) RefSeq(24) UniProt(4)
Polymorphisms PCR(1) : SNPs within 2kb(141 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR008967 p53-like transcription factor, DNA-binding
InterPro IPR001699 Transcription factor, T-box
InterPro IPR018186 Transcription factor, T-box, conserved site
Protein Ontology PR:000016150 T-box transcription factor TBX22
References (Earliest) J:79619 Braybrook C, et al., Craniofacial expression of human and murine TBX22 correlates with the cleft palate and ankyloglossia phenotype observed in CPX patients. Hum Mol Genet. 2002 Oct 15;11(22):2793-804
(Latest) J:198588 Yumoto K, et al., TGF-beta-activated kinase 1 (Tak1) mediates agonist-induced Smad activation and linker region phosphorylation in embryonic craniofacial neural crest-derived cells. J Biol Chem. 2013 May 10;288(19):13467-80
All references(46)
Disease annotation references (1)
Other
accession IDs
MGI:2444683

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/12/2014
MGI 5.19
The Jackson Laboratory