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Tbx22
Gene Detail
Symbol

Name
ID
Tbx22
T-box 22
MGI:2389465
Synonyms
D230020M15Rik
Feature Type
protein coding gene
Genetic Map
Chromosome X
47.59 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
ChrX:107667964-107688978 bp, + strand
From VEGA annotation of GRCm38

  21015 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:9666  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 chicken; 1 western clawed frog

HCOP human homology predictions: TBX22
Gene Tree: Tbx22

Human
homologs
TBX22, T-box 22
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 50945
neXtProt AC: NX_Q9Y458

Human Synonyms: ABERS, CLPA, CPX, dJ795G23.1, TBXX

Human Chr (Location): Xq21.1; chrX:80014728-80035828 (+)  GRCh38.p2

Disease Associations: (2) Diseases Associated with Human TBX22

Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Targeted(4)
Incidental mutations (data from Mutagenetix , CvDC )
 
Half of homozygous female and hemizygous male null mice die neonatally due to breathing or feeding deficits, and show reduced bone formation in the posterior hard palate leading to submucous cleft palate, ankyloglossia, persistent oro-nasal membranes andoccasional overt clefts and choanal atresia.
 
Human Diseases Modeled in Mice Using Tbx22 (1)    Mutations Annotated to Human Diseases (1)   
Interactions
Tbx22 interacts with 381 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Expression
Literature Summary: (22 records)
Data Summary: Results (169)    Tissues (129)    Images (42)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 154
Northern blot 1
RT-PCR 14
cDNA source data(9)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: GEISHA TBX22 ; Xenbase tbx22 ; ZFIN tbx22    NEW 
Molecular
reagents
All nucleic(14) cDNA(9) Primer pair(4) Other(1)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000018237 (Evidence)
Ensembl Gene Model ENSMUSG00000031241 (Evidence)
Entrez Gene 245572 (Evidence)
UniGene 137011
DFCI TC1596468, TC1587284
DoTS DT.60104592, DT.94131691, DT.97348008
NIA Mouse Gene Index U020134
Consensus CDS Project CCDS30350.1, CCDS30351.2, CCDS72420.1
International Mouse Phenotyping Consortium Status Tbx22
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000018237 VEGA Gene Model | MGI Sequence Detail 21015 C57BL/6J ±  kb
transcript OTTMUST00000044073 VEGA | MGI Sequence Detail 5217 Not Applicable 
polypeptide OTTMUSP00000019812 VEGA | MGI Sequence Detail 531 Not Applicable 

For the selected sequences
All sequences(67) RefSeq(24) UniProt(4)
Polymorphisms
PCR(1) : SNPs within 2kb(141 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR008967 p53-like transcription factor, DNA-binding
InterPro IPR001699 Transcription factor, T-box
InterPro IPR018186 Transcription factor, T-box, conserved site
Protein Ontology PR:000016150 T-box transcription factor TBX22
References
(Earliest) J:79619 Braybrook C, et al., Craniofacial expression of human and murine TBX22 correlates with the cleft palate and ankyloglossia phenotype observed in CPX patients. Hum Mol Genet. 2002 Oct 15;11(22):2793-804
(Latest) J:214981 Matsui M, et al., Multiple tissue-specific requirements for the BMP antagonist Noggin in development of the mammalian craniofacial skeleton. Dev Biol. 2014 Aug 15;392(2):168-81
All references(46)
Disease annotation references (1)
Other
accession IDs
MGI:2444683

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory