Lrrtm1
Gene Detail

Symbol Name ID

Lrrtm1 leucine rich repeat transmembrane neuronal 1 MGI:2389173

Synonyms

4632401D06Rik

Feature Type

protein coding gene

Genetic Map

Chromosome 6

33.89 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr6:77242689-77257791 bp, + strand From VEGA annotation of GRCm38   15103 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:41763  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Lrrtm1

Human homologs

Human Homolog		LRRTM1, leucine rich repeat transmembrane neuronal 1
NCBI Gene ID		347730
neXtProt AC		NX_Q86UE6
Human Chr (Location)		2p12; chr2:80529003-80531487 (-)  GRCh37.p10

Alleles and phenotypes

All alleles(3) : Targeted(3)
 

Mice homozygous for a null mutation are viable and fertile with grossly normal brain morphology. Mice homozygous for another knock-out allele exhibit impaired cognitive function and altered hippocampal synapse morphology.

 
Human Diseases Modeled Using Mouse Lrrtm1 (1)    Alleles Annotated to Human Diseases(1)    Phenotype Images(2)

Gene Ontology (GO) classifications

All GO classifications: (16 annotations)

Process	locomotory behavior, protein localization to synapse, ...
Component	axon, cell junction, ...
Function	molecular_function

This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase

Expression

Literature Summary: (6 records)
Data Summary: Results (295)    Tissues (99)    Images (51)
Theiler Stages: 14, 16, 18, 19, 23, 28

Assay Type	Results
RNA in situ	295

cDNA source data(22)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress

Molecular reagents

All nucleic(22) cDNA(22)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000034534 (Evidence)
Ensembl Gene Model	ENSMUSG00000060780 (Evidence)
Entrez Gene	74342 (Evidence)
UniGene	292568
DFCI	TC1578014
DoTS	DT.110482407, DT.486179, DT.55257269, DT.87048467
NIA Mouse Gene Index	U235556
Consensus CDS Project	CCDS39522.1
International Mouse Knockout Project Status	Lrrtm1

Sequences

Length	Strain/Species
genomic	OTTMUSG00000034534	VEGA Gene Model | MGI Sequence Detail	15103	C57BL/6J
transcript	OTTMUST00000087620	VEGA | MGI Sequence Detail	2541	Not Applicable
polypeptide	OTTMUSP00000047684	VEGA | MGI Sequence Detail	522	Not Applicable

All sequences(41) RefSeq(2) UniProt(2)

Polymorphisms

SNPs(2 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR001611	Leucine-rich repeat
InterPro	IPR000372	Leucine-rich repeat-containing N-terminal
InterPro	IPR003591	Leucine-rich repeat, typical subtype
Protein Ontology	PR:000009946	leucine-rich repeat transmembrane neuronal protein 1

References

(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:176974 Ko J, et al., Neuroligins/LRRTMs prevent activity- and Ca2+/calmodulin-dependent synapse elimination in cultured neurons. J Cell Biol. 2011 Jul 25;194(2):323-34
All references(38)

Other accession IDs

MGI:1921592, MGI:2141653