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Lrrtm1
Gene Detail
Symbol

Name
ID
Lrrtm1
leucine rich repeat transmembrane neuronal 1
MGI:2389173
Synonyms
4632401D06Rik
Feature Type
protein coding gene
Genetic Map
Chromosome 6
33.89 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr6:77242689-77257791 bp, + strand
From VEGA annotation of GRCm38

  15103 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:41763  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: LRRTM1
Gene Tree: Lrrtm1

Human
homologs
LRRTM1, leucine rich repeat transmembrane neuronal 1
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 347730
neXtProt AC: NX_Q86UE6

Human Chr (Location): 2p12; chr2:80288280-80304593 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Spontaneous(1) Targeted(3)
Genomic Mutations involving Lrrtm1 (1)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a null mutation are viable and fertile with grossly normal brain morphology. Mice homozygous for another knock-out allele exhibit impaired cognitive function and altered hippocampal synapse morphology.
 
Human Diseases Modeled in Mice Using Lrrtm1 (1)    Mutations Annotated to Human Diseases (1)    Phenotype Images(2)
Interactions
Lrrtm1 interacts with 171 markers (Mir7-1, Mir9-1, Mir9-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (20 annotations)
Process exploration behavior, locomotory behavior, ...
Component axon, cell junction, ...
Function molecular_function
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (6 records)
Data Summary: Results (295)    Tissues (99)    Images (51)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 295
cDNA source data(21)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Other vertebrate links: Xenbase LOC100493874    NEW 
Molecular
reagents
All nucleic(21) cDNA(21)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000034534 (Evidence)
Ensembl Gene Model ENSMUSG00000060780 (Evidence)
Entrez Gene 74342 (Evidence)
UniGene 292568
DFCI TC1578014
DoTS DT.110482407, DT.87048467, DT.55257269, DT.486179
NIA Mouse Gene Index U235556
Consensus CDS Project CCDS39522.1
International Mouse Phenotyping Consortium Status Lrrtm1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000034534 VEGA Gene Model | MGI Sequence Detail 15103 C57BL/6J ±  kb
transcript OTTMUST00000087620 VEGA | MGI Sequence Detail 2541 Not Applicable 
polypeptide OTTMUSP00000047684 VEGA | MGI Sequence Detail 522 Not Applicable 

For the selected sequences
All sequences(44) RefSeq(5) UniProt(2)
Polymorphisms
SNPs within 2kb(90 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001611 Leucine-rich repeat
InterPro IPR000372 Leucine-rich repeat-containing N-terminal
InterPro IPR003591 Leucine-rich repeat, typical subtype
Protein Ontology PR:000009946 leucine-rich repeat transmembrane neuronal protein 1
References
(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:211830 Um JW, et al., Calsyntenins function as synaptogenic adhesion molecules in concert with neurexins. Cell Rep. 2014 Mar 27;6(6):1096-109
All references(40)
Disease annotation references (1)
Other
accession IDs
MGI:1921592, MGI:2141653

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory