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Lrrtm1
Gene Detail
 Symbol
Name
ID
Lrrtm1
leucine rich repeat transmembrane neuronal 1
MGI:2389173
Synonyms 4632401D06Rik
Feature Type protein coding gene
Genetic Map
Chromosome 6
33.89 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr6:77242689-77257791 bp, + strand
From VEGA annotation of GRCm38

  15103 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:41763  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Lrrtm1

Human
homologs
Human Homolog LRRTM1, leucine rich repeat transmembrane neuronal 1
NCBI Gene ID 347730
neXtProt AC  NX_Q86UE6
Human Chr (Location)  2p12; chr2:80288356-80304593 (-)  GRCh38
Alleles
and
phenotypes
All alleles(3) : Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a null mutation are viable and fertile with grossly normal brain morphology. Mice homozygous for another knock-out allele exhibit impaired cognitive function and altered hippocampal synapse morphology.
 
Human Diseases Modeled Using Mouse Lrrtm1 (1)    Alleles Annotated to Human Diseases(1)    Phenotype Images(2)
Gene Ontology
(GO)
classifications
All GO classifications: (19 annotations)
Process exploration behavior, locomotory behavior, ...
Component axon, cell junction, ...
Function molecular_function
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (6 records)
Data Summary: Results (295)    Tissues (99)    Images (51)
Theiler Stages: 14, 16, 18, 19, 23, 28
Assay TypeResults
RNA in situ 295
cDNA source data(21)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress
Molecular
reagents
All nucleic(21) cDNA(21)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000034534 (Evidence)
Ensembl Gene ModelENSMUSG00000060780 (Evidence)
Entrez Gene74342 (Evidence)
UniGene292568
DFCITC1578014
DoTSDT.110482407, DT.486179, DT.55257269, DT.87048467
NIA Mouse Gene IndexU235556
Consensus CDS ProjectCCDS39522.1
International Mouse Knockout Project StatusLrrtm1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000034534 VEGA Gene Model | MGI Sequence Detail 15103 C57BL/6J ±  kb
transcript OTTMUST00000087620 VEGA | MGI Sequence Detail 2541 Not Applicable 
polypeptide OTTMUSP00000047684 VEGA | MGI Sequence Detail 522 Not Applicable 

For the selected sequences
All sequences(44) RefSeq(5) UniProt(2)
Polymorphisms SNPs within 2kb(90 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001611 Leucine-rich repeat
InterPro IPR000372 Leucine-rich repeat-containing N-terminal
InterPro IPR003591 Leucine-rich repeat, typical subtype
Protein Ontology PR:000009946 leucine-rich repeat transmembrane neuronal protein 1
References (Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:201652 Soler-Llavina GJ, et al., Leucine-rich repeat transmembrane proteins are essential for maintenance of long-term potentiation. Neuron. 2013 Aug 7;79(3):439-46
All references(40)
Other
accession IDs
MGI:1921592, MGI:2141653

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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Funding Information
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory