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Lrrtm1 Gene Detail
Summary
  • Symbol
    Lrrtm1
  • Name
    leucine rich repeat transmembrane neuronal 1
  • Synonyms
    4632401D06Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:2389173
    NCBI Gene: 74342
  • Gene Overview
    MyGene.info: LRRTM1
Location & Maps
more
  • Sequence Map
    Chr6:77242689-77257791 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      15103 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 6, 33.89 cM
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    LRRTM1, leucine rich repeat transmembrane neuronal 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    LRRTM1, leucine rich repeat transmembrane neuronal 1
    Orthology source: HGNC, HomoloGene
  • Links
    NCBI Gene ID: 347730
    neXtProt AC: NX_Q86UE6

  • Chr Location
    2p12; chr2:80288280-80304593 (-)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with Lrrtm1 mouse models

Human Disease Mouse Models
       Schizophrenia; SCZD   OMIM: 181500 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    16 phenotypes from 2 alleles in 2 genetic backgrounds
    2 images
    7 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    4
  • Spontaneous
    1
  • Targeted
    3
  • Genomic Mutations
    1 involving Lrrtm1
  • Incidental Mutations
Mice homozygous for a null mutation are viable and fertile with grossly normal brain morphology. Mice homozygous for another knock-out allele exhibit impaired cognitive function and altered hippocampal synapse morphology.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000034534 VEGA Gene Model | MGI Sequence Detail 15103 C57BL/6J ±  kb
transcript OTTMUST00000087620 VEGA | MGI Sequence Detail 2541 Not Applicable  
polypeptide OTTMUSP00000047684 VEGA | MGI Sequence Detail 522 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    89 from dbSNP Build 142
Protein
Information
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  • UniProt
    2 Sequences
  • Protein Ontology
    PR:000009946 leucine-rich repeat transmembrane neuronal protein 1
  • InterPro Domains
    IPR001611 Leucine-rich repeat
    IPR032675 Leucine-rich repeat domain, L domain-like
    IPR003591 Leucine-rich repeat, typical subtype
Molecular
Reagents
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  • All nucleic 21
    cDNA 21

    Microarray probesets 3
Other
Accession IDs
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MGI:1921592, MGI:2141653
References
more
  • Summaries
    All 37
    Developmental Gene Expression 6
    Diseases 1
    Gene Ontology 11
    Phenotypes 7
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:211830 Um JW, et al., Calsyntenins function as synaptogenic adhesion molecules in concert with neurexins. Cell Rep. 2014 Mar 27;6(6):1096-109

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/12/2016
MGI 6.04
The Jackson Laboratory