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Lrrtm1 Gene Detail
Summary
  • Symbol
    Lrrtm1
  • Name
    leucine rich repeat transmembrane neuronal 1
  • Synonyms
    4632401D06Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:2389173
    NCBI Gene: 74342
  • Gene Overview
    MyGene.info: LRRTM1
  • Alliance
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:77242689-77257791 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 6, 33.89 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    89 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2389173
protein coding gene Chr6:77242480-77259915 (.)
129S1/SvImJ MGP_129S1SvImJ_G0030891
protein coding gene Chr6:78031276-78046212 (+)
A/J MGP_AJ_G0030860
protein coding gene Chr6:74964020-74979071 (+)
AKR/J MGP_AKRJ_G0030789
protein coding gene Chr6:77215445-77230672 (+)
BALB/cJ MGP_BALBcJ_G0030871
protein coding gene Chr6:75053133-75069587 (+)
C3H/HeJ MGP_C3HHeJ_G0030842
protein coding gene Chr6:107055780-107070750 (-)
C57BL/6NJ MGP_C57BL6NJ_G0031329
protein coding gene Chr6:80098911-80113768 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0028518
protein coding gene Chr6:73830881-73846101 (+)
CAST/EiJ MGP_CASTEiJ_G0029979
protein coding gene Chr6:77138108-77153022 (+)
CBA/J MGP_CBAJ_G0030558
protein coding gene Chr6:83295250-83310213 (+)
DBA/2J MGP_DBA2J_G0030710
protein coding gene Chr6:74361608-74376544 (+)
FVB/NJ MGP_FVBNJ_G0030663
protein coding gene Chr6:73635088-73651037 (+)
LP/J MGP_LPJ_G0030790
protein coding gene Chr6:77944901-77959744 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0030698
protein coding gene Chr6:87280727-87297526 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0031355
protein coding gene Chr6:77066032-77080944 (+)
PWK/PhJ MGP_PWKPhJ_G0029695
protein coding gene Chr6:73318085-73333158 (+)
SPRET/EiJ MGP_SPRETEiJ_G0029523
protein coding gene Chr6:75838840-75853640 (+)
WSB/EiJ MGP_WSBEiJ_G0030061
protein coding gene Chr6:77428107-77444989 (+)



Homology
more
  • Human Ortholog
    LRRTM1, leucine rich repeat transmembrane neuronal 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    LRRTM1, leucine rich repeat transmembrane neuronal 1
    Orthology source: HomoloGene, HGNC
  • Links
    NCBI Gene ID: 347730
    neXtProt AC: NX_Q86UE6
    UniProt: Q86UE6

  • Chr Location
    2p12; chr2:80301878-80304738 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 41763
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: LRRTM1
  • Gene Tree
Human Diseases
more
  • Diseases
    1 with Lrrtm1 mouse models

Human Disease Mouse Models
      
IDs
View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    16 phenotypes from 2 alleles in 2 genetic backgrounds
    4 phenotypes from multigenic genotypes
    2 images
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit impaired cognitive function and altered hippocampal synapse morphology. When conditionally deleted in addition to Lrrtm2, mice homozygous for a conditional allele exhibit impaired basal AMPA receptor transmission and LTP.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000060780 Ensembl Gene Model | MGI Sequence Detail 15103 C57BL/6J ±  kb
    transcript ENSMUST00000159616 Ensembl | MGI Sequence Detail 2541 Not Applicable  
    polypeptide ENSMUSP00000125207 Ensembl | MGI Sequence Detail 522 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 22
      cDNA 22

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:1921592, MGI:2141653
    References
    more
    • Summaries
      All 45
      Developmental Gene Expression 7
      Diseases 1
      Gene Ontology 13
      Phenotypes 10
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:263280 Monavarfeshani A, et al., LRRTM1 underlies synaptic convergence in visual thalamus. Elife. 2018 Feb 9;7

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory