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Card14 Gene Detail
Summary
  • Symbol
    Card14
  • Name
    caspase recruitment domain family, member 14
  • Synonyms
    Bimp2, CARMA2
  • Feature Type
    protein coding gene
  • IDs
    MGI:2386258
    NCBI Gene: 170720
  • Alliance
    genome feature page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:119198594-119236201 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 83.36 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    1033 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2386258
 protein coding gene Chr11:119197923-119236205 (+)
129S1/SvImJ ENSMUSG00200049834
 protein coding gene Chr11:116566385-116604005 (+)
A/J ENSMUSG00195029535
 protein coding gene Chr11:116241342-116278954 (+)
AKR/J ENSMUSG00220025421
 protein coding gene Chr11:116391732-116429339 (+)
BALB/cJ ENSMUSG00180049863
 protein coding gene Chr11:116535988-116569794 (+)
C3H/HeJ ENSMUSG00175035096
 protein coding gene Chr11:116493502-116527471 (+)
C57BL/6NJ ENSMUSG00215041445
 protein coding gene Chr11:116061931-116099546 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0017496
 protein coding gene Chr11:115203137-115240369 (+)
CAST/EiJ ENSTCUG00005027189
 protein coding gene Chr11:115919118-115955020 (+)
CBA/J ENSMUSG00210047701
 protein coding gene Chr11:116207600-116241558 (+)
DBA/2J ENSMUSG00185022478
 protein coding gene Chr11:116520706-116554667 (+)
FVB/NJ ENSMUSG00205036274
 protein coding gene Chr11:116368208-116404036 (+)
JF1/MsJ ENSUMUG00000024596
 protein coding gene Chr11:116812857-116849438 (+)
LP/J ENSMUSG00230049960
 protein coding gene Chr11:117586564-117620523 (+)
NOD/ShiLtJ ENSMUSG00190034664
 protein coding gene Chr11:116590357-116627964 (+)
NZO/HlLtJ ENSMUSG00225050892
 protein coding gene Chr11:119734009-119771611 (+)
PWK/PhJ ENSLUMG00010020659
 protein coding gene Chr11:116324183-116360433 (+)
SPRET/EiJ ENSMSPG00010042344
 protein coding gene Chr11:116914641-116941102 (+)
WSB/EiJ ENSIUOG00005044651
 protein coding gene Chr11:116326776-116362777 (+)



Homology
more
  • Human Ortholog
    CARD14, caspase recruitment domain family member 14
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CARD14, caspase recruitment domain family member 14
  • Synonyms
    BIMP2, CARMA2, PRP, PSORS2, PSS1
  • Links
    NCBI Gene ID: 79092
    UniProt: Q9BXL6

  • Chr Location
    17q25.3; chr17:80169992-80216073 (+)  GRCh38
Human Diseases
more
  • Diseases
    2 with Card14 mouse models; 2 with human CARD14 associations

Human Disease Mouse Models
      
IDs
 View 1 model
IDs
 View 2 models
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    3 with disease annotations
  • References
    3 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    34 phenotypes from 7 alleles in 6 genetic backgrounds
    2 phenotypes from multigenic genotypes
    20 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice show resistance to IMQ-induced psoriasiform disease. Heterozygotes for a gain-of-function allele develop chronic psoriasis with scaly lesions, epidermal thickening, keratinocyte hyperproliferation, hyperkeratosis and skin inflammation while homozygotes die within days of birth.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    24
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    627
  • Tissues
    6
  • cDNA Data
    10
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000013483 Ensembl Gene Model | MGI Sequence Detail 37608 C57BL/6J ±  kb
    transcript ENSMUST00000053245 Ensembl | MGI Sequence Detail 3958 Not Applicable  
    polypeptide ENSMUSP00000053665 Ensembl | MGI Sequence Detail 999 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 10
      cDNA 10

      Microarray probesets 2
    References
    more
    • Summaries
      All 44
      Developmental Gene Expression 1
      Diseases 3
      Gene Ontology 6
      Phenotypes 20
    • Earliest
      J:71748 McAllister-Lucas LM, et al., Bimp1, a MAGUK family member linking protein kinase C activation to Bcl10-mediated NF-kappaB induction. J Biol Chem. 2001 Aug 17;276(33):30589-97
    • Latest
      J:381879 Tsokkou P, et al., Psoriasis-like disease prevents squamous skin tumor development by neutrophil-driven inflammation. Proc Natl Acad Sci U S A. 2026 Mar 17;123(11):e2536378123
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory