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Card14 Gene Detail
Summary
  • Symbol
    Card14
  • Name
    caspase recruitment domain family, member 14
  • Synonyms
    Bimp2, CARMA2
  • Feature Type
    protein coding gene
  • IDs
    MGI:2386258
    NCBI Gene: 170720
  • Alliance
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:119198594-119236201 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 11, 83.36 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    167 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2386258
protein coding gene Chr11:119197923-119236205 (+)
129S1/SvImJ MGP_129S1SvImJ_G0019479
protein coding gene Chr11:123687501-123728489 (+)
A/J MGP_AJ_G0019447
protein coding gene Chr11:118210092-118245358 (+)
AKR/J MGP_AKRJ_G0019417
protein coding gene Chr11:121768332-121804085 (+)
BALB/cJ MGP_BALBcJ_G0019422
protein coding gene Chr11:118567991-118601696 (+)
C3H/HeJ MGP_C3HHeJ_G0019228
protein coding gene Chr11:122084075-122119163 (+)
C57BL/6NJ MGP_C57BL6NJ_G0019871
protein coding gene Chr11:127459958-127500353 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0017496
protein coding gene Chr11:115203137-115240369 (+)
CAST/EiJ MGP_CASTEiJ_G0018782
protein coding gene Chr11:123542407-123589251 (+)
CBA/J MGP_CBAJ_G0019199
protein coding gene Chr11:132415105-132454110 (+)
DBA/2J MGP_DBA2J_G0019311
protein coding gene Chr11:117582444-117615794 (+)
FVB/NJ MGP_FVBNJ_G0019303
protein coding gene Chr11:117249082-117287949 (+)
LP/J MGP_LPJ_G0019383
protein coding gene Chr11:123998008-124049880 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0019336
protein coding gene Chr11:131345485-131385893 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0019910
protein coding gene Chr11:122442180-122484908 (+)
PWK/PhJ MGP_PWKPhJ_G0018548
protein coding gene Chr11:118988158-119024598 (+)
SPRET/EiJ MGP_SPRETEiJ_G0018340
protein coding gene Chr11:122197654-122240607 (+)
WSB/EiJ MGP_WSBEiJ_G0018834
protein coding gene Chr11:122416469-122467249 (+)



Homology
more
  • Human Ortholog
    CARD14, caspase recruitment domain family member 14
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CARD14, caspase recruitment domain family member 14
  • Synonyms
    BIMP2, CARMA2, PRP, PSORS2, PSS1
  • Links
    NCBI Gene ID: 79092
    neXtProt AC: NX_Q9BXL6
    UniProt: Q9BXL6

  • Chr Location
    17q25.3; chr17:80169992-80216073 (+)  GRCh38

Human Diseases
more
  • Diseases
    1 with Card14 mouse models; 2 with human CARD14 associations

Human Disease Mouse Models
      
IDs
View 2 models
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    21 phenotypes from 5 alleles in 4 genetic backgrounds
    2 phenotypes from multigenic genotypes
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice show resistance to IMQ-induced psoriasiform disease. Heterozygotes for a gain-of-function allele develop chronic psoriasis with scaly lesions, epidermal thickening, keratinocyte hyperproliferation, hyperkeratosis and skin inflammation while homozygotes die within days of birth.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Sequences &
    Gene Models
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    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000013483 Ensembl Gene Model | MGI Sequence Detail 37608 C57BL/6J ±  kb
    transcript ENSMUST00000106250 Ensembl | MGI Sequence Detail 4206 Not Applicable  
    polypeptide ENSMUSP00000101857 Ensembl | MGI Sequence Detail 999 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 10
      cDNA 10

      Microarray probesets 2
    References
    more
    • Summaries
      All 33
      Developmental Gene Expression 1
      Diseases 2
      Gene Ontology 4
      Phenotypes 13
    • Earliest
      J:71748 McAllister-Lucas LM, et al., Bimp1, a MAGUK family member linking protein kinase C activation to Bcl10-mediated NF-kappaB induction. J Biol Chem. 2001 Aug 17;276(33):30589-97
    • Latest
      J:332410 Del Rio Oliva M, et al., Immunoproteasome inhibition attenuates experimental psoriasis. Front Immunol. 2022;13:1075615

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    last database update
    03/12/2024
    MGI 6.23
    The Jackson Laboratory