Flvcr2 MGI Mouse Gene Detail - MGI:2384974 - feline leukemia virus subgroup C cellular receptor 2

Symbol

Flvcr2
Name

feline leukemia virus subgroup C cellular receptor 2
Synonyms

CCT, Mfsd7c, MGC:19050

Feature Type

protein coding gene
IDs

MGI:2384974
NCBI Gene: 217721
Alliance

genome feature page
Transcription Start Sites

5 TSS

Sequence Map

Chr12:85793313-85860359 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 12, 39.80 cM
Mapping Data

2 experiments

SNPs within 2kb

1900 from dbSNP Build 142
Strain Annotations

19

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2384974	protein coding gene	Chr12:85793313-85860359 (+)
129S1/SvImJ	ENSMUSG00200048334	protein coding gene	Chr12:77808535-77875591 (+)
A/J	ENSMUSG00195028502	protein coding gene	Chr12:80428194-80495250 (+)
AKR/J	ENSMUSG00220048833	protein coding gene	Chr12:78224128-78291192 (+)
BALB/cJ	ENSMUSG00180019536	protein coding gene	Chr12:79465923-79532979 (+)
C3H/HeJ	ENSMUSG00175037248	protein coding gene	Chr12:82558977-82626028 (+)
C57BL/6NJ	ENSMUSG00215042474	protein coding gene	Chr12:78772386-78839433 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0017970	protein coding gene	Chr12:80146462-80216810 (+)
CAST/EiJ	ENSTCUG00005027230	protein coding gene	Chr12:78733811-78800617 (+)
CBA/J	ENSMUSG00210041058	protein coding gene	Chr12:78972168-79039226 (+)
DBA/2J	ENSMUSG00185002505	protein coding gene	Chr12:80829429-80896484 (+)
FVB/NJ	ENSMUSG00205026873	protein coding gene	Chr12:78640990-78708050 (+)
JF1/MsJ	ENSUMUG00000046166	protein coding gene	Chr12:84814677-84881657 (+)
LP/J	ENSMUSG00230043114	protein coding gene	Chr12:87891601-87958651 (+)
NOD/ShiLtJ	ENSMUSG00190037526	protein coding gene	Chr12:78029193-78096242 (+)
NZO/HlLtJ	ENSMUSG00225048807	protein coding gene	Chr12:89928739-89995786 (+)
PWK/PhJ	ENSLUMG00010025808	protein coding gene	Chr12:78834404-78901448 (+)
SPRET/EiJ	ENSMSPG00010017115	protein coding gene	Chr12:80651457-80724672 (+)
WSB/EiJ	ENSIUOG00005036406	protein coding gene	Chr12:78683208-78750407 (+)

Human Ortholog

FLVCR2, FLVCR choline and putative heme transporter 2

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

FLVCR2, FLVCR choline and putative heme transporter 2
Synonyms

C14orf58, CCT, EPV, FLVCRL14q, MFSD7C, PVHH, SLC49A2, SLC49A5
Links

HGNC:20105

NCBI Gene ID: 55640

UniProt: Q9UPI3
Chr Location

14q24.3; chr14:75578594-75663214 (+) GRCh38

MGI Vertebrate Homology

Flvcr2 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: FLVCR2
Gene Tree

Flvcr2

Diseases

1 with Flvcr2 mouse models; 1 with human FLVCR2 associations

Human Disease

Mouse Models

proliferative vasculopathy and hydranencephaly-hydrocephaly syndrome

IDs

View 1 model

Click on a disease name to see all genes associated with that disease.

Mutations/Alleles

1 with disease annotations

References

1 with disease annotations

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Phenotype Summary

34 phenotypes from 3 alleles in 2 genetic backgrounds
20 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

13
Chemically induced (other)

1
Endonuclease-mediated

3
Gene trapped

2
Targeted

7
Genomic Mutations

1 involving Flvcr2
Incidental Mutations

APF
Find Mice (IMSR)

24 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a null allele exhibit neonatal lethality, cyanosis, and impaired brain vasculature development.

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All GO Annotations

57
GO References

13

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

604
Tissues

7
cDNA Data

32
Literature Summary

5

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase flvcr2

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All Sequences

39
RefSeq

4
UniProt

3
CCDS

CCDS26062.1

Ensembl

ENSMUSG00000034258 (Evidence)
NCBI Gene

217721

			Length	Strain/Species	Flank
genomic	217721	NCBI Gene Model \| MGI Sequence Detail	67047	C57BL/6J	± kb
transcript	NM_145447	RefSeq \| MGI Sequence Detail	3435	C57BL/6
polypeptide	Q91X85	UniProt \| EBI \| MGI Sequence Detail	551	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000007567 choline/ethanolamine transporter FLVCR2

(term hierarchy)
PDB

8VZN, 8VZO
InterPro Domains

IPR049680 Choline/ethanolamine transporter FLVCR1-2/SLC49-like

IPR011701 Major facilitator superfamily

IPR020846 Major facilitator superfamily domain

IPR036259 MFS transporter superfamily

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All nucleic 32

cDNA 32

Microarray probesets 3

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MGI:5906163

Summaries

All 53

Developmental Gene Expression 5

Diseases 1

Gene Ontology 13

Phenotypes 20
Earliest

J:82808 Strausberg RL, et al., Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903
Latest

J:389753 Goncalves A, et al., FLVCR2 Regulation of Intracellular Heme Modulates Vascular Tip/Stalk Specification During Retinal Angiogenesis. Invest Ophthalmol Vis Sci. 2026 Jul 1;67(8):32

TSS for Flvcr2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr114429	Chr12:85793314-85793325 (+)	7 bp
Tssr114430	Chr12:85793326-85793346 (+)	23 bp
Tssr114431	Chr12:85793348-85793378 (+)	50 bp
Tssr114432	Chr12:85806285-85806311 (+)	12,985 bp
Tssr114433	Chr12:85821589-85821604 (+)	28,284 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/08/2026 MGI 6.24