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Fcgr4 Gene Detail
Summary
  • Symbol
    Fcgr4
  • Name
    Fc receptor, IgG, low affinity IV
  • Synonyms
    4833442P21Rik, CD16-2, FcgammaRIV, Fcgr3a
  • Feature Type
    protein coding gene
  • IDs
    MGI:2179523
    NCBI Gene: 246256
Location & Maps
more
  • Sequence Map
    Chr1:171018920-171029761 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      10842 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 1, 78.53 cM
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    FCGR3A, Fc fragment of IgG receptor IIIa
  • Vertebrate Orthologs
    8
  • Human Ortholog
    FCGR3A, Fc fragment of IgG receptor IIIa
    Orthology source: HomoloGene
  • Synonyms
    CD16, CD16A, FCG3, FCGR3, FCGRIII, FCR-10, FCRIII, FCRIIIA, IGFR3, IMD20
  • Links
    NCBI Gene ID: 2214
    neXtProt AC: NX_P08637

  • Chr Location
    1q23; chr1:161541759-161550623 (-)  GRCh38.p2

  • Human Ortholog
    FCGR3B, Fc fragment of IgG receptor IIIb
    Orthology source: HomoloGene
  • Synonyms
    CD16, CD16b, FCG3, FCGR3, FCR-10, FCRIII, FCRIIIb
  • Links
    NCBI Gene ID: 2215
    neXtProt AC: NX_O75015

  • Chr Location
    1q23; chr1:161623196-161631963 (-)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with human FCGR3A associations

Human Disease Mouse Models
       Immunodeficiency 20; IMD20   OMIM: 615707
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    8 phenotypes from 2 alleles in 1 genetic background
    1 phenotype from multigenic genotypes
    1 images
    23 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    11
  • Chemically induced (other)
    2
  • Gene trapped
    1
  • Not Specified
    1
  • Targeted
    5
  • Transgenic
    2
  • Genomic Mutations
    4 involving Fcgr4
  • Incidental Mutations
Mice homozygous for a knock-out allele exhibit decreased susceptibility to induced arthritis and nephrotoxic nephritis.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000022168 VEGA Gene Model | MGI Sequence Detail 10842 C57BL/6J ±  kb
transcript OTTMUST00000052638 VEGA | MGI Sequence Detail 1256 Not Applicable  
polypeptide OTTMUSP00000024985 VEGA | MGI Sequence Detail 249 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    145 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 6
    cDNA 6

    Microarray probesets 2
Other
Accession IDs
less
MGI:2443436
References
more
  • Summaries
    All 41
    Gene Ontology 2
    Phenotypes 23
  • Earliest
    J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
  • Latest
    J:225895 Ngiow SF, et al., A Threshold Level of Intratumor CD8+ T-cell PD1 Expression Dictates Therapeutic Response to Anti-PD1. Cancer Res. 2015 Sep 15;75(18):3800-11

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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Funding Information
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last database update
06/22/2016
MGI 6.04
The Jackson Laboratory