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Fcgr4 Gene Detail
Summary
  • Symbol
    Fcgr4
  • Name
    Fc receptor, IgG, low affinity IV
  • Synonyms
    4833442P21Rik, CD16-2, FcgammaRIV, Fcgr3a
  • Feature Type
    protein coding gene
  • IDs
    MGI:2179523
    NCBI Gene: 246256
  • Alliance
  • Transcription Start Sites
    16 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:170846495-170857330 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 1, 78.53 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    145 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2179523
protein coding gene Chr1:170846489-170857330 (+)
129S1/SvImJ MGP_129S1SvImJ_G0016739
protein coding gene Chr1:176772471-176783337 (+)
A/J MGP_AJ_G0016719
protein coding gene Chr1:169560700-169571617 (+)
AKR/J MGP_AKRJ_G0016685
protein coding gene Chr1:174655996-174666796 (+)
BALB/cJ MGP_BALBcJ_G0016680
protein coding gene Chr1:170037453-170048277 (+)
C3H/HeJ MGP_C3HHeJ_G0016503
protein coding gene Chr1:174894077-174905360 (+)
C57BL/6NJ MGP_C57BL6NJ_G0017141
protein coding gene Chr1:182623845-182634676 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0014850
protein coding gene Chr1:161278656-161288966 (+)
CAST/EiJ MGP_CASTEiJ_G0016084
protein coding gene Chr1:174526803-174540323 (+)
CBA/J MGP_CBAJ_G0016478
protein coding gene Chr1:189122459-189133674 (+)
DBA/2J MGP_DBA2J_G0016585
protein coding gene Chr1:168409938-168420997 (+)
FVB/NJ MGP_FVBNJ_G0016581
protein coding gene Chr1:166771177-166782483 (+)
LP/J MGP_LPJ_G0016656
protein coding gene Chr1:177892090-177903006 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0016608
protein coding gene Chr1:196417183-196428153 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0017178
protein coding gene Chr1:174539466-174550865 (+)
PWK/PhJ MGP_PWKPhJ_G0015870
protein coding gene Chr1:167652887-167663806 (+)
SPRET/EiJ MGP_SPRETEiJ_G0015654
protein coding gene Chr1:173293408-173307322 (+)
WSB/EiJ MGP_WSBEiJ_G0016146
protein coding gene Chr1:174661761-174672617 (+)



Homology
more
  • Human Ortholog
    FCGR3A, Fc gamma receptor IIIa
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    FCGR3A, Fc gamma receptor IIIa
  • Synonyms
    CD16, CD16A, CD16-II, FCG3, FCGR3, FCGRIII, FcGRIIIA, FCR-10, FCRIII, FCRIIIA, IGFR3, IMD20
  • Links
    NCBI Gene ID: 2214
    neXtProt AC: NX_P08637
    UniProt: P08637

  • Chr Location
    1q23.3; chr1:161541759-161550968 (-)  GRCh38

  • Human Ortholog
    FCGR3B, Fc gamma receptor IIIb
  • Synonyms
    CD16, CD16A, CD16b, CD16-I, FCG3, FCGR3, FCGR3A, FCR-10, FCRIII, FCRIIIb
  • Links
    NCBI Gene ID: 2215
    neXtProt AC: NX_O75015
    UniProt: O75015

  • Chr Location
    1q23.3; chr1:161623196-161631963 (-)  GRCh38

Human Diseases
more
  • Diseases
    25 with human FCGR3A associations

Human Disease Mouse Models
      
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Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    8 phenotypes from 2 alleles in 1 genetic background
    1 images
    48 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit decreased susceptibility to induced arthritis and nephrotoxic nephritis.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 246256 NCBI Gene Model | MGI Sequence Detail 10836 C57BL/6J ±  kb
    transcript NM_144559 RefSeq | MGI Sequence Detail 1250 ZRU/MplStud  
    polypeptide A0A0B4J1G0 UniProt | EBI | MGI Sequence Detail 249 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 8
      cDNA 7
      Primer pair 1

      Microarray probesets 2
    Other
    Accession IDs
    less
    MGI:2443436
    References
    more
    • Summaries
      All 88
      Developmental Gene Expression 2
      Gene Ontology 11
      Phenotypes 48
    • Earliest
      J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
    • Latest
      J:330538 Sahin M, et al., Antibody bivalency improves antiviral efficacy by inhibiting virion release independently of Fc gamma receptors. Cell Rep. 2022 Feb 1;38(5):110303

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    last database update
    03/12/2024
    MGI 6.23
    The Jackson Laboratory