About   Help   FAQ
Fcgr4
Gene Detail
Symbol

Name
ID
Fcgr4
Fc receptor, IgG, low affinity IV
MGI:2179523
Synonyms
4833442P21Rik, CD16-2, FcgammaRIV, Fcgr3a
Feature Type
protein coding gene
Genetic Map
Chromosome 1
78.53 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr1:171018920-171029761 bp, + strand
From VEGA annotation of GRCm38

  10842 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:477  Vertebrate Homology Class
2 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

Protein SuperFamily: Fc gamma receptor III
Gene Tree: Fcgr4

Human
homologs
Human Homolog FCGR3A, Fc fragment of IgG, low affinity IIIa, receptor (CD16a)
NCBI Gene ID 2214
neXtProt AC  NX_P08637
Human Synonyms  CD16, CD16A, FCG3, FCGR3, FCGRIII, FCR-10, FCRIII, FCRIIIA, IGFR3, IMD20
Human Chr (Location)  1q23; chr1:161541759-161550737 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human FCGR3A
Human Homolog FCGR3B, Fc fragment of IgG, low affinity IIIb, receptor (CD16b)
NCBI Gene ID 2215
neXtProt AC  NX_O75015
Human Synonyms  CD16, CD16b, FCG3, FCGR3, FCR-10, FCRIII, FCRIIIb
Human Chr (Location)  1q23; chr1:161623196-161631963 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(7) : Gene trapped(1) Not Specified(1) Targeted(5)
Genomic Mutations involving Fcgr4 (2)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele exhibit decreased susceptibility to induced arthritis and nephrotoxic nephritis.
 
Phenotype Images(1)
Interactions
Fcgr4 interacts with 75 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (7 annotations)
Process cellular response to lipopolysaccharide, NK T cell proliferation, ...
Component cell surface, external side of plasma membrane, ...
External Resources: FuncBase
Expression
cDNA source data(6)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(6) cDNA(6)
Microarray probesets(2)
Other database
links
VEGA Gene ModelOTTMUSG00000022168 (Evidence)
Ensembl Gene ModelENSMUSG00000059089 (Evidence)
Entrez Gene246256 (Evidence)
UniGene251254
DFCITC1585503
DoTSDT.97334973, DT.91595460
NIA Mouse Gene IndexU001076
Consensus CDS ProjectCCDS15476.1
International Mouse Knockout Project StatusFcgr4
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000022168 VEGA Gene Model | MGI Sequence Detail 10842 C57BL/6J ±  kb
transcript OTTMUST00000052638 VEGA | MGI Sequence Detail 1256 Not Applicable 
polypeptide OTTMUSP00000024985 VEGA | MGI Sequence Detail 249 Not Applicable 

For the selected sequences
All sequences(25) RefSeq(2) UniProt(6)
Polymorphisms
SNPs within 2kb(146 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR007110 Immunoglobulin-like domain
InterPro IPR013783 Immunoglobulin-like fold
InterPro IPR003599 Immunoglobulin subtype
References
(Earliest) J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
(Latest) J:212944 Zhang G, et al., Fcgamma receptor-mediated inflammation inhibits axon regeneration. PLoS One. 2014;9(2):e88703
All references(43)
Other
accession IDs
MGI:2443436

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
11/18/2014
MGI 5.20
The Jackson Laboratory