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Fcgr4
Gene Detail
 Symbol
Name
ID
Fcgr4
Fc receptor, IgG, low affinity IV
MGI:2179523
Synonyms 4833442P21Rik, CD16-2, FcgammaRIV, Fcgr3a
Feature Type protein coding gene
Genetic Map
Chromosome 1
78.53 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr1:171018920-171029761 bp, + strand
From VEGA annotation of GRCm38

  10842 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:477  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

Protein SuperFamily: Fc gamma receptor III
Gene Tree: Fcgr4

Human
homologs
Human Homolog FCGR3A, Fc fragment of IgG, low affinity IIIa, receptor (CD16a)
NCBI Gene ID 2214
neXtProt AC  NX_P08637
Human Synonyms  CD16, CD16A, FCG3, FCGR3, FCGRIII, FCR-10, FCRIII, FCRIIIA, IGFR3, IMD20
Human Chr (Location)  1q23; chr1:161541759-161550737 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human FCGR3A
Alleles
and
phenotypes
All alleles(5) : Targeted(4) Gene trapped(1)
 
Mice homozygous for a knock-out allele exhibit decreased susceptibility to induced arthritis and nephrotoxic nephritis.
 
Gene Ontology
(GO)
classifications
All GO classifications: (7 annotations)
Process cellular response to lipopolysaccharide, NK T cell proliferation, ...
Component cell surface, external side of plasma membrane, ...
External Resources: FuncBase
Expression
cDNA source data(6)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(6) cDNA(6)
Microarray probesets(2)
Other database
links
VEGA Gene ModelOTTMUSG00000022168 (Evidence)
Ensembl Gene ModelENSMUSG00000059089 (Evidence)
Entrez Gene246256 (Evidence)
UniGene251254
DFCITC1585503
DoTSDT.91595460, DT.97334973
Consensus CDS ProjectCCDS15476.1
International Mouse Knockout Project StatusFcgr4
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000022168 VEGA Gene Model | MGI Sequence Detail 10842 C57BL/6J ±  kb
transcript OTTMUST00000052638 VEGA | MGI Sequence Detail 1256 Not Applicable 
polypeptide OTTMUSP00000024985 VEGA | MGI Sequence Detail 249 Not Applicable 

For the selected sequences
All sequences(21) RefSeq(2) UniProt(3)
Polymorphisms SNPs within 2kb(146 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR007110 Immunoglobulin-like domain
InterPro IPR013783 Immunoglobulin-like fold
InterPro IPR003599 Immunoglobulin subtype
References (Earliest) J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
(Latest) J:206868 DiLillo DJ, et al., Broadly neutralizing hemagglutinin stalk-specific antibodies require FcgammaR interactions for protection against influenza virus in vivo. Nat Med. 2014 Feb;20(2):143-51
All references(42)
Other
accession IDs
MGI:2443436

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
04/08/2014
MGI 5.17
The Jackson Laboratory