Fcgr4
Gene Detail

Symbol Name ID

Fcgr4 Fc receptor, IgG, low affinity IV MGI:2179523

Synonyms

4833442P21Rik, CD16-2, FcgammaRIV, Fcgr3a

Feature Type

protein coding gene

Genetic Map

Chromosome 1

78.53 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr1:171018920-171029761 bp, + strand From VEGA annotation of GRCm38   10842 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:477  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

Protein SuperFamily: Fc gamma receptor III
Gene Tree: Fcgr4

Human homologs

Human Homolog		FCGR3A, Fc fragment of IgG, low affinity IIIa, receptor (CD16a)
NCBI Gene ID		2214
neXtProt AC		NX_P08637
Human Synonyms		CD16, CD16A, FCG3, FCGR3, FCGRIII, FCR-10, FCRIII, FCRIIIA, IGFR3
Human Chr (Location)		1q23; chr1:161511549-161520413 (-)  GRCh37.p10

Alleles and phenotypes

All alleles(4) : Targeted(3) Gene trapped(1)
 

Mice homozygous for a knock-out allele exhibit decreased susceptibility to induced arthritis and nephrotoxic nephritis.

 

Gene Ontology (GO) classifications

All GO classifications: (6 annotations)

Process	cellular response to lipopolysaccharide, NK T cell proliferation, ...
Component	cell surface, external side of plasma membrane, ...

External Resources: FuncBase

Expression

cDNA source data(6)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(6) cDNA(6)
Microarray probesets(2)

Other database links

VEGA Gene Model	OTTMUSG00000022168 (Evidence)
Ensembl Gene Model	ENSMUSG00000059089 (Evidence)
Entrez Gene	246256 (Evidence)
UniGene	251254
DFCI	TC1585503
DoTS	DT.91595460, DT.97334973
Consensus CDS Project	CCDS15476.1
International Mouse Knockout Project Status	Fcgr4

Sequences

Length	Strain/Species
genomic	OTTMUSG00000022168	VEGA Gene Model | MGI Sequence Detail	10842	C57BL/6J
transcript	OTTMUST00000052638	VEGA | MGI Sequence Detail	1256	Not Applicable
polypeptide	OTTMUSP00000024985	VEGA | MGI Sequence Detail	249	Not Applicable

All sequences(21) RefSeq(2) UniProt(3)

Polymorphisms

SNPs(80 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR007110	Immunoglobulin-like
InterPro	IPR013783	Immunoglobulin-like fold
InterPro	IPR003599	Immunoglobulin subtype

References

(Earliest) J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
(Latest) J:190859 Albanesi M, et al., Cutting Edge: FcgammaRIII (CD16) and FcgammaRI (CD64) Are Responsible for Anti-Glycoprotein 75 Monoclonal Antibody TA99 Therapy for Experimental Metastatic B16 Melanoma. J Immunol. 2012 Dec 15;189(12):5513-7
All references(39)

Other accession IDs

MGI:2443436