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Znrf1 Gene Detail
Summary
  • Symbol
    Znrf1
  • Name
    zinc and ring finger 1
  • Synonyms
    B830022L21Rik, nin283, Rnf42, Zrfp1
  • Feature Type
    protein coding gene
  • IDs
    MGI:2177308
    NCBI Gene: 170737
  • Gene Overview
    MyGene.info: ZNRF1
  • Alliance
  • Transcription Start Sites
    8 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:111536640-111626030 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 8, 57.98 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    459 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2177308
protein coding gene Chr8:111536097-111626030 (.)
129S1/SvImJ MGP_129S1SvImJ_G0034141
protein coding gene Chr8:114318435-114426563 (+)
A/J MGP_AJ_G0034121
protein coding gene Chr8:109676996-109769523 (+)
AKR/J MGP_AKRJ_G0034048
protein coding gene Chr8:112888021-112980523 (+)
BALB/cJ MGP_BALBcJ_G0034115
protein coding gene Chr8:109847281-109936664 (+)
C3H/HeJ MGP_C3HHeJ_G0033826
protein coding gene Chr8:113619014-113713081 (+)
C57BL/6NJ MGP_C57BL6NJ_G0034635
protein coding gene Chr8:118318812-118416484 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0031577
protein coding gene Chr8:102636813-102726262 (+)
CAST/EiJ MGP_CASTEiJ_G0033153
protein coding gene Chr8:113243936-113337133 (+)
CBA/J MGP_CBAJ_G0033799
protein coding gene Chr8:122375968-122480067 (+)
DBA/2J MGP_DBA2J_G0033955
protein coding gene Chr8:108952550-109042785 (+)
FVB/NJ MGP_FVBNJ_G0033898
protein coding gene Chr8:107928199-108022143 (+)
LP/J MGP_LPJ_G0034045
protein coding gene Chr8:114483722-114577311 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0033945
protein coding gene Chr8:125221459-125349468 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0034653
protein coding gene Chr8:112871783-112968479 (+)
PWK/PhJ MGP_PWKPhJ_G0032855
protein coding gene Chr8:108548014-108639638 (+)
SPRET/EiJ MGP_SPRETEiJ_G0032695
protein coding gene Chr8:111528081-111620421 (+)
WSB/EiJ MGP_WSBEiJ_G0033269
protein coding gene Chr8:113551671-113647661 (+)



Homology
more
  • Human Ortholog
    ZNRF1, zinc and ring finger 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    ZNRF1, zinc and ring finger 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    NIN283
  • Links
    NCBI Gene ID: 84937
    neXtProt AC: NX_Q8ND25
    UniProt: Q8ND25

  • Chr Location
    16q23.1; chr16:74999017-75110994 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 41858
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: ZNRF1
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 170737 NCBI Gene Model | MGI Sequence Detail 89391 C57BL/6J ±  kb
transcript NM_133206 RefSeq | MGI Sequence Detail 5252 C57BL/6  
polypeptide Q91V17 UniProt | EBI | MGI Sequence Detail 227 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 11
    cDNA 11

    Microarray probesets 5
Other
Accession IDs
less
MGI:1915360, MGI:2142443
References
more
  • Summaries
    All 34
    Developmental Gene Expression 3
    Gene Ontology 4
    Phenotypes 5
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:230742 Wakatsuki S, et al., Oxidative stress-dependent phosphorylation activates ZNRF1 to induce neuronal/axonal degeneration. J Cell Biol. 2015 Nov 23;211(4):881-96

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory