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Usp33 Gene Detail
Summary
  • Symbol
    Usp33
  • Name
    ubiquitin specific peptidase 33
  • Synonyms
    9830169D19Rik, Vdu1
  • Feature Type
    protein coding gene
  • IDs
    MGI:2159711
    NCBI Gene: 170822
  • Gene Overview
    MyGene.info: USP33
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:152346478-152393617 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 3, 77.15 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    228 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2159711
protein coding gene Chr3:152346478-152393617 (.)
129S1/SvImJ MGP_129S1SvImJ_G0027991
protein coding gene Chr3:156202541-156256976 (+)
A/J MGP_AJ_G0027950
protein coding gene Chr3:150533928-150582148 (+)
AKR/J MGP_AKRJ_G0027916
protein coding gene Chr3:154506352-154556618 (+)
BALB/cJ MGP_BALBcJ_G0027962
protein coding gene Chr3:150368377-150416207 (+)
C3H/HeJ MGP_C3HHeJ_G0027692
protein coding gene Chr3:154933516-154982418 (+)
C57BL/6NJ MGP_C57BL6NJ_G0028405
protein coding gene Chr3:161346976-161399467 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0025743
protein coding gene Chr3:145366661-145413694 (+)
CAST/EiJ MGP_CASTEiJ_G0027145
protein coding gene Chr3:155011444-155059444 (+)
CBA/J MGP_CBAJ_G0027667
protein coding gene Chr3:167136427-167190034 (+)
DBA/2J MGP_DBA2J_G0027807
protein coding gene Chr3:149647875-149695575 (+)
FVB/NJ MGP_FVBNJ_G0027774
protein coding gene Chr3:147013387-147062294 (+)
LP/J MGP_LPJ_G0027918
protein coding gene Chr3:157571914-157622373 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0027807
protein coding gene Chr3:175674832-175722803 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0028464
protein coding gene Chr3:154198333-154248646 (+)
PWK/PhJ MGP_PWKPhJ_G0026868
protein coding gene Chr3:149529824-149578064 (+)
SPRET/EiJ MGP_SPRETEiJ_G0026696
protein coding gene Chr3:152343745-152392253 (+)
WSB/EiJ MGP_WSBEiJ_G0027225
protein coding gene Chr3:155198404-155248486 (+)



Homology
more
  • Human Ortholog
    USP33, ubiquitin specific peptidase 33
  • Vertebrate Orthologs
    10
  • Human Ortholog
    USP33, ubiquitin specific peptidase 33
    Orthology source: HomoloGene, HGNC
  • Synonyms
    VDU1
  • Links
    NCBI Gene ID: 23032
    neXtProt AC: NX_Q8TEY7
    UniProt: Q8TEY7

  • Chr Location
    1p31.1; chr1:77695987-77759879 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 8996
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: USP33
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    6 phenotypes from 1 allele in 1 genetic background
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 170822 NCBI Gene Model | MGI Sequence Detail 47140 C57BL/6J ±  kb
    transcript NM_133247 RefSeq | MGI Sequence Detail 4209 C57BL/6  
    polypeptide Q8R5K2 UniProt | EBI | MGI Sequence Detail 909 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 175
      cDNA 175

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:2139571, MGI:2443996
    References
    more
    • Summaries
      All 40
      Developmental Gene Expression 2
      Gene Ontology 8
      Phenotypes 9
    • Earliest
      J:74628 Li Z, et al., Ubiquitination of a novel deubiquitinating enzyme requires direct binding to von Hippel-Lindau tumor suppressor protein. J Biol Chem. 2002 Feb 15;277(7):4656-62
    • Latest
      J:252045 Cubillos-Rojas M, et al., The HERC2 ubiquitin ligase is essential for embryonic development and regulates motor coordination. Oncotarget. 2016 Aug 30;7(35):56083-56106

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory