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Usp33 Gene Detail
Summary
  • Symbol
    Usp33
  • Name
    ubiquitin specific peptidase 33
  • Synonyms
    9830169D19Rik, Vdu1
  • Feature Type
    protein coding gene
  • IDs
    MGI:2159711
    NCBI Gene: 170822
  • Gene Overview
    MyGene.info: USP33
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr3:152346478-152393617 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      47140 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 3, 77.15 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    USP33, ubiquitin specific peptidase 33
  • Vertebrate Orthologs
    10
  • Human Ortholog
    USP33, ubiquitin specific peptidase 33
    Orthology source: HomoloGene, HGNC
  • Synonyms
    VDU1
  • Links
    NCBI Gene ID: 23032
    neXtProt AC: NX_Q8TEY7
    UniProt: Q8TEY7

  • Chr Location
    1p31.1; chr1:77695987-77759879 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 8996
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: USP33
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    6 phenotypes from 1 allele in 1 genetic background
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
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    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000027542 VEGA Gene Model | MGI Sequence Detail 47140 C57BL/6J ±  kb
    transcript OTTMUST00000068197 VEGA | MGI Sequence Detail 4183 Not Applicable  
    polypeptide OTTMUSP00000034416 VEGA | MGI Sequence Detail 909 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      228 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 174
      cDNA 174

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:2139571, MGI:2443996
    References
    more
    • Summaries
      All 38
      Developmental Gene Expression 2
      Gene Ontology 6
      Phenotypes 9
    • Earliest
      J:74628 Li Z, et al., Ubiquitination of a novel deubiquitinating enzyme requires direct binding to von Hippel-Lindau tumor suppressor protein. J Biol Chem. 2002 Feb 15;277(7):4656-62
    • Latest
      J:252045 Cubillos-Rojas M, et al., The HERC2 ubiquitin ligase is essential for embryonic development and regulates motor coordination. Oncotarget. 2016 Aug 30;7(35):56083-56106

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    06/12/2018
    MGI 6.12
    The Jackson Laboratory