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Usp33
Gene Detail
Symbol

Name
ID
Usp33
ubiquitin specific peptidase 33
MGI:2159711
Synonyms
9830169D19Rik, Vdu1
Feature Type
protein coding gene
Genetic Map
Chromosome 3
77.15 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr3:152346478-152393612 bp, + strand
From VEGA annotation of GRCm38

  47135 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:8996  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: USP33
Gene Tree: Usp33

Human
homologs
USP33, ubiquitin specific peptidase 33
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 23032
neXtProt AC: NX_Q8TEY7

Human Synonyms: VDU1

Human Chr (Location): 1p31.1; chr1:77695987-77759879 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(12) : Gene trapped(9) Targeted(3)
Incidental mutations (data from Mutagenetix , APF , CvDC )
Interactions
Usp33 interacts with 369 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (40 annotations)
Process axon guidance, cell migration, ...
Component autophagosome, cell body, ...
Function cysteine-type endopeptidase activity, cysteine-type peptidase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (1 records)
Data Summary: Results (11)    Tissues (10)    Images (13)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 11
cDNA source data(171)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase usp33 ; ZFIN usp33    NEW 
Molecular
reagents
All nucleic(176) cDNA(174) Other(2)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000027542 (Evidence)
Ensembl Gene Model ENSMUSG00000025437 (Evidence)
Entrez Gene 170822 (Evidence)
UniGene 258320
DFCI TC1597150, TC1597143, TC1576176, TC1597681, TC1614295, TC1773394, TC1636795
DoTS DT.101386231, DT.101268659, DT.101332438, DT.101176223, DT.101248177, DT.99858702, DT.87056710, DT.492257
NIA Mouse Gene Index U003992
EC 3.4.19.12
Consensus CDS Project CCDS17918.1, CCDS57261.1
International Mouse Phenotyping Consortium Status Usp33
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000027542 VEGA Gene Model | MGI Sequence Detail 47135 C57BL/6J ±  kb
transcript OTTMUST00000068197 VEGA | MGI Sequence Detail 3896 Not Applicable 
polypeptide OTTMUSP00000034416 VEGA | MGI Sequence Detail 909 Not Applicable 

For the selected sequences
All sequences(71) RefSeq(8) UniProt(3)
Polymorphisms
SNPs within 2kb(228 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001394 Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2
InterPro IPR018200 Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2, conserved site
InterPro IPR006615 Peptidase C19, ubiquitin-specific peptidase, DUSP domain
InterPro IPR013083 Zinc finger, RING/FYVE/PHD-type
InterPro IPR001607 Zinc finger, UBP-type
Protein Ontology PR:000017172 ubiquitin carboxyl-terminal hydrolase 33
References
(Earliest) J:74628 Li Z, et al., Ubiquitination of a novel deubiquitinating enzyme requires direct binding to von Hippel-Lindau tumor suppressor protein. J Biol Chem. 2002 Feb 15;277(7):4656-62
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(41)
Other
accession IDs
MGI:2139571, MGI:2443996

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory