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Usp33 Gene Detail
Summary
  • Symbol
    Usp33
  • Name
    ubiquitin specific peptidase 33
  • Synonyms
    9830169D19Rik, Vdu1
  • Feature Type
    protein coding gene
  • IDs
    MGI:2159711
    NCBI Gene: 170822
  • Alliance
    genome feature page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:152052115-152099254 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 3, 77.15 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1220 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2159711
 protein coding gene Chr3:152051797-152099254 (+)
129S1/SvImJ ENSMUSG00200002817
 protein coding gene Chr3:149030406-149066214 (+)
A/J ENSMUSG00195003057
 protein coding gene Chr3:149157497-149193325 (+)
AKR/J ENSMUSG00220000159
 protein coding gene Chr3:147557325-147593102 (+)
BALB/cJ ENSMUSG00180026438
 protein coding gene Chr3:149007609-149043437 (+)
C3H/HeJ ENSMUSG00175017991
 protein coding gene Chr3:148626074-148661905 (+)
C57BL/6NJ ENSMUSG00215016435
 protein coding gene Chr3:149261638-149297417 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0025743
 protein coding gene Chr3:145366661-145413694 (+)
CAST/EiJ ENSTCUG00005001187
 protein coding gene Chr3:149667483-149703116 (+)
CBA/J ENSMUSG00210004080
 protein coding gene Chr3:149267771-149303578 (+)
DBA/2J ENSMUSG00185023624
 protein coding gene Chr3:149887920-149923697 (+)
FVB/NJ ENSMUSG00205008769
 protein coding gene Chr3:148164081-148199860 (+)
JF1/MsJ ENSUMUG00000028002
 protein coding gene Chr3:148638836-148682178 (+)
LP/J ENSMUSG00230015030
 protein coding gene Chr3:151779655-151815465 (+)
NOD/ShiLtJ ENSMUSG00190004108
 protein coding gene Chr3:150242103-150277881 (+)
NZO/HlLtJ ENSMUSG00225004885
 protein coding gene Chr3:154282657-154318434 (+)
PWK/PhJ ENSLUMG00010001742
 protein coding gene Chr3:148578968-148614745 (+)
SPRET/EiJ ENSMSPG00010007369
 protein coding gene Chr3:149899988-149947669 (+)
WSB/EiJ ENSIUOG00005014611
 protein coding gene Chr3:149370046-149405823 (+)



Homology
more
  • Human Ortholog
    USP33, ubiquitin specific peptidase 33
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    USP33, ubiquitin specific peptidase 33
  • Synonyms
    VDU1
  • Links
    NCBI Gene ID: 23032
    UniProt: Q8TEY7

  • Chr Location
    1p31.1; chr1:77694725-77759884 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    6 phenotypes from 1 allele in 1 genetic background
    14 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    56
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    614
  • Tissues
    13
  • cDNA Data
    172
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000025437 Ensembl Gene Model | MGI Sequence Detail 47140 C57BL/6J ±  kb
    transcript ENSMUST00000197748 Ensembl | MGI Sequence Detail 4183 Not Applicable  
    polypeptide ENSMUSP00000142708 Ensembl | MGI Sequence Detail 909 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 175
      cDNA 175
      Antibodies 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:2139571, MGI:2443996
    References
    more
    • Summaries
      All 50
      Developmental Gene Expression 2
      Gene Ontology 10
      Phenotypes 14
    • Earliest
      J:74628 Li Z, et al., Ubiquitination of a novel deubiquitinating enzyme requires direct binding to von Hippel-Lindau tumor suppressor protein. J Biol Chem. 2002 Feb 15;277(7):4656-62
    • Latest
      J:373048 Zhu Y, et al., USP33 Regulates DNA Damage Response and Carcinogenesis Through Deubiquitylating and Stabilising p53. Cell Prolif. 2025 May;58(5):e13793
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/15/2026
    MGI 6.29     		The Jackson Laboratory