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Havcr2
Gene Detail
Symbol

Name
ID
Havcr2
hepatitis A virus cellular receptor 2
MGI:2159682
Synonyms
Tim3, TIM-3, Timd3
Feature Type
protein coding gene
Genetic Map
Chromosome 11
27.90 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr11:46454935-46481255 bp, + strand
From VEGA annotation of GRCm38

  26321 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:129541  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog

HCOP human homology predictions: HAVCR2
Gene Tree: Havcr2

Human
homologs
HAVCR2, hepatitis A virus cellular receptor 2
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 84868
neXtProt AC: NX_Q8TDQ0

Human Synonyms: CD366, HAVcr-2, KIM-3, Tim-3, TIM3, TIMD3, TIMD-3

Human Chr (Location): 5q33.3; chr5:157085832-157109237 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Targeted(5)
Incidental mutations (data from APF , CvDC )
 
Mice homozygous for a knock-out allele exhibit normal thymic development and show no evidence of autoimmunity or lymphoproliferation. Mice homozygous for a different targeted allele exhibit improved survival following influenza infection.
 
Interactions
Havcr2 interacts with 245 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (10 annotations)
Process maternal process involved in female pregnancy, natural killer cell tolerance induction, ...
Component cell surface, extracellular exosome, ...
Function protein binding
External Resources: FuncBase
Expression
Literature Summary: (4 records)
Data Summary: Results (6)    Tissues (2)    Images (2)    Tissue x Stage Matrix (view)
Assay TypeResults
RT-PCR 6
cDNA source data(7)
Other mouse links: GEO   Expression Atlas
Molecular
reagents
All nucleic(9) cDNA(7) Primer pair(2)
Microarray probesets(2)
Other database
links
VEGA Gene Model OTTMUSG00000005503 (Evidence)
Ensembl Gene Model ENSMUSG00000020399 (Evidence)
Entrez Gene 171285 (Evidence)
UniGene 72168
DFCI TC1587876
DoTS DT.99852095, DT.99852094
PDB 2OYP, 3KAA
Consensus CDS Project CCDS36135.1
International Mouse Phenotyping Consortium Status Havcr2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000005503 VEGA Gene Model | MGI Sequence Detail 26321 C57BL/6J ±  kb
transcript OTTMUST00000012247 VEGA | MGI Sequence Detail 2721 Not Applicable 
polypeptide OTTMUSP00000005654 VEGA | MGI Sequence Detail 281 Not Applicable 

For the selected sequences
All sequences(28) RefSeq(4) UniProt(3)
Polymorphisms
SNPs within 2kb(143 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR007110 Immunoglobulin-like domain
InterPro IPR013783 Immunoglobulin-like fold
InterPro IPR003599 Immunoglobulin subtype
InterPro IPR013106 Immunoglobulin V-set
Protein Ontology PR:000008454 hepatitis A virus cellular receptor 2
References
(Earliest) J:72894 McIntire JJ, et al., Identification of Tapr (an airway hyperreactivity regulatory locus) and the linked Tim gene family. Nat Immunol. 2001 Dec;2(12):1109-16
(Latest) J:215719 Syrjanen R, et al., TIM-family molecules in embryonic hematopoiesis: fetal liver TIM-4(lo) cells have myeloid potential. Exp Hematol. 2014 Mar;42(3):230-40
All references(44)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/30/2015
MGI 5.22
The Jackson Laboratory