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Havcr2
Gene Detail
Symbol

Name
ID
Havcr2
hepatitis A virus cellular receptor 2
MGI:2159682
Synonyms
Tim3, TIM-3, Timd3
Feature Type
protein coding gene
Genetic Map
Chromosome 11
27.90 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr11:46454935-46481255 bp, + strand
From VEGA annotation of GRCm38

  26321 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:129541  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog

Gene Tree: Havcr2

Human
homologs
Human Homolog HAVCR2, hepatitis A virus cellular receptor 2
NCBI Gene ID 84868
neXtProt AC  NX_Q8TDQ0
Human Synonyms  HAVcr-2, KIM-3, Tim-3, TIM3, TIMD3, TIMD-3
Human Chr (Location)  5q33.3; chr5:157085832-157109237 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Targeted(4)
Incidental mutations (data from APF )
 
Mice homozygous for a knock-out allele exhibit normal thymic development and show no evidence of autoimmunity or lymphoproliferation. Mice homozygous for a different targeted allele exhibit improved survival following influenza infection.
 
Interactions
Havcr2 interacts with 245 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (4 annotations)
Component extracellular vesicular exosome, integral component of membrane, ...
Function protein binding
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (6)    Tissues (2)    Images (2)    Tissue x Stage Matrix (view)
Assay TypeResults
RT-PCR 6
cDNA source data(7)
External Resources: GEO   Expression Atlas
Molecular
reagents
All nucleic(9) cDNA(7) Primer pair(2)
Microarray probesets(2)
Other database
links
VEGA Gene ModelOTTMUSG00000005503 (Evidence)
Ensembl Gene ModelENSMUSG00000020399 (Evidence)
Entrez Gene171285 (Evidence)
UniGene72168
DFCITC1587876
DoTSDT.99852094, DT.99852095
PDB2OYP, 3KAA
Consensus CDS ProjectCCDS36135.1
International Mouse Knockout Project StatusHavcr2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000005503 VEGA Gene Model | MGI Sequence Detail 26321 C57BL/6J ±  kb
transcript OTTMUST00000012247 VEGA | MGI Sequence Detail 2721 Not Applicable 
polypeptide OTTMUSP00000005654 VEGA | MGI Sequence Detail 281 Not Applicable 

For the selected sequences
All sequences(28) RefSeq(4) UniProt(3)
Polymorphisms
SNPs within 2kb(143 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR007110 Immunoglobulin-like domain
InterPro IPR013783 Immunoglobulin-like fold
InterPro IPR003599 Immunoglobulin subtype
InterPro IPR013106 Immunoglobulin V-set
Protein Ontology PR:000008454 hepatitis A virus cellular receptor 2
References
(Earliest) J:72894 McIntire JJ, et al., Identification of Tapr (an airway hyperreactivity regulatory locus) and the linked Tim gene family. Nat Immunol. 2001 Dec;2(12):1109-16
(Latest) J:202569 Lee SY, et al., The influence of T cell Ig mucin-3 signaling on central nervous system autoimmune disease is determined by the effector function of the pathogenic T cells. J Immunol. 2013 May 15;190(10):4991-9
All references(41)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
10/08/2014
MGI 5.20
The Jackson Laboratory