Slc45a2
Gene Detail

Symbol Name ID

Slc45a2 solute carrier family 45, member 2 MGI:2153040

Synonyms

Aim1, Aim-1, blanc-sale, bls, Dbr, dominant brown, Matp

Feature Type

protein coding gene

Genetic Map

Chromosome 15

5.40 cM
Detailed Genetic Map ± 1 cM


Mapping data(31)

Sequence Map

Chr15:11000721-11029233 bp, + strand From VEGA annotation of GRCm38   28513 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Mammalian homology

human; rat; cattle; chimpanzee; dog, domestic    (Mammalian Orthology)
Comparative Map (Mouse/Human Slc45a2 ± 2 cM)

Gene Tree: Slc45a2

Human ortholog

SLC45A2 solute carrier family 45, member 2 NCBI Gene ID 51151
Human Synonyms: 1A1, AIM1, MATP, SHEP5
Human Chr5:33944721-33984780 bp, - strand Reference GRCh37.p2 Primary Assembly
Human Diseases Associated with Human SLC45A2 (1)

Alleles and phenotypes

All alleles(19) : Targeted(3) Spontaneous(7) Chemically induced(9)
 

Homozygotes for spontaneous mutations exhibit varied degrees of hypopigmentation of the eyes, skin, and hair, especially the underfur. Eyes are very light at birth but darken with age.

 
Human Diseases Modeled Using Mouse Slc45a2 (1)    Alleles Annotated to Human Diseases(6)    Phenotype Images(1)

Gene Ontology (GO) classifications

All GO classifications: (6 annotations)

Process	developmental pigmentation, melanin biosynthetic process, ...
Component	integral to membrane, membrane

External Resources: FuncBase

Expression

Literature Summary: (4 records)
Data Summary: Results (98)    Tissues (15)    Images (53)
Theiler Stages: 15, 17, 19, 21, 23

Assay Type	Results
RNA in situ	98

cDNA source data(9)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(11) cDNA(9) Primer pair(1) Other(1)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000026270 (Evidence)
Ensembl Gene Model	ENSMUSG00000022243 (Evidence)
Entrez Gene	22293 (Evidence)
UniGene	138278
DFCI	TC1577579
DoTS	DT.97399037
NIA Mouse Gene Index	U016081
Consensus CDS Project	CCDS27382.1
International Mouse Knockout Project Status	Slc45a2

Sequences

Length	Strain/Species
genomic	OTTMUSG00000026270	VEGA Gene Model | MGI Sequence Detail	28513	C57BL/6J
transcript	OTTMUST00000064964	VEGA | MGI Sequence Detail	2983	Not Applicable
polypeptide	OTTMUSP00000032314	VEGA | MGI Sequence Detail	459	Not Applicable

All sequences(35) RefSeq(2) UniProt(4)

Polymorphisms

SNPs(172 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR016196	Major facilitator superfamily domain, general substrate transporter
Protein Ontology	PR:000015149	membrane-associated transporter protein

References

(Earliest) J:13420 Dickie MM, Underwhite. Mouse News Lett. 1964;30:30
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(73)

Other accession IDs

MGD-MRK-15377, MGD-MRK-1579, MGD-MRK-8804, MGI:98920