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Slc45a2
Gene Detail
 Symbol
Name
ID
Slc45a2
solute carrier family 45, member 2
MGI:2153040
Synonyms Aim1, Aim-1, blanc-sale, bls, Dbr, dominant brown, Matp, Oca4
Feature Type protein coding gene
Genetic Map
Chromosome 15
5.40 cM
Detailed Genetic Map ± 1 cM


Mapping data(31)
Sequence Map
Chr15:11000721-11029233 bp, + strand
From VEGA annotation of GRCm38

  28513 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:9412  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Slc45a2

Human
homologs
Human Homolog SLC45A2, solute carrier family 45, member 2
NCBI Gene ID 51151
neXtProt AC  NX_Q9UMX9
Human Synonyms  1A1, AIM1, MATP, OCA4, SHEP5
Human Chr (Location)  5p13.2; chr5:33944616-33984675 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human SLC45A2
Alleles
and
phenotypes
All alleles(20) : Targeted(3) Spontaneous(7) Chemically induced(10)
 
Homozygotes for spontaneous mutations exhibit varied degrees of hypopigmentation of the eyes, skin, and hair, especially the underfur. Eyes are very light at birth but darken with age.
 
Human Diseases Modeled Using Mouse Slc45a2 (1)    Alleles Annotated to Human Diseases(6)    Phenotype Images(1)
Gene Ontology
(GO)
classifications
All GO classifications: (6 annotations)
Process developmental pigmentation, melanin biosynthetic process, ...
Component integral component of membrane, membrane
External Resources: FuncBase
Expression
Literature Summary: (4 records)
Data Summary: Results (98)    Tissues (15)    Images (53)
Theiler Stages: 15, 17, 19, 21, 23
Assay TypeResults
RNA in situ 98
cDNA source data(9)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(11) cDNA(9) Primer pair(1) Other(1)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000026270 (Evidence)
Ensembl Gene ModelENSMUSG00000022243 (Evidence)
Entrez Gene22293 (Evidence)
UniGene138278
DFCITC1577579
DoTSDT.97399037
NIA Mouse Gene IndexU016081
Consensus CDS ProjectCCDS27382.1
International Mouse Knockout Project StatusSlc45a2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000026270 VEGA Gene Model | MGI Sequence Detail 28513 C57BL/6J ±  kb
transcript OTTMUST00000064964 VEGA | MGI Sequence Detail 2983 Not Applicable 
polypeptide OTTMUSP00000032314 VEGA | MGI Sequence Detail 459 Not Applicable 

For the selected sequences
All sequences(37) RefSeq(4) UniProt(4)
Polymorphisms SNPs within 2kb(271 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR016196 Major facilitator superfamily domain, general substrate transporter
Protein Ontology PR:000015149 membrane-associated transporter protein
References (Earliest) J:13420 Dickie MM, Underwhite. Mouse News Lett. 1964;30:30
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(74)
Other
accession IDs
MGD-MRK-15377, MGD-MRK-1579, MGD-MRK-8804, MGI:98920

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
04/08/2014
MGI 5.17
The Jackson Laboratory