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Lrp1b
Gene Detail
Symbol

Name
ID
Lrp1b
low density lipoprotein-related protein 1B (deleted in tumors)
MGI:2151136
Synonyms
9630004P12Rik
Feature Type
protein coding gene
Genetic Map
Chromosome 2
24.51 cM, cytoband B
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr2:40595248-42653598 bp, - strand
From VEGA annotation of GRCm38

  2058351 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:56810  Vertebrate Homology Class
1 human; 1 mouse; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: LDL receptor-related protein
Gene Tree: Lrp1b

Human
homologs
Human Homolog LRP1B, low density lipoprotein receptor-related protein 1B
NCBI Gene ID 53353
neXtProt AC  NX_Q9NZR2
Human Synonyms  LRPDIT, LRP-DIT
Human Chr (Location)  2q21.2; chr2:140231427-142131701 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(9) : Gene trapped(4) Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null mice appear normal, are fertile, have normal brain histology and function, normal plasma cholesterol and fasting triglycerides, and do not develop tumors.
 
Interactions
Lrp1b interacts with 345 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (9 annotations)
Process endocytosis, receptor-mediated endocytosis
Component integral component of membrane, membrane, ...
Function calcium ion binding, low-density lipoprotein receptor activity, ...
External Resources: FuncBase
Expression
Literature Summary: (5 records)
Data Summary: Results (42)    Tissues (32)    Images (5)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 27
RT-PCR 15
cDNA source data(18)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(21) cDNA(20) Primer pair(1)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000012311 (Evidence)
Ensembl Gene ModelENSMUSG00000049252 (Evidence)
Entrez Gene94217 (Evidence)
UniGene441398
DFCITC1612543, TC1603854, TC1591099, TC1587258, TC1712030, TC1634785
DoTSDT.40155434, DT.101707183, DT.91333345, DT.97375675, DT.91350996, DT.91335244
NIA Mouse Gene IndexU022581
International Mouse Knockout Project StatusLrp1b
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000012311 VEGA Gene Model | MGI Sequence Detail 2058351 C57BL/6J ±  kb
transcript OTTMUST00000029305 VEGA | MGI Sequence Detail 16268 Not Applicable 
polypeptide OTTMUSP00000013225 VEGA | MGI Sequence Detail 4630 Not Applicable 

For the selected sequences
All sequences(71) RefSeq(14) UniProt(12)
Polymorphisms
SNPs within 2kb(23586 from dbSNP Build 137)    SNPs within 2kb including multiple locations(23614)
Protein-related
information
ResourceIDDescription
InterPro IPR026823 Complement Clr-like EGF domain
InterPro IPR001881 EGF-like calcium-binding
InterPro IPR018097 EGF-like calcium-binding, conserved site
InterPro IPR013032 EGF-like, conserved site
InterPro IPR000152 EGF-type aspartate/asparagine hydroxylation site
InterPro IPR000742 Epidermal growth factor-like domain
InterPro IPR009030 Insulin-like growth factor binding protein, N-terminal
InterPro IPR000033 LDLR class B repeat
InterPro IPR023415 Low-density lipoprotein (LDL) receptor class A, conserved site
InterPro IPR002172 Low-density lipoprotein (LDL) receptor class A repeat
InterPro IPR011042 Six-bladed beta-propeller, TolB-like
Protein Ontology PR:000009920 low-density lipoprotein receptor-related protein 1B
References
(Earliest) J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
(Latest) J:214694 Kur E, et al., LRP2 mediates folate uptake in the developing neural tube. J Cell Sci. 2014 May 15;127(Pt 10):2261-8
All references(37)
Other
accession IDs
MGI:2445076

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/09/2014
MGI 5.20
The Jackson Laboratory