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Tnfrsf21
Gene Detail
 Symbol
Name
ID
Tnfrsf21
tumor necrosis factor receptor superfamily, member 21
MGI:2151075
Synonyms Death receptor 6, DR6, TR7
Feature Type protein coding gene
Genetic Map
Chromosome 17
19.69 cM, cytoband C
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr17:43016555-43089188 bp, + strand
From NCBI annotation of GRCm38

  72634 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:8696  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Tnfrsf21

Human
homologs
Human Homolog TNFRSF21, tumor necrosis factor receptor superfamily, member 21
NCBI Gene ID 27242
neXtProt AC  NX_O75509
Human Synonyms  BM-018, CD358, DR6
Human Chr (Location)  6p21.1; chr6:47231527-47309947 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(13) : Gene trapped(8) Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele exhibit impaired T cell differentiation and an enhanced Th2 response. Mice homozygous for a different knock-out allele show increased CD4+ T cell proliferation and Th2 cytokine production, and enhanced B cell proliferation, survival, and humoral responses.
 
Interactions
Tnfrsf21 interacts with 267 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (24 annotations)
Process adaptive immune response, apoptotic process, ...
Component axon, integral component of membrane, ...
External Resources: FuncBase
Expression
Literature Summary: (4 records)
Data Summary: Results (263)    Tissues (44)    Images (24)
Theiler Stages: 23
Assay TypeResults
RNA in situ 263
cDNA source data(79)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(80) cDNA(80)
Microarray probesets(4)
Other database
links
Ensembl Gene ModelENSMUSG00000023915 (Evidence)
Entrez Gene94185 (Evidence)
UniGene200792
DFCITC1575993
DoTSDT.530855, DT.94345012, DT.97367415
NIA Mouse Gene IndexU018002
Consensus CDS ProjectCCDS28794.1
International Mouse Knockout Project StatusTnfrsf21
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 94185 NCBI Gene Model | MGI Sequence Detail 72634 C57BL/6J ±  kb
transcript NM_178589 RefSeq | MGI Sequence Detail 3626 C57BL/6 
polypeptide Q9EPU5 UniProt | EBI | MGI Sequence Detail 655 Not Applicable 

For the selected sequences
All sequences(25) RefSeq(2) UniProt(3)
Polymorphisms SNPs within 2kb(887 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000488 Death domain
InterPro IPR011029 Death-like domain
InterPro IPR001368 TNFR/NGFR cysteine-rich region
InterPro IPR022330 Tumour necrosis factor receptor 21
Protein Ontology PR:000016484 tumor necrosis factor receptor superfamily member 21
Graphical View of Protein Domain Structure
References (Earliest) J:70594 Liu J, et al., Enhanced CD4+ T cell proliferation and Th2 cytokine production in DR6-deficient mice. Immunity. 2001 Jul;15(1):23-34
(Latest) J:211049 Olsen O, et al., Genetic analysis reveals that amyloid precursor protein and death receptor 6 function in the same pathway to control axonal pruning independent of beta-secretase. J Neurosci. 2014 May 7;34(19):6438-47
All references(46)
Other
accession IDs
MGI:2146783, MGI:2147154

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory