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Tnfrsf21 Gene Detail
Summary
  • Symbol
    Tnfrsf21
  • Name
    tumor necrosis factor receptor superfamily, member 21
  • Synonyms
    Death receptor 6, DR6, TR7
  • Feature Type
    protein coding gene
  • IDs
    MGI:2151075
    NCBI Gene: 94185
  • Gene Overview
    MyGene.info: TNFRSF21
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr17:43016555-43089188 bp, + strand
  • From NCBI annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      72634 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 17, 19.69 cM, cytoband C
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    TNFRSF21, TNF receptor superfamily member 21
  • Vertebrate Orthologs
    9
  • Human Ortholog
    TNFRSF21, TNF receptor superfamily member 21
    Orthology source: HomoloGene, HGNC
  • Synonyms
    BM-018, CD358, DR6
  • Links
    NCBI Gene ID: 27242
    neXtProt AC: NX_O75509
    UniProt: O75509

  • Chr Location
    6p12.3; chr6:47231527-47309976 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    29 phenotypes from 4 alleles in 5 genetic backgrounds
    17 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit impaired T cell differentiation and an enhanced Th2 response. Mice homozygous for a different knock-out allele show increased CD4+ T cell proliferation and Th2 cytokine production, and enhanced B cell proliferation, survival, and humoral responses.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 94185 NCBI Gene Model | MGI Sequence Detail 72634 C57BL/6J ±  kb
    transcript NM_178589 RefSeq | MGI Sequence Detail 3626 C57BL/6  
    polypeptide Q9EPU5 UniProt | EBI | MGI Sequence Detail 655 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      867 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 81
      cDNA 81

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:2146783, MGI:2147154
    References
    more
    • Summaries
      All 49
      Developmental Gene Expression 4
      Gene Ontology 10
      Phenotypes 17
    • Earliest
      J:70594 Liu J, et al., Enhanced CD4+ T cell proliferation and Th2 cytokine production in DR6-deficient mice. Immunity. 2001 Jul;15(1):23-34
    • Latest
      J:261118 Colombo A, et al., Non-cell-autonomous function of DR6 in Schwann cell proliferation. EMBO J. 2018 Apr 3;37(7)

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    10/09/2018
    MGI 6.12
    The Jackson Laboratory