Sequence Detail

ID/Version

Q9EPU5 Q91XH9 Q3UYG3 Q91W77 Q543Y9 (UniProt | EBI)

Last sequence update: 2002-05-27
Last annotation update: 2024-01-24

Sequence description from provider

RecName: Full=Tumor necrosis factor receptor superfamily member 21;AltName: Full=Death receptor 6;AltName: CD_antigen=CD358;Flags: Precursor;

Provider

SWISS-PROT

Sequence

Polypeptide 655 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Tnfrsf21	tumor necrosis factor receptor superfamily, member 21	29	99	3	15

Sequence references in MGI

J:70594 Liu J, et al., Enhanced CD4+ T cell proliferation and Th2 cytokine production in DR6-deficient mice. Immunity. 2001 Jul;15(1):23-34
J:72761 Zhao H, et al., Impaired c-Jun Amino Terminal Kinase Activity and T Cell Differentiation in Death Receptor 6-deficient Mice. J Exp Med. 2001 Nov 19;194(10):1441-8
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:109341 Schmidt CS, et al., Enhanced B cell expansion, survival, and humoral responses by targeting death receptor 6. J Exp Med. 2003 Jan 6;197(1):51-62
J:146602 Nikolaev A, et al., APP binds DR6 to trigger axon pruning and neuron death via distinct caspases. (RETRACTION Nature https://doi.org/10.1038/nature07767). Nature. 2009 Feb 19;457(7232):981-9
J:205651 Mi S, et al., Death receptor 6 negatively regulates oligodendrocyte survival, maturation and myelination. Nat Med. 2011 Jul;17(7):816-21
J:205745 Hu Y, et al., A DR6/p75(NTR) complex is responsible for beta-amyloid-induced cortical neuron death. Cell Death Dis. 2013;4:e579
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89