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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Tnfrsf21
tumor necrosis factor receptor superfamily, member 21
MGI:2151075
29 phenotypes from 4 alleles in 5 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Tnfrsf21tm1Arte/Tnfrsf21tm1Arte
involves: C57BL/6NTac 		abnormal myelination J:205651
abnormal oligodendrocyte apoptosis J:205651
increased oligodendrocyte number J:205651
Tnfrsf21tm1Ddy/Tnfrsf21tm1Ddy
involves: 129S1/Sv * 129X1/SvJ 		abnormal T-helper 1 physiology J:70594
abnormal T-helper 2 physiology J:70594
increased B cell proliferation J:109341
increased IgG1 level J:109341
increased IgG2a level J:109341
increased IgG2b level J:109341
increased IgG3 level J:109341
increased IgM level J:109341
increased interleukin-4 secretion J:70594
increased interleukin-5 secretion J:70594
increased interleukin-10 secretion J:70594
increased interleukin-13 secretion J:70594
increased spleen germinal center size J:109341
increased T cell proliferation J:70594
Tnfrsf21tm1Vmd/Tnfrsf21tm1Vmd
involves: C57BL/6 		abnormal cell-mediated immunity J:72761
abnormal enzyme/coenzyme activity J:72761
abnormal T-helper 2 physiology J:72761
normal immune system phenotype J:72761
increased CD4-positive, alpha-beta T cell number J:72761
increased CD8-positive, alpha-beta T cell number J:72761
increased IgE level J:72761
increased IgG1 level J:72761
increased IgG2a level J:72761
increased IgM level J:72761
increased interferon-gamma secretion J:72761
increased interleukin-2 secretion J:72761
increased interleukin-4 secretion J:72761
increased T cell number J:72761
increased T cell proliferation J:72761
Tnfrsf21tm1Vmd/Tnfrsf21tm1Vmd
Not Specified 		abnormal brain vasculature morphology J:181470
impaired blood-brain barrier function J:181470
intracranial hemorrhage J:181470
Tnfrsf21tm2Gne/Tnfrsf21tm2Gne
Tg(Tek-cre)1Ywa/0
involves: C57BL/6 * SJL 		abnormal brain vasculature morphology J:181470
intracranial hemorrhage J:181470
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/23/2024
MGI 6.23 		The Jackson Laboratory