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Kiss1r Gene Detail
Summary
  • Symbol
    Kiss1r
  • Name
    KISS1 receptor
  • Synonyms
    Gpr54
  • Feature Type
    protein coding gene
  • IDs
    MGI:2148793
    NCBI Gene: 114229
  • Gene Overview
    MyGene.info: KISS1R
Location & Maps
more
  • Sequence Map
    Chr10:79916971-79922273 bp, + strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      5303 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 10, 39.72 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    KISS1R, KISS1 receptor
  • Vertebrate Orthologs
    9
  • Human Ortholog
    KISS1R, KISS1 receptor
    Orthology source: HomoloGene, HGNC
  • Synonyms
    AXOR12, CPPB1, GPR54, HH8, HOT7T175, KISS-1R
  • Links
    NCBI Gene ID: 84634
    neXtProt AC: NX_Q969F8

  • Chr Location
    19p13.3; chr19:917342-921015 (+)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with Kiss1r mouse models; 2 with human KISS1R associations

Human Disease Mouse Models
       Hypogonadotropic Hypogonadism 8 with or without Anosmia; HH8   OMIM: 614837 View 4 models
       Precocious Puberty, Central, 1; CPPB1   OMIM: 176400
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    4 with disease annotations
  • References
    5 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    116 phenotypes from 10 alleles in 9 genetic backgrounds
    4 phenotypes from multigenic genotypes
    2 images
    49 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    12
  • Chemically induced (other)
    1
  • Gene trapped
    1
  • Targeted
    9
  • Transgenic
    1
  • Genomic Mutations
    1 involving Kiss1r
  • Incidental Mutations
Homozygous null mutations result in male and female infertility associated with abnormal sexual maturation and hypogonadotropic hypogonadism.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000035773 Ensembl Gene Model | MGI Sequence Detail 5303 C57BL/6J ±  kb
transcript ENSMUST00000045529 Ensembl | MGI Sequence Detail 3163 Not Applicable  
polypeptide ENSMUSP00000040516 Ensembl | MGI Sequence Detail 396 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    26 from dbSNP Build 142
Protein
Information
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  • UniProt
    4 Sequences
  • Protein Ontology
    PR:000001426 KiSS-1 receptor
  • InterPro Domains
    IPR017452 GPCR, rhodopsin-like, 7TM
    IPR000276 G protein-coupled receptor, rhodopsin-like
    IPR008103 KiSS-1 peptide receptor
Molecular
Reagents
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  • All nucleic 8
    Genomic 1
    cDNA 6
    Primer pair 1

    Microarray probesets 2
References
more
  • Summaries
    All 75
    Developmental Gene Expression 3
    Diseases 5
    Gene Ontology 6
    Phenotypes 49
  • Earliest
    J:70348 Clements MK, et al., FMRFamide-related neuropeptides are agonists of the orphan G-protein-coupled receptor GPR54. Biochem Biophys Res Commun. 2001 Jun 29;284(5):1189-93
  • Latest
    J:232747 Min L, et al., RF9 Acts as a KISS1R Agonist In Vivo and In Vitro. Endocrinology. 2015 Dec;156(12):4639-48

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/20/2016
MGI 6.05
The Jackson Laboratory