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Kiss1r
Gene Detail
Symbol

Name
ID
Kiss1r
KISS1 receptor
MGI:2148793
Synonyms
Gpr54
Feature Type
protein coding gene
Genetic Map
Chromosome 10
39.72 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr10:79916971-79922273 bp, + strand
From Ensembl annotation of GRCm38

  5303 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:11411  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 2 western clawed frog; 1 zebrafish

HCOP human homology predictions: KISS1R
Protein SuperFamily: KiSS-1 receptor
Gene Tree: Kiss1r

Human
homologs
KISS1R, KISS1 receptor
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 84634
neXtProt AC: NX_Q969F8

Human Synonyms: AXOR12, CPPB1, GPR54, HH8, HOT7T175, KISS-1R

Human Chr (Location): 19p13.3; chr19:917342-921015 (+)  GRCh38.p2

Disease Associations: (2) Diseases Associated with Human KISS1R

Mutations,
alleles, and
phenotypes
All mutations/alleles(9) : Gene trapped(1) Targeted(8)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Homozygote null mice are infertile with abnormal sexual maturation associated with hypogonadotropism.
 
Human Diseases Modeled in Mice Using Kiss1r (1)    Mutations Annotated to Human Diseases (4)    Phenotype Images(2)
Interactions
Kiss1r interacts with 18 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (3 records)
Data Summary: Results (16)    Tissues (9)    Images (10)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 10
RT-PCR 6
cDNA source data(6)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase kiss1r ; ZFIN kiss1ra, kiss1rb    NEW 
Molecular
reagents
All nucleic(8) Genomic(1) cDNA(6) Primer pair(1)
Microarray probesets(2)
Other database
links
Ensembl Gene Model ENSMUSG00000035773 (Evidence)
Entrez Gene 114229 (Evidence)
UniGene 191035
DFCI TC1587687
NIA Mouse Gene Index U011729
Consensus CDS Project CCDS23998.1
International Mouse Phenotyping Consortium Status Kiss1r
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000035773 Ensembl Gene Model | MGI Sequence Detail 5303 C57BL/6J ±  kb
transcript ENSMUST00000045529 Ensembl | MGI Sequence Detail 3163 Not Applicable 
polypeptide ENSMUSP00000040516 Ensembl | MGI Sequence Detail 396 Not Applicable 

For the selected sequences
All sequences(33) RefSeq(13) UniProt(4)
Polymorphisms
SNPs within 2kb(26 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017452 GPCR, rhodopsin-like, 7TM
InterPro IPR000276 G protein-coupled receptor, rhodopsin-like
InterPro IPR008103 KiSS-1 peptide receptor
Protein Ontology PR:000001426 KiSS-1 receptor
References
(Earliest) J:70348 Clements MK, et al., FMRFamide-related neuropeptides are agonists of the orphan G-protein-coupled receptor GPR54. Biochem Biophys Res Commun. 2001 Jun 29;284(5):1189-93
(Latest) J:222091 Liu X, et al., Kisspeptin regulation of arcuate neuron excitability in kisspeptin receptor knockout mice. Endocrinology. 2015 May;156(5):1815-27
All references(70)
Disease annotation references (5)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory