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Kiss1r
Gene Detail
 Symbol
Name
ID
Kiss1r
KISS1 receptor
MGI:2148793
Synonyms Gpr54
Feature Type protein coding gene
Genetic Map
Chromosome 10
39.72 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr10:79916971-79922273 bp, + strand
From NCBI annotation of GRCm38

  5303 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:11411  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 2 western clawed frog; 1 zebrafish

Protein SuperFamily: KiSS-1 receptor
Gene Tree: Kiss1r

Human
homologs
Human Homolog KISS1R, KISS1 receptor
NCBI Gene ID 84634
neXtProt AC  NX_Q969F8
Human Synonyms  AXOR12, CPPB1, GPR54, HH8, HOT7T175, KISS-1R
Human Chr (Location)  19p13.3; chr19:917342-921015 (+)  GRCh38
Disease Associations  (2) Diseases Associated with Human KISS1R
Mutations,
alleles, and
phenotypes
All mutations/alleles(8) : Gene trapped(1) Targeted(7)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygote null mice are infertile with abnormal sexual maturation associated with hypogonadotropism.
 
Human Diseases Modeled Using Mouse Kiss1r (1)    Alleles Annotated to Human Diseases(4)   
Interactions
Kiss1r interacts with 18 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (27 annotations)
Process activation of MAPKK activity, arachidonic acid secretion, ...
Component cell surface, integral component of membrane, ...
Function G-protein coupled peptide receptor activity, G-protein coupled receptor activity, ...
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (16)    Tissues (9)    Images (10)
Theiler Stages: 20, 25, 27
Assay TypeResults
Immunohistochemistry 10
RT-PCR 6
cDNA source data(6)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(8) Genomic(1) cDNA(6) Primer pair(1)
Microarray probesets(2)
Other database
links
Ensembl Gene ModelENSMUSG00000035773 (Evidence)
Entrez Gene114229 (Evidence)
UniGene191035
DFCITC1587687
NIA Mouse Gene IndexU011729
Consensus CDS ProjectCCDS23998.1
International Mouse Knockout Project StatusKiss1r
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 114229 NCBI Gene Model | MGI Sequence Detail 5303 C57BL/6J ±  kb
transcript NM_053244 RefSeq | MGI Sequence Detail 3163 C57BL/6 
polypeptide Q91V45 UniProt | EBI | MGI Sequence Detail 396 Not Applicable 

For the selected sequences
All sequences(33) RefSeq(13) UniProt(4)
Polymorphisms SNPs within 2kb(26 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017452 GPCR, rhodopsin-like, 7TM
InterPro IPR000276 G protein-coupled receptor, rhodopsin-like
InterPro IPR008103 KiSS-1 peptide receptor
Protein Ontology PR:000001426 KiSS-1 receptor
Graphical View of Protein Domain Structure
References (Earliest) J:70348 Clements MK, et al., FMRFamide-related neuropeptides are agonists of the orphan G-protein-coupled receptor GPR54. Biochem Biophys Res Commun. 2001 Jun 29;284(5):1189-93
(Latest) J:206044 Kirilov M, et al., Dependence of fertility on kisspeptin-Gpr54 signaling at the GnRH neuron. Nat Commun. 2013;4:2492
All references(56)
Disease annotation references (5)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/23/2014
MGI 5.19
The Jackson Laboratory