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Kiss1r
Gene Detail
Symbol

Name
ID
Kiss1r
KISS1 receptor
MGI:2148793
Synonyms
Gpr54
Feature Type
protein coding gene
Genetic Map
Chromosome 10
39.72 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr10:79916971-79922273 bp, + strand
From Ensembl annotation of GRCm38

  5303 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:11411  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 2 western clawed frog; 1 zebrafish

Protein SuperFamily: KiSS-1 receptor
Gene Tree: Kiss1r

Human
homologs
Human Homolog KISS1R, KISS1 receptor
NCBI Gene ID 84634
neXtProt AC  NX_Q969F8
Human Synonyms  AXOR12, CPPB1, GPR54, HH8, HOT7T175, KISS-1R
Human Chr (Location)  19p13.3; chr19:917342-921015 (+)  GRCh38
Disease Associations  (2) Diseases Associated with Human KISS1R
Mutations,
alleles, and
phenotypes
All mutations/alleles(8) : Gene trapped(1) Targeted(7)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygote null mice are infertile with abnormal sexual maturation associated with hypogonadotropism.
 
Human Diseases Modeled Using Mouse Kiss1r (1)    Alleles Annotated to Human Diseases(4)   
Interactions
Kiss1r interacts with 18 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (2 records)
Data Summary: Results (16)    Tissues (9)    Images (10)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 10
RT-PCR 6
cDNA source data(6)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(8) Genomic(1) cDNA(6) Primer pair(1)
Microarray probesets(2)
Other database
links
Ensembl Gene ModelENSMUSG00000035773 (Evidence)
Entrez Gene114229 (Evidence)
UniGene191035
DFCITC1587687
NIA Mouse Gene IndexU011729
Consensus CDS ProjectCCDS23998.1
International Mouse Knockout Project StatusKiss1r
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000035773 Ensembl Gene Model | MGI Sequence Detail 5303 C57BL/6J ±  kb
transcript ENSMUST00000045529 Ensembl | MGI Sequence Detail 3163 Not Applicable 
polypeptide ENSMUSP00000040516 Ensembl | MGI Sequence Detail 396 Not Applicable 

For the selected sequences
All sequences(36) RefSeq(13) UniProt(7)
Polymorphisms
SNPs within 2kb(26 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017452 GPCR, rhodopsin-like, 7TM
InterPro IPR000276 G protein-coupled receptor, rhodopsin-like
InterPro IPR008103 KiSS-1 peptide receptor
Protein Ontology PR:000001426 KiSS-1 receptor
References
(Earliest) J:70348 Clements MK, et al., FMRFamide-related neuropeptides are agonists of the orphan G-protein-coupled receptor GPR54. Biochem Biophys Res Commun. 2001 Jun 29;284(5):1189-93
(Latest) J:214375 Calder M, et al., Implantation failure in female Kiss1-/- mice is independent of their hypogonadic state and can be partially rescued by leukemia inhibitory factor. Endocrinology. 2014 Aug;155(8):3065-78
All references(60)
Disease annotation references (5)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/18/2014
MGI 5.20
The Jackson Laboratory