Kiss1r^tm1Coll
Targeted Allele Detail

Summary

• Symbol: Kiss1r^tm1Coll
• Name: KISS1 receptor; targeted mutation 1, William H Colledge
• MGI ID: MGI:3530566
• Synonyms: gpr54^-, Gpr54^tm1Par, Gpr54^tm1PTL
• Gene: Kiss1r Location: Chr10:79752805-79758107 bp, + strand Genetic Position: Chr10, 39.72 cM
• Alliance: Kiss1r^tm1Coll page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:96442
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: An IRES-Betagal-MC-neo cassette was inserted into exon 1, replacing the 3' end of exon 1, intron 1 and the 5' end of exon 2. The deleted sequence encoded transmembrane loops 1 and 2 and the encompassing domains. RT-PCR confirmed that the resulting allele was a null. (J:96442)

Disease models

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	13 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Kiss1r Mutation: 20 strains or lines available

References

• Original: J:96442 Seminara SB, et al., The GPR54 gene as a regulator of puberty. N Engl J Med. 2003 Oct 23;349(17):1614-27
• All: 20 reference(s)