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Slc6a8
Gene Detail
Symbol

Name
ID
Slc6a8
solute carrier family 6 (neurotransmitter transporter, creatine), member 8
MGI:2147834
Synonyms
Creat, CRT
Feature Type
protein coding gene
Genetic Map
Chromosome X
37.38 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
ChrX:73673150-73682502 bp, + strand
From VEGA annotation of GRCm38

  9353 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:4113  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: SLC6A8
Gene Tree: Slc6a8

Human
homologs
SLC6A8, solute carrier family 6 (neurotransmitter transporter), member 8
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 6535
neXtProt AC: NX_P48029

Human Synonyms: CCDS1, CRT, CRTR, CT1, CTR5

Human Chr (Location): Xq28; chrX:153688297-153696593 (+)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human SLC6A8

Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Gene trapped(1) Targeted(5)
 
Male mice hemizygous for a targeted allele exhibit decreased body weight, decreased creatine concentrations, impaired short term object recognition, impaired contextual conditioning, altered locomotor activity, and increased serotonine levels in the brain.
 
Human Diseases Modeled in Mice Using Slc6a8 (1)    Mutations Annotated to Human Diseases (2)   
Interactions
Slc6a8 interacts with 344 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (5 records)
Data Summary: Results (211)    Tissues (117)    Images (22)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 209
RT-PCR 2
cDNA source data(107)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase slc6a8 ; ZFIN slc6a8    NEW 
Molecular
reagents
All nucleic(110) cDNA(108) Primer pair(2)
Microarray probesets(6)
Other database
links
VEGA Gene Model OTTMUSG00000017696 (Evidence)
Ensembl Gene Model ENSMUSG00000019558 (Evidence)
Entrez Gene 102857 (Evidence)
UniGene 274553
DFCI TC1705224, TC1574547, TC1602564, TC1586843
DoTS DT.111029484, DT.91338538, DT.94169278
NIA Mouse Gene Index U019941
Consensus CDS Project CCDS30208.1, CCDS53098.1
International Mouse Phenotyping Consortium Status Slc6a8
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000017696 VEGA Gene Model | MGI Sequence Detail 9353 C57BL/6J ±  kb
transcript OTTMUST00000042894 VEGA | MGI Sequence Detail 3964 Not Applicable 
polypeptide OTTMUSP00000019279 VEGA | MGI Sequence Detail 640 Not Applicable 

For the selected sequences
All sequences(93) RefSeq(6) UniProt(9)
Polymorphisms
RFLP(1) : SNPs within 2kb(13 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000175 Sodium:neurotransmitter symporter
InterPro IPR002984 Sodium:neurotransmitter symporter, creatine
Protein Ontology PR:000015192 sodium- and chloride-dependent creatine transporter 1
References
(Earliest) J:19724 Nash SR, et al., Cloning, pharmacological characterization, and genomic localization of the human creatine transporter. Receptors Channels. 1994;2(2):165-74
(Latest) J:204566 Gendrel AV, et al., Epigenetic functions of smchd1 repress gene clusters on the inactive X chromosome and on autosomes. Mol Cell Biol. 2013 Aug;33(16):3150-65
All references(39)
Disease annotation references (2)
Other
accession IDs
MGD-MRK-2133, MGI:88493

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory