Slc6a8
Gene Detail

Symbol Name ID

Slc6a8 solute carrier family 6 (neurotransmitter transporter, creatine), member 8 MGI:2147834

Synonyms

Creat, CRT

Feature Type

protein coding gene

Genetic Map

Chromosome X

37.38 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

ChrX:73673150-73682502 bp, + strand From VEGA annotation of GRCm38   9353 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:4113  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 zebrafish

Gene Tree: Slc6a8

Human homologs

Human Homolog		SLC6A8, solute carrier family 6 (neurotransmitter transporter, creatine), member 8
NCBI Gene ID		6535
neXtProt AC		NX_P48029
Human Synonyms		CRT, CRTR, CT1
Human Chr (Location)		Xq28; chrX:152953752-152962048 (+)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human SLC6A8

Alleles and phenotypes

All alleles(6) : Targeted(5) Gene trapped(1)
 

Male mice hemizygous for a targeted allele exhibit decreased body weight, decreased creatine concentrations, impaired short term object recognition, impaired contextual conditioning, altered locomotor activity, and increased serotonine levels in the brain.

 
Human Diseases Modeled Using Mouse Slc6a8 (1)    Alleles Annotated to Human Diseases(2)   

Gene Ontology (GO) classifications

All GO classifications: (18 annotations)

Process	choline transport, creatine transport, ...
Component	integral to membrane, integral to plasma membrane, ...
Function	choline transmembrane transporter activity, creatine:sodium symporter activity, ...

External Resources: FuncBase

Expression

Literature Summary: (4 records)
Data Summary: Results (211)    Tissues (117)    Images (22)
Theiler Stages: 21, 22, 23, 28

Assay Type	Results
RNA in situ	209
RT-PCR	2

cDNA source data(107)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(110) cDNA(108) Primer pair(2)
Microarray probesets(6)

Other database links

VEGA Gene Model	OTTMUSG00000017696 (Evidence)
Ensembl Gene Model	ENSMUSG00000019558 (Evidence)
Entrez Gene	102857 (Evidence)
UniGene	274553
DFCI	TC1574547, TC1586843, TC1602564, TC1705224
DoTS	DT.111029484, DT.91338538, DT.94169278
NIA Mouse Gene Index	U019941
Consensus CDS Project	CCDS30208.1, CCDS53098.1
International Mouse Knockout Project Status	Slc6a8

Sequences

Length	Strain/Species
genomic	OTTMUSG00000017696	VEGA Gene Model | MGI Sequence Detail	9353	C57BL/6J
transcript	OTTMUST00000042894	VEGA | MGI Sequence Detail	3964	Not Applicable
polypeptide	OTTMUSP00000019279	VEGA | MGI Sequence Detail	640	Not Applicable

All sequences(86) RefSeq(5) UniProt(8)

Polymorphisms

RFLP(1) : SNPs(8 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR000175	Sodium:neurotransmitter symporter
InterPro	IPR002984	Sodium:neurotransmitter symporter, creatine
Protein Ontology	PR:000015192	sodium- and chloride-dependent creatine transporter 1

References

(Earliest) J:19724 Nash SR, et al., Cloning, pharmacological characterization, and genomic localization of the human creatine transporter. Receptors Channels. 1994;2(2):165-74
(Latest) J:190081 Kurosawa Y, et al., Cyclocreatine treatment improves cognition in mice with creatine transporter deficiency. J Clin Invest. 2012 Aug 1;122(8):2837-46
All references(39)

Other accession IDs

MGD-MRK-2133, MGI:88493