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Slc6a8
Gene Detail
 Symbol
Name
ID
Slc6a8
solute carrier family 6 (neurotransmitter transporter, creatine), member 8
MGI:2147834
Synonyms Creat, CRT
Feature Type protein coding gene
Genetic Map
Chromosome X
37.38 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
ChrX:73673150-73682502 bp, + strand
From VEGA annotation of GRCm38

  9353 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:4113  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 western clawed frog; 1 zebrafish

Gene Tree: Slc6a8

Human
homologs
Human Homolog SLC6A8, solute carrier family 6 (neurotransmitter transporter), member 8
NCBI Gene ID 6535
neXtProt AC  NX_P48029
Human Synonyms  CCDS1, CRT, CRTR, CT1, CTR5
Human Chr (Location)  Xq28; chrX:153688297-153696593 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human SLC6A8
Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Gene trapped(1) Targeted(5)
 
Male mice hemizygous for a targeted allele exhibit decreased body weight, decreased creatine concentrations, impaired short term object recognition, impaired contextual conditioning, altered locomotor activity, and increased serotonine levels in the brain.
 
Human Diseases Modeled Using Mouse Slc6a8 (1)    Alleles Annotated to Human Diseases(2)   
Interactions
Slc6a8 interacts with 345 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (22 annotations)
Process choline transport, cofactor transport, ...
Component integral component of membrane, integral component of plasma membrane, ...
Function choline transmembrane transporter activity, creatine:sodium symporter activity, ...
External Resources: FuncBase
Expression
Literature Summary: (4 records)
Data Summary: Results (211)    Tissues (117)    Images (22)
Theiler Stages: 21, 22, 23, 27
Assay TypeResults
RNA in situ 209
RT-PCR 2
cDNA source data(107)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(110) cDNA(108) Primer pair(2)
Microarray probesets(6)
Other database
links
VEGA Gene ModelOTTMUSG00000017696 (Evidence)
Ensembl Gene ModelENSMUSG00000019558 (Evidence)
Entrez Gene102857 (Evidence)
UniGene274553
DFCITC1574547, TC1586843, TC1602564, TC1705224
DoTSDT.111029484, DT.91338538, DT.94169278
NIA Mouse Gene IndexU019941
Consensus CDS ProjectCCDS30208.1, CCDS53098.1
International Mouse Knockout Project StatusSlc6a8
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000017696 VEGA Gene Model | MGI Sequence Detail 9353 C57BL/6J ±  kb
transcript OTTMUST00000042894 VEGA | MGI Sequence Detail 3964 Not Applicable 
polypeptide OTTMUSP00000019279 VEGA | MGI Sequence Detail 640 Not Applicable 

For the selected sequences
All sequences(89) RefSeq(6) UniProt(9)
Polymorphisms RFLP(1) : SNPs within 2kb(13 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000175 Sodium:neurotransmitter symporter
InterPro IPR002984 Sodium:neurotransmitter symporter, creatine
Protein Ontology PR:000015192 sodium- and chloride-dependent creatine transporter 1
References (Earliest) J:19724 Nash SR, et al., Cloning, pharmacological characterization, and genomic localization of the human creatine transporter. Receptors Channels. 1994;2(2):165-74
(Latest) J:190081 Kurosawa Y, et al., Cyclocreatine treatment improves cognition in mice with creatine transporter deficiency. J Clin Invest. 2012 Aug 1;122(8):2837-46
All references(39)
Disease annotation references (2)
Other
accession IDs
MGD-MRK-2133, MGI:88493

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory