Symbol
Name
ID

Slc6a8
solute carrier family 6 (neurotransmitter transporter, creatine), member 8
MGI:2147834

Phenotype annotations related to homeostasis/metabolism

Darker colors indicate more annotations

Human Phenotypes	Elevated circulating creatine concentration	Elevated urinary creatine/creatinine ratio
Disease(s) Associated with SLC6A8	Elevated circulating creatine concentration	Elevated urinary creatine/creatinine ratio
cerebral creatine deficiency syndrome 1

Mouse Phenotypes

decreased aerobic running capacity

decreased circulating creatine level

decreased urine creatine level

increased urine creatine level

decreased creatine level

decreased fasting circulating glucose level

decreased circulating glucose level

improved glucose tolerance

increased serotonin level

abnormal ion homeostasis

abnormal enzyme/coenzyme activity

Availability

Mouse Genotype

Slc6a8^tm1.2Clar/Y

Slc6a8^tm1.2Lbar/Y

Slc6a8^{tm1e(KOMP)Wtsi}/Y

Slc6a8^tm1.1Clar/Y
Tg(Camk2a-cre)2Gsc/0 (conditional)

Slc6a8^tm1.1Lbar/Y
Tg(Nes-cre)1Kln/0 (conditional)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/23/2024 MGI 6.23