Fbxo11
Gene Detail

Symbol Name ID

Fbxo11 F-box protein 11 MGI:2147134

Synonyms

GENA 104, Jf

Feature Type

protein coding gene

Genetic Map

Chromosome 17

57.87 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr17:87990859-88065291 bp, - strand From VEGA annotation of GRCm38   74433 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:11843  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Fbxo11

Human homologs

Human Homolog		FBXO11, F-box protein 11
NCBI Gene ID		80204
neXtProt AC		NX_Q86XK2
Human Synonyms		FBX11, PRMT9, UBR6, VIT1
Human Chr (Location)		2p16.3; chr2:48034059-48132932 (-)  GRCh37.p10

Alleles and phenotypes

All alleles(30) : Targeted(4) Gene trapped(24) Chemically induced(2)
 

A dominant ENU mutation at this locus results in deafness, middle ear abnormalities, chronic otitis media and slightly reduced body weight in heterozygous mice.

 
Human Diseases Modeled Using Mouse Fbxo11 (1)    Alleles Annotated to Human Diseases(2)   

Gene Ontology (GO) classifications

All GO classifications: (10 annotations)

Process	cellular protein modification process, peptidyl-arginine N-methylation, ...
Component	cytoplasm, nucleolus, ...
Function	metal ion binding, protein-arginine N-methyltransferase activity, ...

External Resources: FuncBase

Expression

Literature Summary: (6 records)
Data Summary: Results (53)    Tissues (32)    Images (6)
Theiler Stages: 17, 18, 21, 23

Assay Type	Results
RNA in situ	53

cDNA source data(16)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(17) Genomic(1) cDNA(16)
Microarray probesets(2)

Other database links

VEGA Gene Model	OTTMUSG00000020228 (Evidence)
Ensembl Gene Model	ENSMUSG00000005371 (Evidence)
Entrez Gene	225055 (Evidence)
DFCI	TC1597523, TC1662895
NIA Mouse Gene Index	U038141
Consensus CDS Project	CCDS37717.1
International Mouse Knockout Project Status	Fbxo11

Sequences

Length	Strain/Species
genomic	OTTMUSG00000020228	VEGA Gene Model | MGI Sequence Detail	74433	C57BL/6J
transcript	OTTMUST00000048033	VEGA | MGI Sequence Detail	4019	Not Applicable
polypeptide	OTTMUSP00000021920	VEGA | MGI Sequence Detail	930	Not Applicable

All sequences(45) RefSeq(3) UniProt(6)

Polymorphisms

SNPs(192 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR006633	Carbohydrate-binding/sugar hydrolysis domain
InterPro	IPR001810	F-box domain, cyclin-like
InterPro	IPR006626	Parallel beta-helix repeat
InterPro	IPR022441	Parallel beta-helix repeat-2
InterPro	IPR012334	Pectin lyase fold
InterPro	IPR011050	Pectin lyase fold/virulence factor
InterPro	IPR007742	Periplasmic copper-binding protein NosD, beta helix domain
InterPro	IPR003126	Zinc finger, N-recognin
Protein Ontology	PR:000007388	F-box only protein 11

References

(Earliest) J:8500 Van der Bliek AM, et al., Overexpression and amplification of five genes in a multidrug-resistant Chinese hamster ovary cell line. Mol Cell Biol. 1986 May;6(5):1671-8
(Latest) J:183391 Mann KM, et al., Sleeping Beauty mutagenesis reveals cooperating mutations and pathways in pancreatic adenocarcinoma. Proc Natl Acad Sci U S A. 2012 Apr 17;109(16):5934-41
All references(46)

Other accession IDs

MGI:1861993