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Fbxo11
Gene Detail
Symbol

Name
ID
Fbxo11
F-box protein 11
MGI:2147134
Synonyms
GENA 104, Jf
Feature Type
protein coding gene
Genetic Map
Chromosome 17
57.87 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr17:87990859-88065291 bp, - strand
From VEGA annotation of GRCm38

  74433 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:11843  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Fbxo11

Human
homologs
Human Homolog FBXO11, F-box protein 11
NCBI Gene ID 80204
neXtProt AC  NX_Q86XK2
Human Synonyms  FBX11, PRMT9, UBR6, VIT1
Human Chr (Location)  2p16.3; chr2:47806920-47906385 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(30) : Chemically induced (ENU)(2) Gene trapped(24) Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
A dominant ENU mutation at this locus results in deafness, middle ear abnormalities, chronic otitis media and slightly reduced body weight in heterozygous mice.
 
Human Diseases Modeled Using Mouse Fbxo11 (1)    Alleles Annotated to Human Diseases(2)   
Interactions
Fbxo11 interacts with 336 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (11 annotations)
Process cellular protein modification process, peptidyl-arginine N-methylation, ...
Component chromosome, cytoplasm, ...
Function metal ion binding, protein-arginine N-methyltransferase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (6 records)
Data Summary: Results (53)    Tissues (32)    Images (6)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 53
cDNA source data(16)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(17) Genomic(1) cDNA(16)
Microarray probesets(2)
Other database
links
VEGA Gene ModelOTTMUSG00000020228 (Evidence)
Ensembl Gene ModelENSMUSG00000005371 (Evidence)
Entrez Gene225055 (Evidence)
DFCITC1662895, TC1597523
NIA Mouse Gene IndexU038141
Consensus CDS ProjectCCDS37717.1
International Mouse Knockout Project StatusFbxo11
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000020228 VEGA Gene Model | MGI Sequence Detail 74433 C57BL/6J ±  kb
transcript OTTMUST00000048033 VEGA | MGI Sequence Detail 4019 Not Applicable 
polypeptide OTTMUSP00000021920 VEGA | MGI Sequence Detail 930 Not Applicable 

For the selected sequences
All sequences(56) RefSeq(7) UniProt(11)
Polymorphisms
SNPs within 2kb(273 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR006633 Carbohydrate-binding/sugar hydrolysis domain
InterPro IPR001810 F-box domain, cyclin-like
InterPro IPR006626 Parallel beta-helix repeat
InterPro IPR022441 Parallel beta-helix repeat-2
InterPro IPR012334 Pectin lyase fold
InterPro IPR011050 Pectin lyase fold/virulence factor
InterPro IPR007742 Periplasmic copper-binding protein NosD, beta helix domain
InterPro IPR003126 Zinc finger, N-recognin
Protein Ontology PR:000007388 F-box only protein 11
References
(Earliest) J:8500 Van der Bliek AM, et al., Overexpression and amplification of five genes in a multidrug-resistant Chinese hamster ovary cell line. Mol Cell Biol. 1986 May;6(5):1671-8
(Latest) J:183391 Mann KM, et al., Sleeping Beauty mutagenesis reveals cooperating mutations and pathways in pancreatic adenocarcinoma. Proc Natl Acad Sci U S A. 2012 Apr 17;109(16):5934-41
All references(47)
Disease annotation references (1)
Other
accession IDs
MGI:1861993

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
11/11/2014
MGI 5.20
The Jackson Laboratory