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Fbxo11 Gene Detail
Summary
  • Symbol
    Fbxo11
  • Name
    F-box protein 11
  • Synonyms
    GENA 104, Jf
  • Feature Type
    protein coding gene
  • IDs
    MGI:2147134
    NCBI Gene: 225055
  • Gene Overview
    MyGene.info: FBXO11
  • Alliance
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:87990859-88065291 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 17, 57.87 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    273 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2147134
protein coding gene Chr17:87990859-88066092 (-)
129S1/SvImJ MGP_129S1SvImJ_G0024108
protein coding gene Chr17:91443225-91524166 (-)
A/J MGP_AJ_G0024068
protein coding gene Chr17:88495921-88572099 (-)
AKR/J MGP_AKRJ_G0024037
protein coding gene Chr17:89969384-90046048 (-)
BALB/cJ MGP_BALBcJ_G0024069
protein coding gene Chr17:88326585-88403705 (-)
C3H/HeJ MGP_C3HHeJ_G0023834
protein coding gene Chr17:90873759-90950235 (-)
C57BL/6NJ MGP_C57BL6NJ_G0024514
protein coding gene Chr17:94617239-94704809 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0021952
protein coding gene Chr17:83568632-83649126 (-)
CAST/EiJ MGP_CASTEiJ_G0023313
protein coding gene Chr17:91704129-91783051 (-)
CBA/J MGP_CBAJ_G0023807
protein coding gene Chr17:98614083-98701491 (-)
DBA/2J MGP_DBA2J_G0023936
protein coding gene Chr17:86894091-86968554 (-)
FVB/NJ MGP_FVBNJ_G0023902
protein coding gene Chr17:86412025-86487149 (-)
LP/J MGP_LPJ_G0024020
protein coding gene Chr17:92240255-92318559 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0023930
protein coding gene Chr17:98437331-98515199 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0024559
protein coding gene Chr17:90517956-90603435 (-)
PWK/PhJ MGP_PWKPhJ_G0023058
protein coding gene Chr17:86568384-86645604 (-)
SPRET/EiJ MGP_SPRETEiJ_G0022869
protein coding gene Chr17:87259230-87287125 (-)
WSB/EiJ MGP_WSBEiJ_G0023379
protein coding gene Chr17:91331464-91372660 (-)



Homology
more
  • Human Ortholog
    FBXO11, F-box protein 11
  • Vertebrate Orthologs
    9
  • Human Ortholog
    FBXO11, F-box protein 11
    Orthology source: HGNC, HomoloGene
  • Synonyms
    FBX11, IDDFBA, PRMT9, UBR6, UG063H01, VIT1
  • Links
    NCBI Gene ID: 80204
    neXtProt AC: NX_Q86XK2
    UniProt: Q86XK2

  • Chr Location
    2p16.3; chr2:47806920-47905793 (-)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with Fbxo11 mouse models

Human Disease Mouse Models
      
IDs
View 3 models
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    33 phenotypes from 4 alleles in 6 genetic backgrounds
    17 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for ENU-induced mutations exhibit cleft palate, facial clefting, and perinatal lethality. Mice homozygous for a knock-out allele show neonatal lethality, thick epidermis, decreased hair follicle number, absent keratohyalin granules, and increased epidermal Snail protein levels.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000005371 Ensembl Gene Model | MGI Sequence Detail 74433 C57BL/6J ±  kb
    transcript ENSMUST00000005504 Ensembl | MGI Sequence Detail 4019 Not Applicable  
    polypeptide ENSMUSP00000005504 Ensembl | MGI Sequence Detail 930 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 24
      Genomic 2
      cDNA 22

      Microarray probesets 2
    Other
    Accession IDs
    less
    MGI:1861993
    References
    more
    • Summaries
      All 51
      Developmental Gene Expression 8
      Diseases 2
      Gene Ontology 6
      Phenotypes 17
    • Earliest
      J:8500 Van der Bliek AM, et al., Overexpression and amplification of five genes in a multidrug-resistant Chinese hamster ovary cell line. Mol Cell Biol. 1986 May;6(5):1671-8
    • Latest
      J:236059 Schneider C, et al., FBXO11 inactivation leads to abnormal germinal-center formation and lymphoproliferative disease. Blood. 2016 Aug 4;128(5):660-6

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    12/04/2018
    MGI 6.13
    The Jackson Laboratory