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Fbxo11 Gene Detail
Summary
  • Symbol
    Fbxo11
  • Name
    F-box protein 11
  • Synonyms
    GENA 104, Jf
  • Feature Type
    protein coding gene
  • IDs
    MGI:2147134
    NCBI Gene: 225055
  • Gene Overview
    MyGene.info: FBXO11
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr17:87990859-88065291 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      74433 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 17, 57.87 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    FBXO11, F-box protein 11
  • Vertebrate Orthologs
    9
  • Human Ortholog
    FBXO11, F-box protein 11
    Orthology source: HomoloGene, HGNC
  • Synonyms
    FBX11, PRMT9, UBR6, UG063H01, VIT1
  • Links
    NCBI Gene ID: 80204
    neXtProt AC: NX_Q86XK2
    UniProt: Q86XK2

  • Chr Location
    2p16.3; chr2:47806920-47905793 (-)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with Fbxo11 mouse models

Human Disease Mouse Models
      
IDs
View 3 models
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    33 phenotypes from 4 alleles in 6 genetic backgrounds
    17 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for ENU-induced mutations exhibit cleft palate, facial clefting, and perinatal lethality. Mice homozygous for a knock-out allele show neonatal lethality, thick epidermis, decreased hair follicle number, absent keratohyalin granules, and increased epidermal Snail protein levels.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000020228 VEGA Gene Model | MGI Sequence Detail 74433 C57BL/6J ±  kb
    transcript OTTMUST00000048033 VEGA | MGI Sequence Detail 4019 Not Applicable  
    polypeptide OTTMUSP00000021920 VEGA | MGI Sequence Detail 930 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      273 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 24
      Genomic 2
      cDNA 22

      Microarray probesets 2
    Other
    Accession IDs
    less
    MGI:1861993
    References
    more
    • Summaries
      All 52
      Developmental Gene Expression 8
      Diseases 2
      Gene Ontology 6
      Phenotypes 17
    • Earliest
      J:8500 Van der Bliek AM, et al., Overexpression and amplification of five genes in a multidrug-resistant Chinese hamster ovary cell line. Mol Cell Biol. 1986 May;6(5):1671-8
    • Latest
      J:236059 Schneider C, et al., FBXO11 inactivation leads to abnormal germinal-center formation and lymphoproliferative disease. Blood. 2016 Aug 4;128(5):660-6

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    07/10/2018
    MGI 6.12
    The Jackson Laboratory