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Fbxo11
Gene Detail
Symbol

Name
ID
Fbxo11
F-box protein 11
MGI:2147134
Synonyms
GENA 104, Jf
Feature Type
protein coding gene
Genetic Map
Chromosome 17
57.87 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr17:87990859-88065291 bp, - strand
From VEGA annotation of GRCm38

  74433 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:11843  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: FBXO11
Gene Tree: Fbxo11

Human
homologs
FBXO11, F-box protein 11
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 80204
neXtProt AC: NX_Q86XK2

Human Synonyms: FBX11, PRMT9, UBR6, UG063H01, VIT1

Human Chr (Location): 2p16.3; chr2:47806920-47906535 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(31) : Chemically induced (ENU)(2) Gene trapped(24) Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
 
A dominant ENU mutation at this locus results in deafness, middle ear abnormalities, chronic otitis media and slightly reduced body weight in heterozygous mice.
 
Human Diseases Modeled in Mice Using Fbxo11 (1)    Mutations Annotated to Human Diseases (2)   
Interactions
Fbxo11 interacts with 335 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (13 annotations)
Process cellular protein modification process, peptidyl-arginine N-methylation, ...
Component chromosome, cytoplasm, ...
Function metal ion binding, protein-arginine N-methyltransferase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (7 records)
Data Summary: Results (53)    Tissues (32)    Images (6)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 53
cDNA source data(16)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: GEISHA FBXO11 ; Xenbase fbxo11 ; ZFIN fbxo11a    NEW 
Molecular
reagents
All nucleic(17) Genomic(1) cDNA(16)
Microarray probesets(2)
Other database
links
VEGA Gene Model OTTMUSG00000020228 (Evidence)
Ensembl Gene Model ENSMUSG00000005371 (Evidence)
Entrez Gene 225055 (Evidence)
DFCI TC1597523, TC1662895
NIA Mouse Gene Index U038141
Consensus CDS Project CCDS37717.1
International Mouse Phenotyping Consortium Status Fbxo11
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000020228 VEGA Gene Model | MGI Sequence Detail 74433 C57BL/6J ±  kb
transcript OTTMUST00000048033 VEGA | MGI Sequence Detail 4019 Not Applicable 
polypeptide OTTMUSP00000021920 VEGA | MGI Sequence Detail 930 Not Applicable 

For the selected sequences
All sequences(51) RefSeq(7) UniProt(6)
Polymorphisms
SNPs within 2kb(273 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR006633 Carbohydrate-binding/sugar hydrolysis domain
InterPro IPR001810 F-box domain, cyclin-like
InterPro IPR006626 Parallel beta-helix repeat
InterPro IPR022441 Parallel beta-helix repeat-2
InterPro IPR012334 Pectin lyase fold
InterPro IPR011050 Pectin lyase fold/virulence factor
InterPro IPR007742 Periplasmic copper-binding protein NosD, beta helix domain
InterPro IPR003126 Zinc finger, N-recognin
Protein Ontology PR:000007388 F-box only protein 11
References
(Earliest) J:8500 Van der Bliek AM, et al., Overexpression and amplification of five genes in a multidrug-resistant Chinese hamster ovary cell line. Mol Cell Biol. 1986 May;6(5):1671-8
(Latest) J:220308 Jin Y, et al., FBXO11 promotes ubiquitination of the Snail family of transcription factors in cancer progression and epidermal development. Cancer Lett. 2015 Jun 28;362(1):70-82
All references(47)
Disease annotation references (1)
Other
accession IDs
MGI:1861993

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/30/2015
MGI 5.22
The Jackson Laboratory