About   Help   FAQ
Xpo1
Gene Detail
Symbol

Name
ID
Xpo1
exportin 1, CRM1 homolog (yeast)
MGI:2144013
Synonyms
Crm1
Feature Type
protein coding gene
Genetic Map
Chromosome 11
14.28 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr11:23256055-23298249 bp, + strand
From VEGA annotation of GRCm38

  42195 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:2554  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: XPO1
Protein SuperFamily: exportin 1
Gene Tree: Xpo1

Human
homologs
XPO1, exportin 1
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 7514
neXtProt AC: NX_O14980

Human Synonyms: CRM1, emb, exp1

Human Chr (Location): 2p15; chr2:61477934-61538522 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(89) : Gene trapped(88) Targeted(1)
Incidental mutations (data from Mutagenetix , APF , CvDC )
Interactions
Xpo1 interacts with 338 markers (Mir1b, Mir7-1, Mir9-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (36 annotations)
Process intracellular protein transport, mRNA transport, ...
Component annulate lamellae, cell, ...
Function nucleocytoplasmic transporter activity, protein binding, ...
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (109)    Tissues (102)    Images (17)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 8
RNA in situ 93
RT-PCR 8
cDNA source data(231)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase xpo1 ; ZFIN xpo1a, xpo1b    NEW 
Molecular
reagents
All nucleic(233) cDNA(231) Primer pair(2)
Microarray probesets(6)
Other database
links
VEGA Gene Model OTTMUSG00000005274 (Evidence)
Ensembl Gene Model ENSMUSG00000020290 (Evidence)
Entrez Gene 103573 (Evidence)
UniGene 217547
DFCI TC1573004, TC1607942, TC1609760, TC1622705
DoTS DT.101288722, DT.102557155, DT.495143, DT.94167039, DT.94331913
NIA Mouse Gene Index U012382
PDB 3GJX, 3NBY, 3NBZ, 3NC0, 3NC1
Consensus CDS Project CCDS24475.1
International Mouse Phenotyping Consortium Status Xpo1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000005274 VEGA Gene Model | MGI Sequence Detail 42195 C57BL/6J ±  kb
transcript OTTMUST00000011750 VEGA | MGI Sequence Detail 6004 Not Applicable 
polypeptide OTTMUSP00000005444 VEGA | MGI Sequence Detail 1071 Not Applicable 

For the selected sequences
All sequences(74) RefSeq(10) UniProt(5)
Polymorphisms
SNPs within 2kb(32 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR011989 Armadillo-like helical
InterPro IPR016024 Armadillo-type fold
InterPro IPR014877 CRM1 C-terminal domain
InterPro IPR013598 Exportin-1/Importin-beta-like
InterPro IPR001494 Importin-beta, N-terminal domain
Protein Ontology PR:000017497 exportin-1
References
(Earliest) J:116366 Taagepera S, et al., Nuclear-cytoplasmic shuttling of C-ABL tyrosine kinase. Proc Natl Acad Sci U S A. 1998 Jun 23;95(13):7457-62
(Latest) J:193623 Monecke T, et al., Structural basis for cooperativity of CRM1 export complex formation. Proc Natl Acad Sci U S A. 2013 Jan 15;110(3):960-5
All references(59)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
08/25/2015
MGI 6.0
The Jackson Laboratory