Xpo1
Gene Detail

Symbol Name ID

Xpo1 exportin 1, CRM1 homolog (yeast) MGI:2144013

Synonyms

Crm1

Feature Type

protein coding gene

Genetic Map

Chromosome 11

14.28 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr11:23256055-23298249 bp, + strand From VEGA annotation of GRCm38   42195 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:2554  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: exportin 1
Gene Tree: Xpo1

Human homologs

Human Homolog		XPO1, exportin 1 (CRM1 homolog, yeast)
NCBI Gene ID		7514
neXtProt AC		NX_O14980
Human Synonyms		CRM1, emb, exp1
Human Chr (Location)		2p15; chr2:61705069-61765418 (-)  GRCh37.p10

Alleles and phenotypes

All alleles(89) : Targeted(1) Gene trapped(88)

Gene Ontology (GO) classifications

All GO classifications: (22 annotations)

Process	intracellular protein transport, mRNA transport, ...
Component	annulate lamellae, cytoplasm, ...
Function	protein binding, protein domain specific binding, ...

External Resources: FuncBase

Expression

Literature Summary: (2 records)
Data Summary: Results (116)    Tissues (106)    Images (17)
Theiler Stages: 1, 2, 3, 5, 22, 28

Assay Type	Results
Immunohistochemistry	8
RNA in situ	93
RT-PCR	15

cDNA source data(20)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(22) cDNA(20) Primer pair(2)
Microarray probesets(6)

Other database links

VEGA Gene Model	OTTMUSG00000005274 (Evidence)
Ensembl Gene Model	ENSMUSG00000020290 (Evidence)
Entrez Gene	103573 (Evidence)
DFCI	TC1573004, TC1607942, TC1609760, TC1622705
DoTS	DT.101288722, DT.102557155, DT.495143, DT.94167039, DT.94331913
NIA Mouse Gene Index	U012382
PDB	3GJX, 3NBY, 3NBZ, 3NC0, 3NC1
Consensus CDS Project	CCDS24475.1
International Mouse Knockout Project Status	Xpo1

Sequences

Length	Strain/Species
genomic	OTTMUSG00000005274	VEGA Gene Model | MGI Sequence Detail	42195	C57BL/6J
transcript	OTTMUST00000011750	VEGA | MGI Sequence Detail	6004	Not Applicable
polypeptide	OTTMUSP00000005444	VEGA | MGI Sequence Detail	1071	Not Applicable

All sequences(69) RefSeq(4) UniProt(6)

Polymorphisms

SNPs(27 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR011989	Armadillo-like helical
InterPro	IPR016024	Armadillo-type fold
InterPro	IPR014877	CRM1 C-terminal domain
InterPro	IPR013598	Exportin-1/Importin-beta-like
InterPro	IPR001494	Importin-beta, N-terminal
Protein Ontology	PR:000017497	exportin-1
Protein Ontology	PR:000027113	exportin-1 (mouse)

References

(Earliest) J:116366 Taagepera S, et al., Nuclear-cytoplasmic shuttling of C-ABL tyrosine kinase. Proc Natl Acad Sci U S A. 1998 Jun 23;95(13):7457-62
(Latest) J:173190 Pradet-Balade B, et al., CRM1 controls the composition of nucleoplasmic pre-snoRNA complexes to licence them for nucleolar transport. EMBO J. 2011 Jun 1;30(11):2205-18
All references(54)