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Xpo1
Gene Detail
 Symbol
Name
ID
Xpo1
exportin 1, CRM1 homolog (yeast)
MGI:2144013
Synonyms Crm1
Feature Type protein coding gene
Genetic Map
Chromosome 11
14.28 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr11:23256055-23298249 bp, + strand
From VEGA annotation of GRCm38

  42195 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:2554  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: exportin 1
Gene Tree: Xpo1

Human
homologs
Human Homolog XPO1, exportin 1
NCBI Gene ID 7514
neXtProt AC  NX_O14980
Human Synonyms  CRM1, emb, exp1
Human Chr (Location)  2p15; chr2:61477934-61538305 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(89) : Gene trapped(88) Targeted(1)
Incidental mutations (data from Mutagenetix , APF )
Interactions
Xpo1 interacts with 339 markers (Mir1b, Mir7-1, Mir9-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (34 annotations)
Process intracellular protein transport, mRNA transport, ...
Component annulate lamellae, cell, ...
Function nucleocytoplasmic transporter activity, protein binding, ...
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (109)    Tissues (102)    Images (17)
Theiler Stages: 1, 2, 3, 4, 22, 28
Assay TypeResults
Immunohistochemistry 8
RNA in situ 93
RT-PCR 8
cDNA source data(231)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(233) cDNA(231) Primer pair(2)
Microarray probesets(6)
Other database
links
VEGA Gene ModelOTTMUSG00000005274 (Evidence)
Ensembl Gene ModelENSMUSG00000020290 (Evidence)
Entrez Gene103573 (Evidence)
UniGene217547
DFCITC1573004, TC1607942, TC1609760, TC1622705
DoTSDT.101288722, DT.102557155, DT.495143, DT.94167039, DT.94331913
NIA Mouse Gene IndexU012382
PDB3GJX, 3NBY, 3NBZ, 3NC0, 3NC1
Consensus CDS ProjectCCDS24475.1
International Mouse Knockout Project StatusXpo1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000005274 VEGA Gene Model | MGI Sequence Detail 42195 C57BL/6J ±  kb
transcript OTTMUST00000011750 VEGA | MGI Sequence Detail 6004 Not Applicable 
polypeptide OTTMUSP00000005444 VEGA | MGI Sequence Detail 1071 Not Applicable 

For the selected sequences
All sequences(74) RefSeq(10) UniProt(5)
Polymorphisms SNPs within 2kb(32 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR011989 Armadillo-like helical
InterPro IPR016024 Armadillo-type fold
InterPro IPR014877 CRM1 C-terminal domain
InterPro IPR013598 Exportin-1/Importin-beta-like
InterPro IPR001494 Importin-beta, N-terminal
Protein Ontology PR:000017497 exportin-1
References (Earliest) J:116366 Taagepera S, et al., Nuclear-cytoplasmic shuttling of C-ABL tyrosine kinase. Proc Natl Acad Sci U S A. 1998 Jun 23;95(13):7457-62
(Latest) J:193623 Monecke T, et al., Structural basis for cooperativity of CRM1 export complex formation. Proc Natl Acad Sci U S A. 2013 Jan 15;110(3):960-5
All references(59)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/23/2014
MGI 5.19
The Jackson Laboratory