Automated description from the Alliance of Genome Resources (Release 7.1.0)
Enables nuclear export signal receptor activity. Involved in mRNA export from nucleus and protein export from nucleus. Acts upstream of or within several processes, including protein localization to nucleus; regulation of centrosome duplication; and regulation of protein export from nucleus. Located in nucleus. Is expressed in several structures, including alimentary system; brain; early embryo; genitourinary system; and sensory organ. Human ortholog(s) of this gene implicated in colorectal cancer; gastric adenocarcinoma; hepatocellular carcinoma; and lung non-small cell carcinoma. Orthologous to human XPO1 (exportin 1).