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Chchd10 Gene Detail
Summary
  • Symbol
    Chchd10
  • Name
    coiled-coil-helix-coiled-coil-helix domain containing 10
  • Synonyms
    1620401E04Rik, Ndg2
  • Feature Type
    protein coding gene
  • IDs
    MGI:2143558
    NCBI Gene: 103172
  • Alliance
  • Transcription Start Sites
    9 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:75933130-75937747 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 10, 38.62 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    11 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2143558
protein coding gene Chr10:75932970-75937747 (.)
129S1/SvImJ MGP_129S1SvImJ_G0017372
protein coding gene Chr10:76137926-76140078 (+)
A/J MGP_AJ_G0017349
protein coding gene Chr10:73519106-73521258 (+)
AKR/J MGP_AKRJ_G0017310
protein coding gene Chr10:75493571-75495723 (+)
BALB/cJ MGP_BALBcJ_G0017309
protein coding gene Chr10:73716787-73718939 (+)
C3H/HeJ MGP_C3HHeJ_G0017133
protein coding gene Chr10:75541027-75543179 (+)
C57BL/6NJ MGP_C57BL6NJ_G0017767
protein coding gene Chr10:78830438-78832590 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0015457
protein coding gene Chr10:69970419-69972562 (+)
CAST/EiJ MGP_CASTEiJ_G0016704
protein coding gene Chr10:75856891-75859034 (+)
CBA/J MGP_CBAJ_G0017105
protein coding gene Chr10:81901731-81903883 (+)
DBA/2J MGP_DBA2J_G0017210
protein coding gene Chr10:72818773-72820925 (+)
FVB/NJ MGP_FVBNJ_G0017203
protein coding gene Chr10:71973584-71975736 (+)
LP/J MGP_LPJ_G0017283
protein coding gene Chr10:76638879-76641031 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0017231
protein coding gene Chr10:83994607-83996759 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0017806
protein coding gene Chr10:75528663-75530815 (+)
PWK/PhJ MGP_PWKPhJ_G0016487
protein coding gene Chr10:72647295-72649447 (+)
SPRET/EiJ MGP_SPRETEiJ_G0016270
protein coding gene Chr10:74780410-74782549 (+)
WSB/EiJ MGP_WSBEiJ_G0016767
protein coding gene Chr10:75510532-75512684 (+)



Homology
more
  • Human Ortholog
    CHCHD10, coiled-coil-helix-coiled-coil-helix domain containing 10
  • Vertebrate Orthologs
    9
  • Human Ortholog
    CHCHD10, coiled-coil-helix-coiled-coil-helix domain containing 10
    Orthology source: HomoloGene, HGNC
  • Synonyms
    C22orf16, FTDALS2, IMMD, MIX17A, N27C7-4, SMAJ
  • Links
    NCBI Gene ID: 400916
    neXtProt AC: NX_Q8WYQ3
    UniProt: Q8WYQ3

  • Chr Location
    22q11.23; chr22:23765834-23767972 (-)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with human CHCHD10 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    3 phenotypes from 1 allele in 1 genetic background
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous deletion results in mild mitochondrial respiration anomalies in skeletal muscle.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000049422 Ensembl Gene Model | MGI Sequence Detail 4618 C57BL/6J ±  kb
    transcript ENSMUST00000219839 Ensembl | MGI Sequence Detail 1488 Not Applicable  
    polypeptide ENSMUSP00000151675 Ensembl | MGI Sequence Detail 138 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      3 Sequences
    • InterPro Domains
    Molecular
    Reagents
    less
    • All nucleic 12
      cDNA 11
      Primer pair 1

      Microarray probesets 3
    References
    more
    • Summaries
      All 40
      Developmental Gene Expression 4
      Gene Ontology 6
      Phenotypes 10
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:254726 Burstein SR, et al., In vitro and in vivo studies of the ALS-FTLD protein CHCHD10 reveal novel mitochondrial topology and protein interactions. Hum Mol Genet. 2018 Jan 1;27(1):160-177

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory