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Chchd10 Gene Detail
Summary
  • Symbol
    Chchd10
  • Name
    coiled-coil-helix-coiled-coil-helix domain containing 10
  • Synonyms
    1620401E04Rik, Ndg2
  • Feature Type
    protein coding gene
  • IDs
    MGI:2143558
    NCBI Gene: 103172
Location & Maps
more
  • Sequence Map
    Chr10:75935573-75937725 bp, + strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      2153 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 10, 38.62 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    CHCHD10, coiled-coil-helix-coiled-coil-helix domain containing 10
  • Vertebrate Orthologs
    9
  • Human Ortholog
    CHCHD10, coiled-coil-helix-coiled-coil-helix domain containing 10
    Orthology source: HomoloGene
  • Synonyms
    C22orf16, FTDALS2, IMMD, N27C7-4, SMAJ
  • Links
    NCBI Gene ID: 400916
    neXtProt AC: NX_Q8WYQ3

  • Chr Location
    22q11.23; chr22:23765834-23767972 (-)  GRCh38.p2

Human Diseases
more
  • Diseases
    3 with human CHCHD10 associations

Human Disease Mouse Models
       Frontotemporal Dementia and/or Amyotrophic Lateral Sclerosis 2; FTDALS2   OMIM: 615911
Myopathy, Isolated Mitochondrial, Autosomal Dominant; IMMD   OMIM: 616209
Spinal Muscular Atrophy, Jokela Type; SMAJ   OMIM: 615048
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    8 phenotype references
  • All Mutations and Alleles
    10
  • Chemically induced (other)
    1
  • Gene trapped
    8
  • Targeted
    1
  • Genomic Mutations
    1 involving Chchd10
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000049422 Ensembl Gene Model | MGI Sequence Detail 2153 C57BL/6J ±  kb
transcript ENSMUST00000058906 Ensembl | MGI Sequence Detail 939 Not Applicable  
polypeptide ENSMUSP00000059575 Ensembl | MGI Sequence Detail 138 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    11 from dbSNP Build 142
Protein
Information
less
  • UniProt
    3 Sequences
  • InterPro Domains
Molecular
Reagents
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  • All nucleic 10
    cDNA 9
    Primer pair 1

    Microarray probesets 3
References
more
  • Summaries
    All 29
    Developmental Gene Expression 4
    Gene Ontology 3
    Phenotypes 8
  • Earliest
    J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
  • Latest
    J:174767 Tang F, et al., Deterministic and stochastic allele specific gene expression in single mouse blastomeres. PLoS One. 2011;6(6):e21208

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/22/2016
MGI 6.04
The Jackson Laboratory