About   Help   FAQ
Lrrk1 Gene Detail
Summary
  • Symbol
    Lrrk1
  • Name
    leucine-rich repeat kinase 1
  • Synonyms
    C230002E15Rik, D130026O16Rik, mKIAA1790
  • Feature Type
    protein coding gene
  • IDs
    MGI:2142227
    NCBI Gene: 233328
  • Gene Overview
    MyGene.info: LRRK1
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr7:66226912-66388350 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      161439 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 7, 35.57 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    LRRK1, leucine rich repeat kinase 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    LRRK1, leucine rich repeat kinase 1
    Orthology source: HGNC, HomoloGene
  • Synonyms
    RIPK6, Roco1
  • Links
    NCBI Gene ID: 79705
    neXtProt AC: NX_Q38SD2
    UniProt: Q38SD2

  • Chr Location
    15q26.3; chr15:100919017-101070837 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 23464
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: LRRK1
  • Gene Tree
Human Diseases
more
  • Diseases
    1 with Lrrk1 mouse models

Human Disease Mouse Models
      
IDs
View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    54 phenotypes from 3 alleles in 3 genetic backgrounds
    25 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit preweaning lethality. Mice homozygous for another knock-out allele exhibit severe osteopetrosis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000024885 VEGA Gene Model | MGI Sequence Detail 161439 C57BL/6J ±  kb
    transcript OTTMUST00000061293 VEGA | MGI Sequence Detail 7465 Not Applicable  
    polypeptide OTTMUSP00000030034 VEGA | MGI Sequence Detail 2014 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      2549 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 65
      cDNA 63
      Primer pair 1
      Other 1

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:2442577, MGI:2442723
    References
    more
    • Summaries
      All 55
      Developmental Gene Expression 3
      Diseases 1
      Gene Ontology 5
      Phenotypes 25
    • Earliest
      J:88307 Giometti CS, et al., The analysis of recessive lethal mutations in mice by using two-dimensional gel electrophoresis of liver proteins. Mutat Res. 1990 Sep;242(1):47-55
    • Latest
      J:243749 Giaime E, et al., Age-Dependent Dopaminergic Neurodegeneration and Impairment of the Autophagy-Lysosomal Pathway in LRRK-Deficient Mice. Neuron. 2017 Nov 15;96(4):796-807.e6

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
    Warranty Disclaimer & Copyright Notice
    Send questions and comments to User Support.
    last database update
    09/11/2018
    MGI 6.12
    The Jackson Laboratory