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Lrrk1 Gene Detail
Summary
  • Symbol
    Lrrk1
  • Name
    leucine-rich repeat kinase 1
  • Synonyms
    C230002E15Rik, D130026O16Rik, mKIAA1790
  • Feature Type
    protein coding gene
  • IDs
    MGI:2142227
    NCBI Gene: 233328
Location & Maps
more
  • Sequence Map
    Chr7:66226912-66388350 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      161439 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    LRRK1, leucine-rich repeat kinase 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    LRRK1, leucine-rich repeat kinase 1
    Orthology source: HGNC, HomoloGene
  • Synonyms
    RIPK6, Roco1
  • Links
    NCBI Gene ID: 79705
    neXtProt AC: NX_Q38SD2

  • Chr Location
    15q26.3; chr15:100919215-101070112 (+)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 23464
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 western clawed frog;1 zebrafish
  • HCOP
    human homology predictions: LRRK1
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    25 phenotypes from 2 alleles in 2 genetic backgrounds
    20 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    11
  • Chemically induced (other)
    1
  • Gene trapped
    2
  • Radiation induced
    1
  • Targeted
    7
  • Genomic Mutations
    2 involving Lrrk1
  • Incidental Mutations
Mice homozygous for a knock-out allele exhibit preweaning lethality. Mice homozygous for another knock-out allele exhibit severe osteopetrosis.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000024885 VEGA Gene Model | MGI Sequence Detail 161439 C57BL/6J ±  kb
transcript OTTMUST00000061293 VEGA | MGI Sequence Detail 7465 Not Applicable  
polypeptide OTTMUSP00000030034 VEGA | MGI Sequence Detail 2014 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    2581 from dbSNP Build 137
Protein
Information
less
Molecular
Reagents
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  • All nucleic 63
    cDNA 61
    Primer pair 1
    Other 1

    Microarray probesets 5
Other
Accession IDs
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MGI:2442577, MGI:2442723
References
more
  • Summaries
    All 39
    Developmental Gene Expression 3
    Gene Ontology 4
    Phenotypes 20
  • Earliest
    J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
  • Latest
    J:217812 Peng H, et al., FIH-1 disrupts an LRRK1/EGFR complex to positively regulate keratinocyte migration. Am J Pathol. 2014 Dec;184(12):3262-71

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory