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Lrrk1
Gene Detail
 Symbol
Name
ID
Lrrk1
leucine-rich repeat kinase 1
MGI:2142227
Synonyms C230002E15Rik, D130026O16Rik, mKIAA1790
Feature Type protein coding gene
Genetic Map
Chromosome 7
35.57 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr7:66226912-66388350 bp, - strand
From VEGA annotation of GRCm38

  161439 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:23464  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Lrrk1

Human
homologs
Human Homolog LRRK1, leucine-rich repeat kinase 1
NCBI Gene ID 79705
neXtProt AC  NX_Q38SD2
Human Synonyms  RIPK6, Roco1
Human Chr (Location)  15q26.3; chr15:100919255-101070112 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(7) : Gene trapped(2) Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele exhibit preweaning lethality. Mice homozygous for another knock-out allele exhibit severe osteopetrosis.
 
Interactions
Lrrk1 interacts with 244 markers (Mir9-1, Mir9-2, Mir9-3, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (25 annotations)
Process bone resorption, negative regulation of peptidyl-tyrosine phosphorylation, ...
Component cytoplasm, intracellular, ...
Function ATP binding, GTP binding, ...
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (38)    Tissues (33)    Images (6)
Theiler Stages: 19, 21, 23, 25, 26, 28
Assay TypeResults
Northern blot 18
RT-PCR 20
cDNA source data(61)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(63) cDNA(61) Primer pair(1) Other(1)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000024885 (Evidence)
Ensembl Gene ModelENSMUSG00000015133 (Evidence)
Entrez Gene233328 (Evidence)
UniGene33284
DFCITC1578302, TC1585145, TC1602497, TC1604752, TC1616450
DoTSDT.101290048, DT.101366803, DT.101735738, DT.55223345, DT.97406865, DT.99591061
NIA Mouse Gene IndexU028682
EC2.7.11.1
Consensus CDS ProjectCCDS21344.1
International Mouse Knockout Project StatusLrrk1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000024885 VEGA Gene Model | MGI Sequence Detail 161439 C57BL/6J ±  kb
transcript OTTMUST00000061293 VEGA | MGI Sequence Detail 7465 Not Applicable 
polypeptide OTTMUSP00000030034 VEGA | MGI Sequence Detail 2014 Not Applicable 

For the selected sequences
All sequences(66) RefSeq(11) UniProt(3)
Polymorphisms SNPs within 2kb(2581 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR002110 Ankyrin repeat
InterPro IPR020683 Ankyrin repeat-containing domain
InterPro IPR001611 Leucine-rich repeat
InterPro IPR025875 Leucine rich repeat 4
InterPro IPR003591 Leucine-rich repeat, typical subtype
InterPro IPR013684 Mitochondrial Rho-like
InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
InterPro IPR000719 Protein kinase, catalytic domain
InterPro IPR011009 Protein kinase-like domain
InterPro IPR011044 Quinoprotein amine dehydrogenase, beta chain-like
InterPro IPR020859 ROC GTPase
Protein Ontology PR:000029122 leucine-rich repeat serine/threonine-protein kinase 1
References (Earliest) J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
(Latest) J:208677 Xing W, et al., Targeted disruption of leucine-rich repeat kinase 1 but not leucine-rich repeat kinase 2 in mice causes severe osteopetrosis. J Bone Miner Res. 2013 Sep;28(9):1962-74
All references(40)
Other
accession IDs
MGI:2442577, MGI:2442723

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/12/2014
MGI 5.19
The Jackson Laboratory