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Symbol
Name
ID

Lrrk1
leucine-rich repeat kinase 1
MGI:2142227

Phenotype annotations related to skeleton

*	Aspects of the system are reported to show a normal phenotype.
	Darker colors indicate more annotations

Human Phenotypes	Dense metaphyseal bands	Metaphyseal dysplasia	Clavicular sclerosis	Sclerotic vertebral endplates	Increased bone mineral density
Disease(s) Associated with LRRK1
osteosclerotic metaphyseal dysplasia

Mouse Phenotypes

skeleton phenotype

abnormal tooth morphology

absent teeth

abnormal mandible morphology

abnormal maxilla morphology

abnormal zygomatic bone morphology

increased osteoclast cell number

abnormal osteoclast physiology

abnormal humerus morphology

abnormal radius morphology

abnormal ulna morphology

abnormal femur morphology

short femur

abnormal fibula morphology

abnormal tibia morphology

short tibia

abnormal long bone morphology

abnormal clavicle morphology

abnormal long bone metaphysis morphology

abnormal pelvic girdle bone morphology

small pubis

abnormal rib morphology

abnormal vertebrae morphology

abnormal bone marrow cavity morphology

increased bone mineral content

increased bone mineral density

increased trabecular bone volume

increased compact bone thickness

decreased susceptibility to osteoporosis

abnormal trabecular bone morphology

increased bone trabecula number

increased trabecular bone thickness

osteopetrosis

osteosclerosis

abnormal joint morphology

abnormal bone mineralization

decreased bone resorption

Availability

Mouse Genotype

Lrrk1^m1Btlr/Lrrk1^m1Btlr

Lrrk1^tm1.1Smo/Lrrk1^tm1.1Smo

*

Lrrk1^{tm1b(KOMP)Wtsi}/Lrrk1^{tm1b(KOMP)Wtsi}

Lrrk1^M2Btlr/Lrrk1⁺

*

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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