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H6pd
Gene Detail
Symbol

Name
ID
H6pd
hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase)
MGI:2140356
Synonyms
G6pd1, Gpd1, Gpd-1
Feature Type
protein coding gene
Genetic Map
Chromosome 4
80.65 cM
Detailed Genetic Map ± 1 cM


Mapping data(95)
Sequence Map
Chr4:149979475-150009023 bp, - strand
From VEGA annotation of GRCm38

  29549 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:48275  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: H6PD
Gene Tree: H6pd

Human
homologs
H6PD, hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase)
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 9563
neXtProt AC: NX_O95479

Human Synonyms: CORTRD1, G6PDH, GDH

Human Chr (Location): 1p36; chr1:9234776-9271337 (+)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human H6PD

Mutations,
alleles, and
phenotypes
All mutations/alleles(17) : Gene trapped(13) Targeted(4)
Genomic Mutations involving H6pd (1)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele show enlarged adrenal glands, reduced plasma corticosterone levels and altered 11 beta-hydroxysteroid dehydrogenase type 1 enzyme activity. Treatment with 11-dehydrocorticosterone fails to inhibit glucose-stimulated insulin secretion in pancreatic islets.
 
Interactions
H6pd interacts with 221 markers (Mir7-2, Mir7b, Mir9-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (20 annotations)
Process carbohydrate metabolic process, glucose metabolic process, ...
Component cytoplasm, endoplasmic reticulum, ...
Function 6-phosphogluconolactonase activity, carbohydrate binding, ...
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (118)    Tissues (109)    Images (5)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 118
cDNA source data(94)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase h6pd    NEW 
Molecular
reagents
All nucleic(95) cDNA(94) Primer pair(1)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000010275 (Evidence)
Ensembl Gene Model ENSMUSG00000028980 (Evidence)
Entrez Gene 100198 (Evidence)
UniGene 22183
DFCI TC1574811, TC1605844
DoTS DT.101279091, DT.110831958, DT.493574, DT.94236797
NIA Mouse Gene Index U025814, U109864
EC 1.1.1.47, 3.1.1.31
Consensus CDS Project CCDS18967.1, CCDS71524.1
International Mouse Phenotyping Consortium Status H6pd
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000010275 VEGA Gene Model | MGI Sequence Detail 29549 C57BL/6J ±  kb
transcript OTTMUST00000023908 VEGA | MGI Sequence Detail 4745 Not Applicable 
polypeptide OTTMUSP00000010964 VEGA | MGI Sequence Detail 797 Not Applicable 

For the selected sequences
All sequences(67) RefSeq(16) UniProt(6)
Polymorphisms
SNPs within 2kb(192 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR005900 6-phosphogluconolactonase, DevB-type
InterPro IPR006148 Glucosamine/galactosamine-6-phosphate isomerase
InterPro IPR001282 Glucose-6-phosphate dehydrogenase
InterPro IPR019796 Glucose-6-phosphate dehydrogenase, active site
InterPro IPR022675 Glucose-6-phosphate dehydrogenase, C-terminal
InterPro IPR022674 Glucose-6-phosphate dehydrogenase, NAD-binding
InterPro IPR016040 NAD(P)-binding domain
Protein Ontology PR:000008426 GDH/6PGL endoplasmic bifunctional protein
References
(Earliest) J:5135 Hutton JJ, et al., Linkage analyses using biochemical variants in mice. II. Levulinate dehydratase and autosomal glucose 6-phosphate dehydrogenase. Biochem Genet. 1969 Oct;3(5):517-23
(Latest) J:204054 Soulier A, et al., Cell-intrinsic regulation of murine dendritic cell function and survival by prereceptor amplification of glucocorticoid. Blood. 2013 Nov 7;122(19):3288-97
All references(111)
Other
accession IDs
MGD-MRK-10221, MGD-MRK-10223, MGD-MRK-33658, MGI:105978

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/18/2015
MGI 6.0
The Jackson Laboratory