H6pd
Gene Detail

Symbol

Name
ID

H6pd
hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase)
MGI:2140356

Synonyms

G6pd1, Gpd1, Gpd-1

Feature Type

protein coding gene

Genetic Map

Chromosome 4
80.65 cM
Detailed Genetic Map ± 1 cM


Mapping data(95)

Sequence Map

Chr4:149979475-150009023 bp, - strand From VEGA annotation of GRCm38   29549 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate
homology

HomoloGene:48275  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: H6pd

Human
homologs

Human Homolog		H6PD, hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase)
NCBI Gene ID		9563
neXtProt AC		NX_O95479
Human Synonyms		CORTRD1, G6PDH, GDH
Human Chr (Location)		1p36; chr1:9234764-9271337 (+)  GRCh38
Disease Associations		(1) Diseases Associated with Human H6PD

Mutations,
alleles, and
phenotypes

All mutations/alleles(17) : Gene trapped(13) Targeted(4)
Genomic Mutations involving H6pd (1)
Incidental mutations (data from Mutagenetix , APF )
 

Mice homozygous for a knock-out allele show enlarged adrenal glands, reduced plasma corticosterone levels and altered 11 beta-hydroxysteroid dehydrogenase type 1 enzyme activity. Treatment with 11-dehydrocorticosterone fails to inhibit glucose-stimulated insulin secretion in pancreatic islets.

 

Interactions

H6pd interacts with 222 markers (Mir7-2, Mir7b, Mir9-1, ...)

View All

Gene Ontology
(GO)
classifications

All GO classifications: (20 annotations)

Process	carbohydrate metabolic process, glucose metabolic process, ...
Component	cytoplasm, endoplasmic reticulum, ...
Function	6-phosphogluconolactonase activity, carbohydrate binding, ...

External Resources: FuncBase

Expression

Literature Summary: (2 records)

Data Summary: Results (118)    Tissues (109)    Images (5)    Tissue x Stage Matrix (view)

Assay Type	Results
RNA in situ	118

cDNA source data(94)
External Resources: Allen Institute   GEO   Expression Atlas

Molecular
reagents

All nucleic(95) cDNA(94) Primer pair(1)
Microarray probesets(3)

Other database
links

VEGA Gene Model	OTTMUSG00000010275 (Evidence)
Ensembl Gene Model	ENSMUSG00000028980 (Evidence)
Entrez Gene	100198 (Evidence)
UniGene	22183
DFCI	TC1605844, TC1574811
DoTS	DT.101279091, DT.110831958, DT.94236797, DT.493574
NIA Mouse Gene Index	U025814, U109864
EC	1.1.1.47, 3.1.1.31
Consensus CDS Project	CCDS18967.1, CCDS71524.1
International Mouse Knockout Project Status	H6pd

Sequences

Length	Strain/Species
genomic	OTTMUSG00000010275	VEGA Gene Model | MGI Sequence Detail	29549	C57BL/6J
transcript	OTTMUST00000023908	VEGA | MGI Sequence Detail	4745	Not Applicable
polypeptide	OTTMUSP00000010964	VEGA | MGI Sequence Detail	797	Not Applicable

All sequences(74) RefSeq(18) UniProt(11)

Polymorphisms

SNPs within 2kb(192 from dbSNP Build 137)

Protein-related
information

Resource	ID	Description
InterPro	IPR005900	6-phosphogluconolactonase, DevB-type
InterPro	IPR006148	Glucosamine/galactosamine-6-phosphate isomerase
InterPro	IPR001282	Glucose-6-phosphate dehydrogenase
InterPro	IPR019796	Glucose-6-phosphate dehydrogenase, active site
InterPro	IPR022675	Glucose-6-phosphate dehydrogenase, C-terminal
InterPro	IPR022674	Glucose-6-phosphate dehydrogenase, NAD-binding
InterPro	IPR016040	NAD(P)-binding domain
Protein Ontology	PR:000008426	GDH/6PGL endoplasmic bifunctional protein

References

(Earliest) J:5135 Hutton JJ, et al., Linkage analyses using biochemical variants in mice. II. Levulinate dehydratase and autosomal glucose 6-phosphate dehydrogenase. Biochem Genet. 1969 Oct;3(5):517-23
(Latest) J:204054 Soulier A, et al., Cell-intrinsic regulation of murine dendritic cell function and survival by prereceptor amplification of glucocorticoid. Blood. 2013 Nov 7;122(19):3288-97
All references(113)

Other
accession IDs

MGD-MRK-10221, MGD-MRK-10223, MGD-MRK-33658, MGI:105978