H6pd Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

H6pd
hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase)
MGI:2140356

28 phenotypes from 3 alleles in 4 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
H6pd^{tm1a(EUCOMM)Wtsi}/H6pd^{tm1a(EUCOMM)Wtsi} C57BL/6N-H6pd^{tm1a(EUCOMM)Wtsi}/Ics	decreased body weight	J:165965
H6pd^{tm1c(EUCOMM)Wtsi}/H6pd^{tm1c(EUCOMM)Wtsi} Tg(Adipoq-cre)1Evdr/0 involves: C57BL/6N * FVB/NJ	abnormal corticosterone level	J:292236
	normal behavior/neurological phenotype	J:292236
	normal cardiovascular system phenotype	J:292236
	decreased circulating free fatty acids level	J:292236
	decreased circulating insulin level	J:292236
	decreased epididymal fat pad weight	J:292236
	decreased fasting circulating glucose level	J:292236
	decreased fat cell size	J:292236
	decreased lipogenesis	J:292236
	decreased mesenteric fat pad weight	J:292236
	decreased subcutaneous adipose tissue amount	J:292236
	normal growth/size/body region phenotype	J:292236
	impaired lipolysis	J:292236
	improved glucose tolerance	J:292236
	increased insulin sensitivity	J:292236
H6pd^tm1Pmst/H6pd^tm1Pmst involves: 129P2/OlaHsd	abnormal enzyme/coenzyme activity	J:141273
H6pd^tm1Pmst/H6pd^tm1Pmst involves: 129P2/OlaHsd	abnormal response/metabolism to endogenous compounds	J:141273
H6pd^tm1Pmst/H6pd^tm1Pmst involves: 129P2/OlaHsd * C57BL/6	abnormal enzyme/coenzyme activity	J:108281
	abnormal skeletal muscle fiber morphology	J:189132
	centrally nucleated skeletal muscle fibers	J:189132
	decreased body weight	J:189132
	decreased circulating corticosterone level	J:108281, J:189132
	decreased circulating glucose level	J:189132
	decreased lean body mass	J:189132
	decreased quadriceps weight	J:189132
	decreased tibialis anterior weight	J:189132
	enlarged adrenal glands	J:108281, J:189132
	increased skeletal muscle glycogen level	J:189132
	skeletal muscle atrophy	J:189132

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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