Sall4
Gene Detail

Symbol Name ID

Sall4 sal-like 4 (Drosophila) MGI:2139360

Synonyms

5730441M18Rik, C330011P20Rik, Tex20

Feature Type

protein coding gene

Genetic Map

Chromosome 2

88.99 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)

Sequence Map

Chr2:168748332-168767943 bp, - strand From VEGA annotation of GRCm38   19612 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:10716  Vertebrate Homology Class
1 human; 1 mouse; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Sall4

Human homologs

Human Homolog		SALL4, sal-like 4 (Drosophila)
NCBI Gene ID		57167
neXtProt AC		NX_Q9UJQ4
Human Synonyms		dJ1112F19.1, DRRS, HSAL4, ZNF797
Human Chr (Location)		20q13.2; chr20:50400581-50419048 (-)  GRCh37.p10
Disease Associations		(2) Diseases Associated with Human SALL4

Alleles and phenotypes

All alleles(237) : Targeted(11) Gene trapped(226)
 

Homozygous mutation of this gene results in early embryonic lethality before somite formation. Heterozygous mutation of this locus causes variable phenotypes, from heart and digit defects to deafness, anogenital tract defects, cranial and carpal bone defects and renal agenesis or hypoplasia.

 
Human Diseases Modeled Using Mouse Sall4 (2)    Alleles Annotated to Human Diseases(3)    Phenotype Images(2)

Gene Ontology (GO) classifications

All GO classifications: (28 annotations)

Process	embryonic limb morphogenesis, heart development, ...
Component	heterochromatin, nucleus, ...
Function	DNA binding, metal ion binding, ...

External Resources: FuncBase

Expression

Literature Summary: (22 records)
Data Summary: Results (205)    Tissues (123)    Images (17)
Theiler Stages: 2, 3, 4, 5, 11, 13, 14, 15, 17, 19, 20, 23, 28

Assay Type	Results
RNA in situ	122
In situ reporter (knock in)	10
Northern blot	9
RT-PCR	64

cDNA source data(20)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(23) cDNA(20) Primer pair(3)
Microarray probesets(5)

Other database links

VEGA Gene Model	OTTMUSG00000016116 (Evidence)
Ensembl Gene Model	ENSMUSG00000027547 (Evidence)
Entrez Gene	99377 (Evidence)
DFCI	TC1578482, TC1579259
DoTS	DT.102552071, DT.110652882, DT.531333
NIA Mouse Gene Index	U023697
Consensus CDS Project	CCDS17115.1, CCDS17116.1, CCDS17117.1
International Mouse Knockout Project Status	Sall4

Sequences

Length	Strain/Species
genomic	OTTMUSG00000016116	VEGA Gene Model | MGI Sequence Detail	19612	C57BL/6J
transcript	OTTMUST00000038511	VEGA | MGI Sequence Detail	5073	Not Applicable
polypeptide	OTTMUSP00000017238	VEGA | MGI Sequence Detail	1067	Not Applicable

All sequences(72) RefSeq(6) UniProt(8)

Polymorphisms

SNPs(62 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR007087	Zinc finger, C2H2
InterPro	IPR015880	Zinc finger, C2H2-like
InterPro	IPR013087	Zinc finger C2H2-type/integrase DNA-binding domain
Protein Ontology	PR:000014439	Sal-like protein 4

References

(Earliest) J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
(Latest) J:185669 Hobbs RM, et al., Functional antagonism between Sall4 and Plzf defines germline progenitors. Cell Stem Cell. 2012 Mar 2;10(3):284-98
All references(70)

Other accession IDs

MGI:1922958, MGI:2138745, MGI:2139124, MGI:2139468, MGI:2139473