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Sall4
Gene Detail
Symbol

Name
ID
Sall4
sal-like 4 (Drosophila)
MGI:2139360
Synonyms
5730441M18Rik, C330011P20Rik, Tex20
Feature Type
protein coding gene
Genetic Map
Chromosome 2
88.99 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr2:168748332-168767943 bp, - strand
From VEGA annotation of GRCm38

  19612 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:10716  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: SALL4
Gene Tree: Sall4

Human
homologs
SALL4, spalt-like transcription factor 4
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 57167
neXtProt AC: NX_Q9UJQ4

Human Synonyms: dJ1112F19.1, DRRS, HSAL4, ZNF797

Human Chr (Location): 20q13.2; chr20:51784009-51913245 (-)  GRCh38.p2

Disease Associations: (2) Diseases Associated with Human SALL4

Mutations,
alleles, and
phenotypes
All mutations/alleles(238) : Gene trapped(226) Targeted(11) Transgenic(1)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Homozygous mutation of this gene results in early embryonic lethality before somite formation. Heterozygous mutation of this locus causes variable phenotypes, from heart and digit defects to deafness, anogenital tract defects, cranial and carpal bone defects and renal agenesis or hypoplasia.
 
Human Diseases Modeled in Mice Using Sall4 (2)    Mutations Annotated to Human Diseases (4)    Phenotype Images(2)
Interactions
Sall4 interacts with 226 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (32 annotations)
Process embryonic limb morphogenesis, heart development, ...
Component cytoplasm, heterochromatin, ...
Function DNA binding, metal ion binding, ...
External Resources: FuncBase
Expression
Literature Summary: (32 records)
Data Summary: Results (198)    Tissues (121)    Images (17)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 122
In situ reporter (knock in) 10
Northern blot 9
RT-PCR 57
cDNA source data(21)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: GEISHA SALL4 ; Xenbase sall4 ; ZFIN sall4    NEW 
Molecular
reagents
All nucleic(24) cDNA(21) Primer pair(3)
Microarray probesets(5)
Other database
links
VEGA Gene Model OTTMUSG00000016116 (Evidence)
Ensembl Gene Model ENSMUSG00000027547 (Evidence)
Entrez Gene 99377 (Evidence)
DFCI TC1579259, TC1578482
DoTS DT.531333, DT.110652882, DT.102552071
NIA Mouse Gene Index U023697
Consensus CDS Project CCDS17115.1, CCDS17116.1, CCDS17117.1
International Mouse Phenotyping Consortium Status Sall4
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000016116 VEGA Gene Model | MGI Sequence Detail 19612 C57BL/6J ±  kb
transcript OTTMUST00000038511 VEGA | MGI Sequence Detail 5073 Not Applicable 
polypeptide OTTMUSP00000017238 VEGA | MGI Sequence Detail 1067 Not Applicable 

For the selected sequences
All sequences(73) RefSeq(8) UniProt(6)
Polymorphisms
SNPs within 2kb(94 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR007087 Zinc finger, C2H2
InterPro IPR015880 Zinc finger, C2H2-like
InterPro IPR013087 Zinc finger C2H2-type/integrase DNA-binding domain
Protein Ontology PR:000014439 Sal-like protein 4
References
(Earliest) J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
(Latest) J:220960 Akiyama R, et al., Sall4-Gli3 system in early limb progenitors is essential for the development of limb skeletal elements. Proc Natl Acad Sci U S A. 2015 Apr 21;112(16):5075-80
All references(83)
Disease annotation references (3)
Other
accession IDs
MGI:1922958, MGI:2138745, MGI:2139124, MGI:2139468, MGI:2139473

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory