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Sall4
Gene Detail
 Symbol
Name
ID
Sall4
sal-like 4 (Drosophila)
MGI:2139360
Synonyms 5730441M18Rik, C330011P20Rik, Tex20
Feature Type protein coding gene
Genetic Map
Chromosome 2
88.99 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr2:168748332-168767943 bp, - strand
From VEGA annotation of GRCm38

  19612 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:10716  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Sall4

Human
homologs
Human Homolog SALL4, spalt-like transcription factor 4
NCBI Gene ID 57167
neXtProt AC  NX_Q9UJQ4
Human Synonyms  dJ1112F19.1, DRRS, HSAL4, ZNF797
Human Chr (Location)  20q13.2; chr20:51784012-51802509 (-)  GRCh38
Disease Associations  (2) Diseases Associated with Human SALL4
Mutations,
alleles, and
phenotypes
All mutations/alleles(237) : Gene trapped(226) Targeted(11)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous mutation of this gene results in early embryonic lethality before somite formation. Heterozygous mutation of this locus causes variable phenotypes, from heart and digit defects to deafness, anogenital tract defects, cranial and carpal bone defects and renal agenesis or hypoplasia.
 
Human Diseases Modeled Using Mouse Sall4 (2)    Alleles Annotated to Human Diseases(3)    Phenotype Images(2)
Interactions
Sall4 interacts with 226 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (30 annotations)
Process embryonic limb morphogenesis, heart development, ...
Component cytoplasm, heterochromatin, ...
Function DNA binding, metal ion binding, ...
External Resources: FuncBase
Expression
Literature Summary: (26 records)
Data Summary: Results (205)    Tissues (123)    Images (17)
Theiler Stages: 2, 3, 4, 5, 11, 13, 14, 15, 17, 19, 20, 23, 28
Assay TypeResults
RNA in situ 122
In situ reporter (knock in) 10
Northern blot 9
RT-PCR 64
cDNA source data(20)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(23) cDNA(20) Primer pair(3)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000016116 (Evidence)
Ensembl Gene ModelENSMUSG00000027547 (Evidence)
Entrez Gene99377 (Evidence)
DFCITC1578482, TC1579259
DoTSDT.102552071, DT.110652882, DT.531333
NIA Mouse Gene IndexU023697
Consensus CDS ProjectCCDS17115.1, CCDS17116.1, CCDS17117.1
International Mouse Knockout Project StatusSall4
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000016116 VEGA Gene Model | MGI Sequence Detail 19612 C57BL/6J ±  kb
transcript OTTMUST00000038511 VEGA | MGI Sequence Detail 5073 Not Applicable 
polypeptide OTTMUSP00000017238 VEGA | MGI Sequence Detail 1067 Not Applicable 

For the selected sequences
All sequences(72) RefSeq(8) UniProt(6)
Polymorphisms SNPs within 2kb(94 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR007087 Zinc finger, C2H2
InterPro IPR015880 Zinc finger, C2H2-like
InterPro IPR013087 Zinc finger C2H2-type/integrase DNA-binding domain
Protein Ontology PR:000014439 Sal-like protein 4
References (Earliest) J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
(Latest) J:205047 Liu L, et al., Histone lysine-specific demethylase 1 (LSD1) protein is involved in Sal-like protein 4 (SALL4)-mediated transcriptional repression in hematopoietic stem cells. J Biol Chem. 2013 Nov 29;288(48):34719-28
All references(77)
Disease annotation references (3)
Other
accession IDs
MGI:1922958, MGI:2138745, MGI:2139124, MGI:2139468, MGI:2139473

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/23/2014
MGI 5.19
The Jackson Laboratory