Automated description from the Alliance of Genome Resources (Release 7.0.0)
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within several processes, including chordate embryonic development; embryonic limb morphogenesis; and regulation of transcription by RNA polymerase II. Located in nucleus. Part of heterochromatin. Is expressed in several structures, including central nervous system; early conceptus; embryo mesenchyme; reproductive system; and sensory organ. Used to study Duane-radial ray syndrome and otitis media. Human ortholog(s) of this gene implicated in Duane retraction syndrome; Duane-radial ray syndrome; Holt-Oram syndrome; IVIC syndrome; and ventricular septal defect. Orthologous to human SALL4 (spalt like transcription factor 4).