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Myocd Gene Detail
Summary
  • Symbol
    Myocd
  • Name
    myocardin
  • Synonyms
    Srfcp
  • Feature Type
    protein coding gene
  • IDs
    MGI:2137495
    NCBI Gene: 214384
  • Gene Overview
    MyGene.info: MYOCD
Location & Maps
more
  • Sequence Map
    Chr11:65176561-65269941 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      93381 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    MYOCD, myocardin
  • Vertebrate Orthologs
    10
  • Human Ortholog
    MYOCD, myocardin
    Orthology source: HGNC, HomoloGene
  • Synonyms
    MYCD
  • Links
    NCBI Gene ID: 93649
    neXtProt AC: NX_Q8IZQ8

  • Chr Location
    17p11.2; chr17:12665890-12768949 (+)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with Myocd mouse models

Human Disease Mouse Models
       Patent Ductus Arteriosus   OMIM: 607411 View 2 models
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    16 phenotypes from 5 alleles in 6 genetic backgrounds
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    9
  • Chemically induced (other)
    1
  • Targeted
    8
  • Genomic Mutations
    1 involving Myocd
  • Incidental Mutations
Mice homozygous for a null mutation exhibit embryonic lethality and fail to form vascular smooth muscle.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000005903 VEGA Gene Model | MGI Sequence Detail 93381 C57BL/6J ±  kb
transcript OTTMUST00000013135 VEGA | MGI Sequence Detail 4935 Not Applicable  
polypeptide OTTMUSP00000006096 VEGA | MGI Sequence Detail 935 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    870 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 22
    Genomic 1
    cDNA 15
    Primer pair 5
    Other 1

    Microarray probesets 4
References
more
  • Summaries
    All 93
    Developmental Gene Expression 46
    Diseases 1
    Gene Ontology 24
    Phenotypes 15
  • Earliest
    J:70265 Wang D, et al., Activation of cardiac gene expression by myocardin, a transcriptional cofactor for serum response factor. Cell. 2001 Jun 29;105(7):851-62
  • Latest
    J:227639 Baeten JT, et al., Loss of Notch2 and Notch3 in vascular smooth muscle causes patent ductus arteriosus. Genesis. 2015 Dec;53(12):738-48

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
04/19/2016
MGI 6.03
The Jackson Laboratory