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Myocd
Gene Detail
Symbol

Name
ID
Myocd
myocardin
MGI:2137495
Synonyms
Srfcp
Feature Type
protein coding gene
Genetic Map
Chromosome 11
40.42 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr11:65176561-65269941 bp, - strand
From VEGA annotation of GRCm38

  93381 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:17043  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: MYOCD
Protein SuperFamily: MKL/myocardin-like protein
Gene Tree: Myocd

Human
homologs
MYOCD, myocardin
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 93649
neXtProt AC: NX_Q8IZQ8

Human Synonyms: MYCD

Human Chr (Location): 17p11.2; chr17:12665890-12768949 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(8) : Targeted(8)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a null mutation exhibit embryonic lethality and fail to form vascular smooth muscle.
 
Human Diseases Modeled in Mice Using Myocd (1)    Mutations Annotated to Human Diseases (1)   
Interactions
Myocd interacts with 283 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (44 records)
Data Summary: Results (59)    Tissues (26)    Images (12)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 12
In situ reporter (knock in) 16
RT-PCR 31
cDNA source data(15)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase myocd    NEW 
Molecular
reagents
All nucleic(22) Genomic(1) cDNA(15) Primer pair(5) Other(1)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000005903 (Evidence)
Ensembl Gene Model ENSMUSG00000020542 (Evidence)
Entrez Gene 214384 (Evidence)
UniGene 32257
DFCI TC1585239, TC1594864, TC1595366
DoTS DT.40179725, DT.94248872, DT.97356757
NIA Mouse Gene Index U032924
Consensus CDS Project CCDS24843.1, CCDS48819.1
International Mouse Phenotyping Consortium Status Myocd
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000005903 VEGA Gene Model | MGI Sequence Detail 93381 C57BL/6J ±  kb
transcript OTTMUST00000013135 VEGA | MGI Sequence Detail 4935 Not Applicable 
polypeptide OTTMUSP00000006096 VEGA | MGI Sequence Detail 935 Not Applicable 

For the selected sequences
All sequences(54) RefSeq(12) UniProt(4)
Polymorphisms
SNPs within 2kb(865 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR004018 RPEL repeat
InterPro IPR003034 SAP domain
Protein Ontology PR:000010874 myocardin
References
(Earliest) J:70265 Wang D, et al., Activation of cardiac gene expression by myocardin, a transcriptional cofactor for serum response factor. Cell. 2001 Jun 29;105(7):851-62
(Latest) J:221298 Wang Y, et al., Deletion of yes-associated protein (YAP) specifically in cardiac and vascular smooth muscle cells reveals a crucial role for YAP in mouse cardiovascular development. Circ Res. 2014 Mar 14;114(6):957-65
All references(92)
Disease annotation references (1)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/18/2015
MGI 6.0
The Jackson Laboratory