Myocd
Gene Detail

Symbol Name ID

Myocd myocardin MGI:2137495

Synonyms

Srfcp

Feature Type

protein coding gene

Genetic Map

Chromosome 11

40.42 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)

Sequence Map

Chr11:65176561-65269941 bp, - strand From VEGA annotation of GRCm38   93381 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:17043  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Myocd

Human homologs

Human Homolog		MYOCD, myocardin
NCBI Gene ID		93649
neXtProt AC		NX_Q8IZQ8
Human Synonyms		MYCD
Human Chr (Location)		17p11.2; chr17:12569207-12670651 (+)  GRCh37.p10

Alleles and phenotypes

All alleles(7) : Targeted(7)
 

Mice homozygous for a null mutation exhibit embryonic lethality and fail to form vascular smooth muscle.

 
Human Diseases Modeled Using Mouse Myocd (1)    Alleles Annotated to Human Diseases(1)   

Gene Ontology (GO) classifications

All GO classifications: (74 annotations)

Process	cardiac muscle cell differentiation, cardiac ventricle development, ...
Component	nucleus, SRF-myogenin-E12 complex
Function	core promoter sequence-specific DNA binding, histone acetyltransferase binding, ...

This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase

Expression

Literature Summary: (31 records)
Data Summary: Results (41)    Tissues (14)   
Theiler Stages: 12, 15, 17, 26

Assay Type	Results
RNA in situ	12
RT-PCR	29

cDNA source data(15)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(21) Genomic(1) cDNA(15) Primer pair(4) Other(1)
Microarray probesets(4)

Other database links

VEGA Gene Model	OTTMUSG00000005903 (Evidence)
Ensembl Gene Model	ENSMUSG00000020542 (Evidence)
Entrez Gene	214384 (Evidence)
UniGene	32257
DFCI	TC1585239, TC1594864, TC1595366
DoTS	DT.40179725, DT.94248872, DT.97356757
NIA Mouse Gene Index	U032924
Consensus CDS Project	CCDS24843.1, CCDS48819.1
International Mouse Knockout Project Status	Myocd

Sequences

Length	Strain/Species
genomic	OTTMUSG00000005903	VEGA Gene Model | MGI Sequence Detail	93381	C57BL/6J
transcript	OTTMUST00000013135	VEGA | MGI Sequence Detail	4935	Not Applicable
polypeptide	OTTMUSP00000006096	VEGA | MGI Sequence Detail	935	Not Applicable

All sequences(46) RefSeq(4) UniProt(4)

Polymorphisms

SNPs(572 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR003034	DNA-binding SAP
InterPro	IPR004018	RPEL repeat
Protein Ontology	PR:000010874	myocardin

References

(Earliest) J:70265 Wang D, et al., Activation of cardiac gene expression by myocardin, a transcriptional cofactor for serum response factor. Cell. 2001 Jun 29;105(7):851-62
(Latest) J:192465 Huang J, et al., Myocardin regulates BMP10 expression and is required for heart development. J Clin Invest. 2012 Oct 1;122(10):3678-91
All references(78)