Rtn4r
Gene Detail

Symbol Name ID

Rtn4r reticulon 4 receptor MGI:2136886

Synonyms

NgR, NgR1, Nogo-66 receptor

Feature Type

protein coding gene

Genetic Map

Chromosome 16

11.23 cM, cytoband B1
Detailed Genetic Map ± 1 cM


Mapping data(1)

Sequence Map

Chr16:18127642-18152408 bp, + strand From VEGA annotation of GRCm38   24767 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:11299  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 2 zebrafish

Gene Tree: Rtn4r

Human homologs

Human Homolog		RTN4R, reticulon 4 receptor
NCBI Gene ID		65078
neXtProt AC		NX_Q9BZR6
Human Synonyms		NGR, NOGOR
Human Chr (Location)		22q11.21; chr22:20228938-20255816 (-)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human RTN4R

Alleles and phenotypes

All alleles(11) : Targeted(10) Chemically induced(1)
 

Homozygous null mice display decreased exploration in new environment, impaired coordination, and improved recovery and rubrospinal axon regeneration following spinal cord injury.

 

Gene Ontology (GO) classifications

All GO classifications: (8 annotations)

Process	axonogenesis
Component	anchored to membrane, cell surface, ...
Function	protein binding

External Resources: FuncBase

Expression

Literature Summary: (11 records)
Data Summary: Results (138)    Tissues (91)    Images (4)
Theiler Stages: 16, 17, 20, 21, 22, 23, 26, 28

Assay Type	Results
RNA in situ	100
RT-PCR	38

cDNA source data(7)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(9) cDNA(7) Primer pair(2)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000036604 (Evidence)
Ensembl Gene Model	ENSMUSG00000043811 (Evidence)
Entrez Gene	65079 (Evidence)
UniGene	40149
DFCI	TC1587165
DoTS	DT.60104158
NIA Mouse Gene Index	U016889
Consensus CDS Project	CCDS37279.1
International Mouse Knockout Project Status	Rtn4r

Sequences

Length	Strain/Species
genomic	OTTMUSG00000036604	VEGA Gene Model | MGI Sequence Detail	24767	C57BL/6J
transcript	OTTMUST00000093843	VEGA | MGI Sequence Detail	1938	Not Applicable
polypeptide	OTTMUSP00000052148	VEGA | MGI Sequence Detail	473	Not Applicable

All sequences(17) RefSeq(2) UniProt(1)

Polymorphisms

SNPs(61 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR000483	Cysteine-rich flanking region, C-terminal
InterPro	IPR001611	Leucine-rich repeat
InterPro	IPR000372	Leucine-rich repeat-containing N-terminal
InterPro	IPR003591	Leucine-rich repeat, typical subtype
Protein Ontology	PR:000014350	reticulon-4 receptor

References

(Earliest) J:68902 Fournier AE, et al., Identification of a receptor mediating Nogo-66 inhibition of axonal regeneration. Nature. 2001 Jan 18;409(6818):341-6
(Latest) J:193192 Rolando C, et al., Distinct roles of Nogo-a and Nogo receptor 1 in the homeostatic regulation of adult neural stem cell function and neuroblast migration. J Neurosci. 2012 Dec 5;32(49):17788-99
All references(69)