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Rtn4r Gene Detail
Summary
  • Symbol
    Rtn4r
  • Name
    reticulon 4 receptor
  • Synonyms
    NgR, NgR1, Nogo-66 receptor
  • Feature Type
    protein coding gene
  • IDs
    MGI:2136886
    NCBI Gene: 65079
  • Gene Overview
    MyGene.info: RTN4R
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr16:18127642-18152408 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      24767 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 16, 11.23 cM, cytoband B1
  • Mapping Data
    1 experiment
Homology
more
  • Human Ortholog
    RTN4R, reticulon 4 receptor
  • Vertebrate Orthologs
    11
  • Human Ortholog
    RTN4R, reticulon 4 receptor
    Orthology source: HomoloGene, HGNC
  • Synonyms
    NGR, NOGOR
  • Links
    NCBI Gene ID: 65078
    neXtProt AC: NX_Q9BZR6
    UniProt: Q9BZR6

  • Chr Location
    22q11.21; chr22:20241415-20268293 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 11299
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;2 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: RTN4R
  • Gene Tree
Human Diseases
more
  • Diseases
    1 with human RTN4R associations

Human Disease Mouse Models
      
IDs
View 2 "NOT" models
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    7 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    13 phenotypes from 8 alleles in 9 genetic backgrounds
    4 phenotypes from multigenic genotypes
    110 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous null mice display decreased exploration in new environment, impaired coordination, and improved recovery and rubrospinal axon regeneration following spinal cord injury.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000036604 VEGA Gene Model | MGI Sequence Detail 24767 C57BL/6J ±  kb
    transcript OTTMUST00000093843 VEGA | MGI Sequence Detail 1938 Not Applicable  
    polypeptide OTTMUSP00000052148 VEGA | MGI Sequence Detail 473 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      68 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 10
      cDNA 8
      Primer pair 2

      Microarray probesets 3
    References
    more
    • Summaries
      All 158
      Developmental Gene Expression 14
      Diseases 7
      Gene Ontology 11
      Phenotypes 110
    • Earliest
      J:57757 Lindsay EA, et al., Congenital heart disease in mice deficient for the DiGeorge syndrome region [see comments]. Nature. 1999 Sep 23;401(6751):379-83
    • Latest
      J:265457 Zamponi E, et al., Nrf2 stabilization prevents critical oxidative damage in Down syndrome cells. Aging Cell. 2018 Oct;17(5):e12812

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    10/09/2018
    MGI 6.12
    The Jackson Laboratory