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Rtn4r
Gene Detail
 Symbol
Name
ID
Rtn4r
reticulon 4 receptor
MGI:2136886
Synonyms NgR, NgR1, Nogo-66 receptor
Feature Type protein coding gene
Genetic Map
Chromosome 16
11.23 cM, cytoband B1
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr16:18127642-18152408 bp, + strand
From VEGA annotation of GRCm38

  24767 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:11299  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 2 zebrafish

Gene Tree: Rtn4r

Human
homologs
Human Homolog RTN4R, reticulon 4 receptor
NCBI Gene ID 65078
neXtProt AC  NX_Q9BZR6
Human Synonyms  NGR, NOGOR
Human Chr (Location)  22q11.21; chr22:20241415-20268293 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human RTN4R
Alleles
and
phenotypes
All alleles(13) : Targeted(12) Chemically induced(1)
 
Homozygous null mice display decreased exploration in new environment, impaired coordination, and improved recovery and rubrospinal axon regeneration following spinal cord injury.
 
Gene Ontology
(GO)
classifications
All GO classifications: (8 annotations)
Process axonogenesis
Component anchored component of membrane, cell surface, ...
Function protein binding
External Resources: FuncBase
Expression
Literature Summary: (11 records)
Data Summary: Results (138)    Tissues (91)    Images (4)
Theiler Stages: 16, 17, 20, 21, 22, 23, 26, 28
Assay TypeResults
RNA in situ 100
RT-PCR 38
cDNA source data(7)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(9) cDNA(7) Primer pair(2)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000036604 (Evidence)
Ensembl Gene ModelENSMUSG00000043811 (Evidence)
Entrez Gene65079 (Evidence)
UniGene40149
DFCITC1587165
DoTSDT.60104158
NIA Mouse Gene IndexU016889
Consensus CDS ProjectCCDS37279.1
International Mouse Knockout Project StatusRtn4r
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000036604 VEGA Gene Model | MGI Sequence Detail 24767 C57BL/6J ±  kb
transcript OTTMUST00000093843 VEGA | MGI Sequence Detail 1938 Not Applicable 
polypeptide OTTMUSP00000052148 VEGA | MGI Sequence Detail 473 Not Applicable 

For the selected sequences
All sequences(17) RefSeq(2) UniProt(1)
Polymorphisms SNPs within 2kb(68 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000483 Cysteine-rich flanking region, C-terminal
InterPro IPR001611 Leucine-rich repeat
InterPro IPR000372 Leucine-rich repeat-containing N-terminal
InterPro IPR003591 Leucine-rich repeat, typical subtype
Protein Ontology PR:000014350 reticulon-4 receptor
References (Earliest) J:68902 Fournier AE, et al., Identification of a receptor mediating Nogo-66 inhibition of axonal regeneration. Nature. 2001 Jan 18;409(6818):341-6
(Latest) J:197940 Akbik FV, et al., Anatomical plasticity of adult brain is titrated by Nogo Receptor 1. Neuron. 2013 Mar 6;77(5):859-66
All references(71)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
04/08/2014
MGI 5.17
The Jackson Laboratory