About   Help   FAQ
Rtn4r Gene Detail
Summary
  • Symbol
    Rtn4r
  • Name
    reticulon 4 receptor
  • Synonyms
    NgR, NgR1, Nogo-66 receptor
  • Feature Type
    protein coding gene
  • IDs
    MGI:2136886
    NCBI Gene: 65079
  • Gene Overview
    MyGene.info: RTN4R
Location & Maps
more
  • Sequence Map
    Chr16:18127642-18152408 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      24767 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 16, 11.23 cM, cytoband B1
  • Mapping Data
    1 experiment
Homology
more
  • Human Ortholog
    RTN4R, reticulon 4 receptor
  • Vertebrate Orthologs
    11
  • Human Ortholog
    RTN4R, reticulon 4 receptor
    Orthology source: HomoloGene, HGNC
  • Synonyms
    NGR, NOGOR
  • Links
    NCBI Gene ID: 65078
    neXtProt AC: NX_Q9BZR6

  • Chr Location
    22q11.21; chr22:20241415-20268293 (-)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 11299
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;2 zebrafish;1 frog, western clawed
  • HCOP
    human homology predictions: RTN4R
  • Gene Tree
Human Diseases
more
  • Diseases
    1 with Rtn4r mouse models; 1 with human RTN4R associations

Human Disease Mouse Models
       Schizophrenia; SCZD   OMIM: 181500 View 2 "NOT" models
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    14 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    12 phenotypes from 7 alleles in 8 genetic backgrounds
    4 phenotypes from multigenic genotypes
    79 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    23
  • Chemically induced (ENU)
    1
  • Targeted
    22
  • Genomic Mutations
    9 involving Rtn4r
  • Incidental Mutations
    APF , CvDC
Homozygous null mice display decreased exploration in new environment, impaired coordination, and improved recovery and rubrospinal axon regeneration following spinal cord injury.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000036604 VEGA Gene Model | MGI Sequence Detail 24767 C57BL/6J ±  kb
transcript OTTMUST00000093843 VEGA | MGI Sequence Detail 1938 Not Applicable  
polypeptide OTTMUSP00000052148 VEGA | MGI Sequence Detail 473 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    68 from dbSNP Build 142
Protein
Information
less
  • UniProt
    1 Sequence
  • Protein Ontology
    PR:000014350 reticulon-4 receptor
  • InterPro Domains
    IPR001611 Leucine-rich repeat
    IPR032675 Leucine-rich repeat domain, L domain-like
    IPR003591 Leucine-rich repeat, typical subtype
Molecular
Reagents
less
  • All nucleic 9
    cDNA 7
    Primer pair 2

    Microarray probesets 3
References
more
  • Summaries
    All 81
    Developmental Gene Expression 13
    Diseases 14
    Gene Ontology 7
    Phenotypes 79
  • Earliest
    J:68902 Fournier AE, et al., Identification of a receptor mediating Nogo-66 inhibition of axonal regeneration. Nature. 2001 Jan 18;409(6818):341-6
  • Latest
    J:231310 Karlsson TE, et al., NgR1: A Tunable Sensor Regulating Memory Formation, Synaptic, and Dendritic Plasticity. Cereb Cortex. 2016 Apr;26(4):1804-17

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
09/13/2016
MGI 6.05
The Jackson Laboratory