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Fam20c
Gene Detail
Symbol

Name
ID
Fam20c
family with sequence similarity 20, member C
MGI:2136853
Synonyms
DMP4, MGC:7673
Feature Type
protein coding gene
Genetic Map
Chromosome 5
77.19 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr5:138754514-138810077 bp, + strand
From VEGA annotation of GRCm38

  55564 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:56879  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 2 zebrafish

HCOP human homology predictions: FAM20C
Gene Tree: Fam20c

Human
homologs
FAM20C, family with sequence similarity 20, member C
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 56975
neXtProt AC: NX_Q8IXL6

Human Synonyms: DMP4, DMP-4, GEF-CK, RNS

Human Chr (Location): 7p22.3; chr7:192777-260774 (+)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human FAM20C

Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Mice with global conditional deletion of this gene display infertility, dwarfism, delayed bone ossification, reduced bone mineralization, fragile skeletons, hypophosphatemic rickets, and impaired osteoblast differentiation.
 
Phenotype Images(6)
Interactions
Fam20c interacts with 202 markers (Mir17, Mir20b, Mir22, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (29 annotations)
Process biomineral tissue development, dentinogenesis, ...
Component extracellular exosome, extracellular region, ...
Function ATP binding, calcium ion binding, ...
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (5)    Tissues (5)    Images (3)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 5
cDNA source data(109)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase fam20c    NEW 
Molecular
reagents
All nucleic(109) cDNA(109)
Microarray probesets(5)
Other database
links
VEGA Gene Model OTTMUSG00000030351 (Evidence)
Ensembl Gene Model ENSMUSG00000025854 (Evidence)
Entrez Gene 80752 (Evidence)
UniGene 320355
DFCI TC1575406
DoTS DT.110689826, DT.529700
NIA Mouse Gene Index U006351
EC 2.7.11.1
Consensus CDS Project CCDS51681.1
International Mouse Phenotyping Consortium Status Fam20c
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000030351 VEGA Gene Model | MGI Sequence Detail 55564 C57BL/6J ±  kb
transcript OTTMUST00000075201 VEGA | MGI Sequence Detail 3582 Not Applicable 
polypeptide OTTMUSP00000039361 VEGA | MGI Sequence Detail 579 Not Applicable 

For the selected sequences
All sequences(48) RefSeq(4) UniProt(2)
Polymorphisms
SNPs within 2kb(425 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR024869 FAM20
InterPro IPR009581 FAM20, C-terminal
Protein Ontology PR:000031718 extracellular serine/threonine protein kinase Fam20C
References
(Earliest) J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
(Latest) J:215016 Miyagawa K, et al., Dysregulated gene expression in the primary osteoblasts and osteocytes isolated from hypophosphatemic Hyp mice. PLoS One. 2014;9(4):e93840
All references(37)
Disease annotation references (1)
Other
accession IDs
MGI:2141281

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory