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Fam20c
Gene Detail
 Symbol
Name
ID
Fam20c
family with sequence similarity 20, member C
MGI:2136853
Synonyms DMP4, MGC:7673
Feature Type protein coding gene
Genetic Map
Chromosome 5
77.19 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr5:138754514-138810077 bp, + strand
From VEGA annotation of GRCm38

  55564 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:56879  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 2 zebrafish

Gene Tree: Fam20c

Human
homologs
Human Homolog FAM20C, family with sequence similarity 20, member C
NCBI Gene ID 56975
neXtProt AC  NX_Q8IXL6
Human Synonyms  DMP4, DMP-4, GEF-CK, RNS
Human Chr (Location)  7p22.3; chr7:192969-260774 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human FAM20C
Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Mice with global conditional deletion of this gene display infertility, dwarfism, delayed bone ossification, reduced bone mineralization, fragile skeletons, hypophosphatemic rickets, and impaired osteoblast differentiation.
 
Phenotype Images(6)
Interactions
Fam20c interacts with 203 markers (Mir17, Mir20b, Mir22, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (23 annotations)
Process biomineral tissue development, dentinogenesis, ...
Component extracellular region, extracellular space, ...
Function calcium ion binding, kinase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (5)    Tissues (5)    Images (3)
Theiler Stages: 12, 23, 28
Assay TypeResults
RNA in situ 5
cDNA source data(109)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(109) cDNA(109)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000030351 (Evidence)
Ensembl Gene ModelENSMUSG00000025854 (Evidence)
Entrez Gene80752 (Evidence)
UniGene320355
DFCITC1575406
DoTSDT.110689826, DT.529700
NIA Mouse Gene IndexU006351
EC2.7.11.1
Consensus CDS ProjectCCDS51681.1
International Mouse Knockout Project StatusFam20c
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000030351 VEGA Gene Model | MGI Sequence Detail 55564 C57BL/6J ±  kb
transcript OTTMUST00000075201 VEGA | MGI Sequence Detail 3582 Not Applicable 
polypeptide OTTMUSP00000039361 VEGA | MGI Sequence Detail 579 Not Applicable 

For the selected sequences
All sequences(42) RefSeq(4) UniProt(2)
Polymorphisms SNPs within 2kb(425 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR009581 Domain of unknown function DUF1193
InterPro IPR024869 FAM20
Protein Ontology PR:000031718 extracellular serine/threonine protein kinase Fam20C
References (Earliest) J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
(Latest) J:192135 Wang X, et al., FAM20C plays an essential role in the formation of murine teeth. J Biol Chem. 2012 Oct 19;287(43):35934-42
All references(37)
Other
accession IDs
MGI:2141281

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/23/2014
MGI 5.19
The Jackson Laboratory