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Fam20c Gene Detail
Summary
  • Symbol
    Fam20c
  • Name
    family with sequence similarity 20, member C
  • Synonyms
    DMP4, MGC:7673
  • Feature Type
    protein coding gene
  • IDs
    MGI:2136853
    NCBI Gene: 80752
  • Gene Overview
    MyGene.info: FAM20C
Location & Maps
more
  • Sequence Map
    Chr5:138754514-138810077 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      55564 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 5, 77.19 cM
  • Mapping Data
    1 experiment
Homology
more
  • Human Ortholog
    FAM20C, FAM20C, golgi associated secretory pathway kinase
  • Vertebrate Orthologs
    11
  • Human Ortholog
    FAM20C, FAM20C, golgi associated secretory pathway kinase
    Orthology source: HomoloGene, HGNC
  • Synonyms
    DMP4, DMP-4, G-CK, GEF-CK, RNS
  • Links
    NCBI Gene ID: 56975
    neXtProt AC: NX_Q8IXL6

  • Chr Location
    7p22.3; chr7:192777-260774 (+)  GRCh38.p2

Human Diseases
more
  • Diseases
    2 with Fam20c mouse models; 1 with human FAM20C associations

Human Disease Mouse Models
       Raine Syndrome; RNS   OMIM: 259775 View 1 "NOT" model
       Periodontitis, Chronic   OMIM: 260950 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    78 phenotypes from 3 alleles in 4 genetic backgrounds
    6 images
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice with global conditional deletion of this gene display infertility, dwarfism, delayed bone ossification, reduced bone mineralization, fragile skeletons, hypophosphatemic rickets, and impaired osteoblast differentiation.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000030351 VEGA Gene Model | MGI Sequence Detail 55564 C57BL/6J ±  kb
transcript OTTMUST00000075201 VEGA | MGI Sequence Detail 3582 Not Applicable  
polypeptide OTTMUSP00000039361 VEGA | MGI Sequence Detail 579 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    429 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 109
    cDNA 109

    Microarray probesets 5
Other
Accession IDs
less
MGI:2141281
References
more
  • Summaries
    All 37
    Developmental Gene Expression 3
    Diseases 2
    Gene Ontology 6
    Phenotypes 10
  • Earliest
    J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
  • Latest
    J:227247 Brommage R, et al., High-throughput screening of mouse gene knockouts identifies established and novel skeletal phenotypes. Bone Res. 2014;2:14034

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/27/2016
MGI 6.05
The Jackson Laboratory