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Gpr45 Gene Detail
Summary
  • Symbol
    Gpr45
  • Name
    G protein-coupled receptor 45
  • Synonyms
    9230112G11Rik, PSP24alpha
  • Feature Type
    protein coding gene
  • IDs
    MGI:2135882
    NCBI Gene: 93690
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:42992032-43074611 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 21.88 cM, cytoband C1
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    205 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2135882
 protein coding gene Chr1:42992032-43074616 (+)
129S1/SvImJ MGP_129S1SvImJ_G0015976
 protein coding gene Chr1:41916122-41997615 (+)
A/J MGP_AJ_G0015960
 protein coding gene Chr1:40665235-40743065 (+)
AKR/J MGP_AKRJ_G0015915
 protein coding gene Chr1:41189182-41273815 (+)
BALB/cJ MGP_BALBcJ_G0015914
 protein coding gene Chr1:40330915-40416218 (+)
C3H/HeJ MGP_C3HHeJ_G0015747
 protein coding gene Chr1:41567351-41654541 (+)
C57BL/6NJ MGP_C57BL6NJ_G0016367
 protein coding gene Chr1:43646391-43732706 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0014089
 protein coding gene Chr1:37490037-37575494 (+)
CAST/EiJ MGP_CASTEiJ_G0015328
 protein coding gene Chr1:41550614-41640604 (+)
CBA/J MGP_CBAJ_G0015719
 protein coding gene Chr1:44933781-45011608 (+)
DBA/2J MGP_DBA2J_G0015820
 protein coding gene Chr1:39934816-40018111 (+)
FVB/NJ MGP_FVBNJ_G0015822
 protein coding gene Chr1:39464420-39547312 (+)
LP/J MGP_LPJ_G0015890
 protein coding gene Chr1:42259514-42347895 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0015842
 protein coding gene Chr1:46908501-47006187 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0016414
 protein coding gene Chr1:41397917-41485884 (+)
PWK/PhJ MGP_PWKPhJ_G0015111
 protein coding gene Chr1:39814903-39900500 (+)
SPRET/EiJ MGP_SPRETEiJ_G0014893
 protein coding gene Chr1:41396236-41476486 (+)
WSB/EiJ MGP_WSBEiJ_G0015390
 protein coding gene Chr1:41438730-41525129 (+)



Homology
more
  • Human Ortholog
    GPR45, G protein-coupled receptor 45
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    GPR45, G protein-coupled receptor 45
  • Synonyms
    PSP24, PSP24A, PSP24(ALPHA)
  • Links
    NCBI Gene ID: 11250
    neXtProt AC: NX_Q9Y5Y3
    UniProt: Q9Y5Y3

  • Chr Location
    2q12.1; chr2:105241743-105243467 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    3
  • GO References
    2
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    755
  • Tissues
    49
  • cDNA Data
    10
  • Literature Summary
    1
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 93690 NCBI Gene Model | MGI Sequence Detail 82580 C57BL/6J ±  kb
transcript NM_053107 RefSeq | MGI Sequence Detail 3860 C57BL/6  
polypeptide Q9EQQ4 UniProt | EBI | MGI Sequence Detail 373 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 10
    cDNA 10

    Microarray probesets 4
Other
Accession IDs
less
MGI:1925334, MGI:2138544
References
more
  • Summaries
    All 32
    Developmental Gene Expression 1
    Gene Ontology 2
    Phenotypes 5
  • Earliest
    J:68328 Kawasawa Y, et al., Brain-specific expression of novel G-protein-coupled receptors, with homologies to Xenopus PSP24 and human GPR45. Biochem Biophys Res Commun. 2000 Oct 5;276(3):952-6
  • Latest
    J:237251 Cui J, et al., Disruption of Gpr45 causes reduced hypothalamic POMC expression and obesity. J Clin Invest. 2016 Sep 01;126(9):3192-206
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory