Gpr45 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Gpr45
G protein-coupled receptor 45
MGI:2135882

36 phenotypes from 6 alleles in 8 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Gpr45^em1Zz/Gpr45^em1Zz C57BL/6J-Gpr45^em1Zz	abnormal adipose tissue amount	J:367505
	enlarged liver	J:367505
	hepatic steatosis	J:367505
	normal homeostasis/metabolism phenotype	J:367505
	impaired glucose tolerance	J:367505
	increased brown adipose tissue amount	J:367505
	increased circulating cholesterol level	J:367505
	increased fasting circulating glucose level	J:367505
	increased fat cell size	J:367505
	increased liver triglyceride level	J:367505
	increased liver weight	J:367505
	increased respiratory quotient	J:367505
	increased white adipose tissue amount	J:367505
	insulin resistance	J:367505
	obese	J:367505
	pale liver	J:367505
	polyphagia	J:367505
Gpr45^em2Zz/Gpr45^em2Zz C57BL/6J-Gpr45^em2Zz	increased body weight	J:367505
Gpr45^em2Zz/Gpr45^em2Zz Mc4r^{tm3.1(cre)Lowl}/Mc4r⁺ involves: 129S6/SvEvTac * C57BL/6	increased body weight	J:367505
	increased susceptibility to diet-induced obesity	J:367505
Gpr45^em2Zz/Gpr45^em2Zz Tg(Pomc-cre)1Lowl/0 B6.Cg-Gpr45^em2Zz Tg(Pomc-cre)1Lowl	normal growth/size/body region phenotype	J:367505
Gpr45^em2Zz/Gpr45^em2Zz Tg(Sim1-cre)1Lowl/0 involves: C57BL/6J * FVB	increased body weight	J:367505
	increased susceptibility to diet-induced obesity	J:367505
Gpr45^m1Btlr/Gpr45^m1Btlr C57BL/6J-Gpr45^m1Btlr	increased body weight	J:367505
Gpr45^m2Btlr/Gpr45^m2Btlr C57BL/6J-Gpr45^m2Btlr	increased body weight	J:367505
Gpr45^{Tn(pb-Act-RFP)1.1Zhu}/Gpr45⁺ involves: FVB/NJ	decreased lean body mass	J:237251
Gpr45^{Tn(pb-Act-RFP)1.1Zhu}/Gpr45^{Tn(pb-Act-RFP)1.1Zhu} involves: FVB/NJ	abnormal glucose homeostasis	J:237251
	abnormal nervous system electrophysiology	J:237251
	normal behavior/neurological phenotype	J:237251
	decreased body temperature	J:237251
	decreased energy expenditure	J:237251
	decreased lean body mass	J:237251
	decreased locomotor activity	J:237251
	hepatic steatosis	J:237251
	hyperglycemia	J:237251
	impaired adaptive thermogenesis	J:237251
	impaired glucose tolerance	J:237251
	increased body weight	J:237251
	increased circulating insulin level	J:237251
	increased circulating leptin level	J:237251
	increased gonadal fat pad weight	J:237251
	increased interscapular fat pad weight	J:237251
	increased liver weight	J:237251
	increased retroperitoneal fat pad weight	J:237251
	increased sleep duration	J:237251
	increased total body fat amount	J:237251
	insulin resistance	J:237251
	obese	J:237251
Gpr45^{Tn(pb-Act-RFP)1.2Zhu}/Gpr45^{Tn(pb-Act-RFP)1.2Zhu} involves: FVB/NJ	impaired glucose tolerance	J:237251
	increased body weight	J:237251
	increased total body fat amount	J:237251

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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