Gpr45^{Tn(pb-Act-RFP)1.1Zhu}
Transposon induced Allele Detail

Summary

• Symbol: Gpr45^{Tn(pb-Act-RFP)1.1Zhu}
• Name: G protein-coupled receptor 45; transposon insertion 1.1, Yuan Zhuang
• MGI ID: MGI:8213372
• Synonyms: Gpr45^PB1
• Gene: Gpr45 Location: Chr1:42992032-43074611 bp, + strand Genetic Position: Chr1, 21.88 cM, cytoband C1
• Alliance: Gpr45^{Tn(pb-Act-RFP)1.1Zhu} page

Mutation origin

• Strain of Origin: FVB/NJ

Mutation description

• Allele Type: Transposon induced (Hypomorph)
• Mutation: Insertion
• Mutation details: The transposon construct inserted at 34,038 bp upstream of the single coding exon (exon 2). This insertion results in a nearly complete loss (97.5%) of mRNA expression in homozygous mice. (J:237251)

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gpr45 Mutation: 25 strains or lines available

References

• Original: J:237251 Cui J, et al., Disruption of Gpr45 causes reduced hypothalamic POMC expression and obesity. J Clin Invest. 2016 Sep 01;126(9):3192-206
• All: 1 reference(s)