Park7
Gene Detail

Symbol Name ID

Park7 Parkinson disease (autosomal recessive, early onset) 7 MGI:2135637

Synonyms

DJ-1

Feature Type

protein coding gene

Genetic Map

Chromosome 4

81.52 cM, cytoband E1
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr4:150897133-150914437 bp, - strand From VEGA annotation of GRCm38   17305 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:38295  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Park7

Human homologs

Human Homolog		PARK7, parkinson protein 7
NCBI Gene ID		11315
neXtProt AC		NX_Q99497
Human Synonyms		DJ1, DJ-1
Human Chr (Location)		1p36.23; chr1:8021714-8045342 (+)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human PARK7

Alleles and phenotypes

All alleles(88) : Targeted(6) Gene trapped(82)
 

Homozygous null mice exhibit reduced evoked dopamine overflow in the striatum, resulting primarily from increased dopamine uptake. Mice show hyopactivity, absent long-term depression in medium spiny neurons and decreased sensitivity of nigral neurons to dopamine.

 
Human Diseases Modeled Using Mouse Park7 (1)    Alleles Annotated to Human Diseases(3)    Phenotype Images(1)

Gene Ontology (GO) classifications

All GO classifications: (46 annotations)

Process	adult locomotory behavior, autophagy, ...
Component	axon, cytoplasm, ...
Function	hydrolase activity, mRNA binding, ...

This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase

Expression

Literature Summary: (1 records)
Data Summary: Results (29)    Tissues (29)    Images (8)
Theiler Stages: 19, 23, 28

Assay Type	Results
RNA in situ	29

cDNA source data(198)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(198) cDNA(198)
Microarray probesets(4)

Other database links

VEGA Gene Model	OTTMUSG00000010158 (Evidence)
Ensembl Gene Model	ENSMUSG00000028964 (Evidence)
Entrez Gene	57320 (Evidence)
UniGene	277349
DFCI	TC1572248, TC1690229
DoTS	DT.55101132, DT.94280645, DT.99864019
NIA Mouse Gene Index	U025821
EC	3.4.-.-
Consensus CDS Project	CCDS18975.1
International Mouse Knockout Project Status	Park7

Sequences

Length	Strain/Species
genomic	OTTMUSG00000010158	VEGA Gene Model | MGI Sequence Detail	17305	C57BL/6J
transcript	OTTMUST00000023792	VEGA | MGI Sequence Detail	882	Not Applicable
polypeptide	OTTMUSP00000010895	VEGA | MGI Sequence Detail	189	Not Applicable

All sequences(64) RefSeq(2) UniProt(6)

Polymorphisms

SNPs(81 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR006287	DJ-1
InterPro	IPR002818	ThiJ/PfpI
Protein Ontology	PR:000012286	protein DJ-1

References

(Earliest) J:52842 Nagakubo D, et al., DJ-1, a novel oncogene which transforms mouse NIH3T3 cells in cooperation with ras. Biochem Biophys Res Commun. 1997 Feb 13;231(2):509-13
(Latest) J:194438 Sheng C, et al., DJ-1 deficiency perturbs microtubule dynamics and impairs striatal neurite outgrowth. Neurobiol Aging. 2013 Feb;34(2):489-98
All references(81)