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Park7
Gene Detail
Symbol

Name
ID
Park7
Parkinson disease (autosomal recessive, early onset) 7
MGI:2135637
Synonyms
DJ-1
Feature Type
protein coding gene
Genetic Map
Chromosome 4
81.52 cM, cytoband E1
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr4:150897133-150914437 bp, - strand
From VEGA annotation of GRCm38

  17305 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:38295  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Park7

Human
homologs
Human Homolog PARK7, parkinson protein 7
NCBI Gene ID 11315
neXtProt AC  NX_Q99497
Human Synonyms  DJ1, DJ-1, HEL-S-67p
Human Chr (Location)  1p36.23; chr1:7961654-7985282 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human PARK7
Mutations,
alleles, and
phenotypes
All mutations/alleles(90) : Gene trapped(82) Targeted(8)
Genomic Mutations involving Park7 (2)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null mice exhibit reduced evoked dopamine overflow in the striatum, resulting primarily from increased dopamine uptake. Mice show hyopactivity, absent long-term depression in medium spiny neurons and decreased sensitivity of nigral neurons to dopamine.
 
Human Diseases Modeled Using Mouse Park7 (1)    Alleles Annotated to Human Diseases(3)    Phenotype Images(1)
Interactions
Park7 interacts with 25 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (120 annotations)
Process adult locomotory behavior, autophagy, ...
Component axon, chromatin, ...
Function androgen receptor binding, cupric ion binding, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (1 records)
Data Summary: Results (29)    Tissues (29)    Images (8)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 29
cDNA source data(197)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(197) cDNA(197)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000010158 (Evidence)
Ensembl Gene ModelENSMUSG00000028964 (Evidence)
Entrez Gene57320 (Evidence)
UniGene277349
DFCITC1572248, TC1690229
DoTSDT.55101132, DT.94280645, DT.99864019
NIA Mouse Gene IndexU025821
EC3.4.-.-
Consensus CDS ProjectCCDS18975.1
International Mouse Knockout Project StatusPark7
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000010158 VEGA Gene Model | MGI Sequence Detail 17305 C57BL/6J ±  kb
transcript OTTMUST00000023609 VEGA | MGI Sequence Detail 908 Not Applicable 
polypeptide OTTMUSP00000010787 VEGA | MGI Sequence Detail 189 Not Applicable 

For the selected sequences
All sequences(66) RefSeq(4) UniProt(6)
Polymorphisms
SNPs within 2kb(197 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR006287 DJ-1
InterPro IPR002818 ThiJ/PfpI
Protein Ontology PR:000012286 protein DJ-1
References
(Earliest) J:52842 Nagakubo D, et al., DJ-1, a novel oncogene which transforms mouse NIH3T3 cells in cooperation with ras. Biochem Biophys Res Commun. 1997 Feb 13;231(2):509-13
(Latest) J:211328 Ma J, et al., DJ-1 interacts with RACK1 and protects neurons from oxidative-stress-induced apoptosis. Biochem J. 2014 Jun 20;
All references(98)
Disease annotation references (4)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
10/08/2014
MGI 5.20
The Jackson Laboratory