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Park7 Gene Detail
Summary
  • Symbol
    Park7
  • Name
    Parkinson disease (autosomal recessive, early onset) 7
  • Synonyms
    DJ-1
  • Feature Type
    protein coding gene
  • IDs
    MGI:2135637
    NCBI Gene: 57320
  • Gene Overview
    MyGene.info: PARK7
Location & Maps
more
  • Sequence Map
    Chr4:150897133-150914437 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      17305 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 4, 81.52 cM, cytoband E1
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    PARK7, Parkinsonism associated deglycase
  • Vertebrate Orthologs
    8
  • Human Ortholog
    PARK7, Parkinsonism associated deglycase
    Orthology source: HomoloGene, HGNC
  • Synonyms
    DJ1, DJ-1, HEL-S-67p
  • Links
    NCBI Gene ID: 11315
    neXtProt AC: NX_Q99497

  • Chr Location
    1p36.23; chr1:7961654-7985283 (+)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with Park7 mouse models; 1 with human PARK7 associations

Human Disease Mouse Models
       Parkinson Disease 7, Autosomal Recessive Early-Onset; PARK7   OMIM: 606324 View 4 models
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    4 with disease annotations
  • References
    6 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    31 phenotypes from 6 alleles in 7 genetic backgrounds
    3 phenotypes from multigenic genotypes
    1 images
    64 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    91
  • Gene trapped
    82
  • Targeted
    9
  • Genomic Mutations
    3 involving Park7
  • Incidental Mutations
Homozygous null mice exhibit reduced evoked dopamine overflow in the striatum, resulting primarily from increased dopamine uptake. Mice show hyopactivity, absent long-term depression in medium spiny neurons and decreased sensitivity of nigral neurons to dopamine.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000010158 VEGA Gene Model | MGI Sequence Detail 17305 C57BL/6J ±  kb
transcript OTTMUST00000023609 VEGA | MGI Sequence Detail 908 Not Applicable  
polypeptide OTTMUSP00000010787 VEGA | MGI Sequence Detail 189 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    197 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 197
    cDNA 197

    Microarray probesets 4
References
more
  • Summaries
    All 123
    Developmental Gene Expression 1
    Diseases 6
    Gene Ontology 30
    Phenotypes 64
  • Earliest
    J:52842 Nagakubo D, et al., DJ-1, a novel oncogene which transforms mouse NIH3T3 cells in cooperation with ras. Biochem Biophys Res Commun. 1997 Feb 13;231(2):509-13
  • Latest
    J:230864 Meiser J, et al., Loss of DJ-1 impairs antioxidant response by altered glutamine and serine metabolism. Neurobiol Dis. 2016 May;89:112-25

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/29/2016
MGI 6.06
The Jackson Laboratory