Park7 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Park7
Parkinson disease (autosomal recessive, early onset) 7
MGI:2135637

33 phenotypes from 7 alleles in 8 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Park7^em1(IMPC)H/Park7^em1(IMPC)H C57BL/6NTac-Park7^em1(IMPC)H/H	abnormal head morphology	J:211773
	decreased bone mineral density	J:211773
Park7^Gt(XE726)Byg/Park7^Gt(XE726)Byg involves: 129P2/OlaHsd * C57BL/6	abnormal dopamine level	J:134826
	abnormal motor coordination/balance	J:134826
	increased susceptibility to dopaminergic neuron neurotoxicity	J:134826
Park7^tm1Cai/Park7^tm1Cai involves: 129X1/SvJ * C57BL/6	abnormal gait	J:141628
	abnormal motor learning	J:141628
	decreased grip strength	J:141628
	decreased locomotor activity	J:141628
	short stride length	J:141628
	weight loss	J:141628
Park7^tm1Dsp/Park7^tm1Dsp B6.129P2-Park7^tm1Dsp	abnormal behavioral response to xenobiotic	J:97366
	abnormal locus ceruleus morphology	J:190315
	abnormal motor capabilities/coordination/movement	J:190315
	abnormal physiological response to xenobiotic	J:97366
	abnormal striatum morphology	J:190315
	abnormal substantia nigra pars compacta morphology	J:190315
	decreased grip strength	J:190315
	loss of dopaminergic neurons	J:190315
	neuron degeneration	J:190315
Park7^tm1Shn/Park7^tm1Shn B6.Cg-Park7^tm1Shn/J	impaired coordination	J:202221
Park7^tm1Shn/Park7^tm1Shn involves: 129 * C57BL/6	abnormal action potential	J:98436
	abnormal locomotor activation	J:134518
	abnormal neurotransmitter uptake	J:98436
	abnormal stationary movement	J:134518
	absent long-term depression	J:98436
	normal behavior/neurological phenotype	J:134518
	bradykinesia	J:98436
	decreased vertical activity	J:98436
	normal nervous system phenotype	J:134518
Park7^tm1Tmd/Park7^tm1Tmd involves: 129S/SvEv * C57BL/6	abnormal cellular respiration	J:125021
	abnormal tricarboxylic acid cycle	J:125021
	normal nervous system phenotype	J:125021
Park7^tm1Xz/Park7^tm1Xz involves: 129P2/OlaHsd * C57BL/6J	decreased locomotor activity	J:99905
	decreased vertical activity	J:99905
	impaired limb coordination	J:99905
	increased dopamine level	J:99905

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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