Park7^Gt(XE726)Byg
Gene trapped Allele Detail

Summary

• Symbol: Park7^Gt(XE726)Byg
• Name: Parkinson disease (autosomal recessive, early onset) 7; gene trap XE726, BayGenomics
• MGI ID: MGI:3587946
• Synonyms: DJ-1^-, Park7^{Gt(pGT1Lxf)1Ucd}
• Gene: Park7 Location: Chr4:150981590-150994378 bp, - strand Genetic Position: Chr4, 81.52 cM, cytoband E1
• Alliance: Park7^Gt(XE726)Byg page

Mutation origin

• Mutant Cell Line: XE726
• Germline Transmission: Earliest citation of germline transmission: J:134826
• Parent Cell Line: Other (see notes) (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Gene trapped (Null/knockout, Reporter)
• Mutation: Insertion of gene trap vector Vector: pGT1Lxf Vector Type: gene trap
• Mutation details: The beta-geo gene trap cassette was inserted between exons 6 and 7. The absence of protein product was confirmed by western blot analysis on striatum extracts. This is a gene trapped allele, reporter allele and null allele. (J:134826)
• Sequence Tags: Sequence tag details (1 tag)

  Tag ID	GenBank ID	Method	Tag Location (trapped strand)*	Select
  XE726	CC183350 ; (MGI Seq Detail)	5' RACE	Chr4:150985464-150994310 bp (-)
  * GRCm39; (strand of gene trap mutagenesis)

• Genome Context: Genome Browser view of this mutation;

  63 gene trap insertions have trapped this gene; View all gene trap sequence tags in this region

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Park7 Mutation: 53 strains or lines available

Notes

All BayGenomics gene trap mutations were generated in either CGR8 or E14TG2a (129P2/OlaHsd) parental ES cell lines, with the majority in subline E14TG2a.4. The specific ES cell line in which each mutation was made is not specified.

References

• Original: J:134826 Manning-Bog AB, et al., Increased vulnerability of nigrostriatal terminals in DJ-1-deficient mice is mediated by the dopamine transporter. Neurobiol Dis. 2007 Aug;27(2):141-50
• All: 22 reference(s)