Sequence Detail

ID/Version

Q99LX0 Q3THB9 Q3U509 O88306 (UniProt | EBI)

Last sequence update: 2001-06-01
Last annotation update: 2024-03-27

Sequence description from provider

RecName: Full=Parkinson disease protein 7 homolog {ECO:0000305};AltName: Full=Maillard deglycase {ECO:0000250|UniProtKB:Q99497};AltName: Full=Parkinsonism-associated deglycase {ECO:0000250|UniProtKB:Q99497};AltName: Full=Protein DJ-1 {ECO:0000305};

Provider

SWISS-PROT

Sequence

Polypeptide 189 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Park7	Parkinson disease (autosomal recessive, early onset) 7	246	97	3	79

Sequence references in MGI

J:69175 Taira T, et al., Molecular cloning of human and mouse DJ-1 genes and identification of Sp1-dependent activation of the human DJ-1 promoter. Gene. 2001 Jan 24;263(1-2):285-92
J:97366 Kim RH, et al., Hypersensitivity of DJ-1-deficient mice to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyrindine (MPTP) and oxidative stress. Proc Natl Acad Sci U S A. 2005 Apr 5;102(14):5215-20
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:125021 Andres-Mateos E, et al., DJ-1 gene deletion reveals that DJ-1 is an atypical peroxiredoxin-like peroxidase. Proc Natl Acad Sci U S A. 2007 Sep 11;104(37):14807-12
J:157910 Krebiehl G, et al., Reduced basal autophagy and impaired mitochondrial dynamics due to loss of Parkinson's disease-associated protein DJ-1. PLoS One. 2010;5(2):e9367
J:168618 Guzman JN, et al., Oxidant stress evoked by pacemaking in dopaminergic neurons is attenuated by DJ-1. Nature. 2010 Dec 2;468(7324):696-700
J:169897 Clements CM, et al., DJ-1, a cancer- and Parkinson's disease-associated protein, stabilizes the antioxidant transcriptional master regulator Nrf2. Proc Natl Acad Sci U S A. 2006 Oct 10;103(41):15091-6
J:169981 Waak J, et al., Regulation of astrocyte inflammatory responses by the Parkinson's disease-associated gene DJ-1. FASEB J. 2009 Aug;23(8):2478-89
J:201915 Bjorkblom B, et al., Parkinson disease protein DJ-1 binds metals and protects against metal-induced cytotoxicity. J Biol Chem. 2013 Aug 2;288(31):22809-20
J:202241 Kim KS, et al., DJ-1 Associates with lipid rafts by palmitoylation and regulates lipid rafts-dependent endocytosis in astrocytes. Hum Mol Genet. 2013 Dec 1;22(23):4805-17
J:203468 Park J, et al., SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways. Mol Cell. 2013 Jun 27;50(6):919-30
J:204791 Robert G, et al., The caspase 6 derived N-terminal fragment of DJ-1 promotes apoptosis via increased ROS production. Cell Death Differ. 2012 Nov;19(11):1769-78
J:211242 McNally RS, et al., DJ-1 enhances cell survival through the binding of Cezanne, a negative regulator of NF-kappaB. J Biol Chem. 2011 Feb 11;286(6):4098-106
J:212785 Lee JY, et al., Human DJ-1 and its homologs are novel glyoxalases. Hum Mol Genet. 2012 Jul 15;21(14):3215-25
J:239193 Liu W, et al., Park7 interacts with p47(phox) to direct NADPH oxidase-dependent ROS production and protect against sepsis. Cell Res. 2015 Jun;25(6):691-706
J:243391 Jain D, et al., Age- and diet-dependent requirement of DJ-1 for glucose homeostasis in mice with implications for human type 2 diabetes. J Mol Cell Biol. 2012 Aug;4(4):221-30
J:243468 Jain D, et al., DJ-1 Protects Pancreatic Beta Cells from Cytokine- and Streptozotocin-Mediated Cell Death. PLoS One. 2015;10(9):e0138535
J:282679 Moutaoufik MT, et al., Rewiring of the Human Mitochondrial Interactome during Neuronal Reprogramming Reveals Regulators of the Respirasome and Neurogenesis. iScience. 2019 Sep 27;19:1114-1132
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89